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Vitamic C controlled release pill and its preparation method and use

A technology for sustained-release pellets and vitamins, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, drug delivery, etc. It can solve the problems that no sustained-release preparations have been developed, and achieve improved bioavailability, good stability, and improved compliance effect

Inactive Publication Date: 2008-12-31
上海爱的发制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, although vitamin C preparations produced in China have multiple dosage forms at present, such as: injections, pills, granules, tablets and effervescent tablets, no sustained-release preparations have been developed yet.

Method used

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  • Vitamic C controlled release pill and its preparation method and use
  • Vitamic C controlled release pill and its preparation method and use
  • Vitamic C controlled release pill and its preparation method and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Embodiment 1, the preparation of sustained-release pellets (containing 510 grams of vitamin C)

[0040] 1.1 Raw materials and accessories

[0041] Microcrystalline cellulose is selected as blank core, citric acid is used as metal chelating agent, acrylic resin is used as coating auxiliary material, and talcum powder is used as lubricant.

[0042] 1.2 Preparation process

[0043] 1) Load the main drug: put the blank core (microcrystalline cellulose) in the coating pan, adjust the temperature of the coating pan to 55°C, and the speed to 40 rpm, spray a 20% acrylic resin solution containing citric acid, and gradually Spray the main ingredient vitamin C until 500 grams of the main ingredient is added;

[0044] 2) Coating: prepare 40% acrylic resin solution with ethanol, put the small particles in the coating pot, adjust the temperature of the coating pot to 55° C. and the rotating speed to 40 rpm, spray the acrylic resin solution, and gradually spray talcum powder in an a...

Embodiment 2

[0048]Embodiment two, the preparation of sustained-release pellets (containing 650 grams of vitamin C)

[0049] Corn starch particles are selected as the blank core, dimercaptoethylglycine is used as the metal chelating agent, shellac is used as the coating auxiliary material, and silicon dioxide is used as the lubricant.

[0050] Referring to the process steps described in Example 1, each component was added in sequence to prepare sustained-release pellets containing 650 grams of vitamin C. During the preparation process, the temperature of the coating pan was controlled at 70° C., and the rotation speed was 60 rpm.

[0051] The prepared slow-release pellets per kilogram approximately contain: 650 grams of vitamin C, 150 grams of blank core (corn starch), 10 grams of dimercaptoethylglycine, 110 grams of shellac, 80 grams of talcum powder, and an appropriate amount of 95% ethanol .

Embodiment 3

[0052] Embodiment three, the preparation of sustained-release pellets (containing 800 grams of vitamin C)

[0053] Sucrose particles were selected as the blank core, tartaric acid was used as the metal chelating agent, povidone was used as the coating auxiliary material, and silicon dioxide was used as the lubricant.

[0054] Referring to the process steps described in Example 1, each component was added in sequence to prepare sustained-release pellets containing 800 grams of vitamin C. During the preparation process, the temperature of the coating pan was controlled at 89° C., and the rotation speed was 35 rpm.

[0055] The prepared slow-release pellets per kilogram approximately contain: 800 grams of vitamin C, 80 grams of blank core (sucrose particles), 5 grams of tartaric acid, 70 grams of povidone, 45 grams of silicon dioxide, and an appropriate amount of 95% ethanol.

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PUM

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Abstract

A slow-releasing VC micropill contains VC 500-950g, core material 0-200g, metallic chelating agent 0.3-18g, coating 20-180 g and lubricant. Its advantage is long releasing period.

Description

technical field [0001] The present invention relates to a vitamin C preparation, in particular to a vitamin C slow-release pellet and its preparation method and application. Background technique [0002] Vitamin C was separated and crystallized from lemon juice concentrate in 1932, artificially synthesized in 1933, and applied clinically. Vitamin C is widely used in various clinical departments, mainly for the prevention and treatment of scurvy, and can also be used as an adjuvant treatment for various acute and chronic infectious diseases and purpura. [0003] At present, with the increase of my country's per capita income, more meat products are consumed, people's awareness of health care is enhanced, and the demand for vitamin products is increasing day by day. The consumption of vitamin C products is also increasing, and the market capacity is greatly increased. my country is a big producer of vitamin C raw materials, the price is relatively low, the quality has reached...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/375A61K9/22A61P3/02
Inventor 韦友华徐富坤杨卫红胡愈璋陆静
Owner 上海爱的发制药有限公司
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