Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Amoxicillin antibacterial agent containing nano silver, and its preparing method

A technology of amoxicillin and amoxicillin capsules, which is applied in the field of amoxicillin antibacterial agents and its preparation, can solve the problems of increased drug side effects and failure to significantly improve the efficacy of antibacterial agents, etc., so that raw materials are easily available and beneficial Industrialization and commercialization, the effect of simple production process

Inactive Publication Date: 2009-06-24
TONGJI UNIV
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These methods solve the problem of drug resistance to a certain extent, but fail to significantly improve the efficacy of antibacterial agents, especially with the entry of some organic components, the side effects of drugs on the human body also increase

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Amoxicillin antibacterial agent containing nano silver, and its preparing method
  • Amoxicillin antibacterial agent containing nano silver, and its preparing method
  • Amoxicillin antibacterial agent containing nano silver, and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] (1) Preparation of nano silver

[0025] At normal temperature and pressure, to a concentration of 0.01mol / L AgNO 3 The solution is injected with ammonia gas to maintain the pH of the solution=12, and then [Ag(NH 3 ) 2 ]+ solution and 5% (wt%) sodium dodecyl sulfate (SDS) aqueous solution are mixed in equal volumes into a conical flask and placed on a magnetic stirrer at a temperature of 70°C. Add vitamin C (concentration: 0.01mol / L) drop by drop with a medical infusion set, while keeping the rotating speed of the stirring bar at 120 rpm, and react for 2 hours. Use alcohol as a solvent to centrifuge and wash the precipitate (repeat several times to remove the surfactant), and then vacuum dry to obtain nano silver.

[0026] (2) Nano silver and amoxicillin antibacterial performance test (minimum inhibitory concentration test)

[0027] In the antibacterial test, the test strain (Escherichia coli F220) was activated in LB medium at 37° C., and then cultivated until the a...

Embodiment 2

[0034] Under the same conditions, add 1ml of mixed solutions of different concentrations of nano-silver and amoxicillin, 0.15mg / ml amoxicillin+10μg / ml nano-silver, to an equal amount of bacterial strains, and stir for 10 minutes to obtain the product. Figure 4 It can be seen that the synergistic antibacterial effect of amoxicillin and nano-silver is far better than that of amoxicillin and nano-silver alone.

Embodiment 3

[0036] Utilize commercially available nano-silver (particle diameter is 30-40nm) to be formulated into the silver colloid dispersion liquid of 10 μ g / ml and the powder (specification 0.125g / grain) in the commercially available amoxicillin capsule is formulated into the solution mixing of 0.25mg / ml, The mass ratio of nano-silver and amoxicillin is 1:10, and the product is obtained by stirring for 8 minutes, and the implementation of joint antibacterial has also achieved satisfactory results.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
concentrationaaaaaaaaaa
Login to View More

Abstract

The invention belongs to the technical field of biomedicine, and in particular relates to an amoxicillin antibacterial agent containing nano-silver and a preparation method thereof. At normal temperature, mix the amoxicillin solution and the silver colloid dispersion of nano-silver in proportion, and stir for 8-20 minutes to obtain the desired product; the obtained antibacterial agent is used as the experimental object for antibacterial research on Escherichia coli. The results show that the combination of nano-silver and amoxicillin exhibits a more prominent synergistic antibacterial effect, and its antibacterial effect far exceeds the sum of the antibacterial effects when the two are used alone at the same dose. The raw materials used in the invention are easy to obtain, the cost is low, the operation and equipment are simple and convenient, and the compound antibacterial agent can be prepared relatively conveniently, which is beneficial to industrialization and commercialization.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to an amoxicillin antibacterial agent containing nano-silver and a preparation method thereof. Background technique [0002] β-lactams (β-lactam) and sulfonamides are relatively broad-spectrum antibiotics. Due to repeated application for a long time, a large number of bacteria have strong resistance to such antibacterial agents. Therefore, in daily life and medical treatment, increasing the dose of antibacterial agents is usually used to achieve a satisfactory antibacterial effect. The consequence of doing this can only be to continuously increase the drug resistance of bacteria, and the drug resistance of bacteria has increasingly become a serious problem affecting human health and life. In recent years, people have studied the mechanism of bacterial drug resistance, and found that the resistance of bacteria to β-lactams is related to the amount of β-lactam hydrola...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/38A61K9/08A61K9/14A61K9/12A61K9/20A61P31/04A61K31/43
Inventor 吴庆生马杰李平吴昌柱孙冬梅丁亚平
Owner TONGJI UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products