Integrase inhibiting peptide and its application in preparing AIDS-treating medicine

A technology for inhibiting peptides and integrases, applied in the direction of peptides, antiviral agents, etc., can solve problems such as peripheral nerve diseases and neutropenia
CN100543034CInactive Publication Date: 2009-09-23ZHEJIANG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ZHEJIANG UNIV
Publication Date
2009-09-23
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides an integrase inhibitory peptide, which is one of seven polypeptide organic compounds selected from a, b, c, d, e, f, and g, soluble in water, and connected by peptide bonds between amino acids, capable of inhibiting HIV-1 integrase activity, the molecular weights are: 974.3, 770.8, 822.9, 830.9, 849.0, 789.8, 788.8. The polypeptide organic compound of the invention can inhibit the activity of HIV-1 integrase, interrupt the proliferation of virus DNA in host cells and its life cycle, and can be used in the preparation of drugs for treating AIDS. At the same time, it can also be used for further research on the structure, mechanism of action of integrase and AIDS treatment drugs.
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Description

technical field

[0001] The invention belongs to organic compounds, and mainly relates to polypeptide organic compounds, especially artificially synthesized polypeptide organic compounds and their application in the preparation of drugs for treating AIDS. technical background

[0002] The process of viral DNA integration into host cell chromosomal DNA is an extremely important link in the life cycle of retroviruses, and integrase (IN) plays a key role in this link. In the past, the classic AIDS (AIDS) treatment drugs included: nucleoside reverse transcriptase inhibitors, non-nucleoside reverse transcriptase inhibitors and protease inhibitors; Drug resistance, and long-term use of these three types of drugs will also cause side effects such as anemia, neutropenia, myopathy, and peripheral nerve disease. Therefore, in order to overcome the existing problems in the treatment of AIDS, people began to search for drugs that act on new target molecules, and drugs that inhibit the i...

Claims

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