Acetaminopher DC90 fine particle and preparation method thereof

A technology of acetaminophen and fine particles, which is applied in the direction of pharmaceutical formulations, medical preparations of non-active ingredients, drug combinations, etc., can solve the problems of uneven content of active ingredients, difficulty in mixing uniformly, and large accumulation ratio, and achieve flow Good resistance, good compressibility, and small bulk specific gravity
CN100569227CActive Publication Date: 2009-12-16ANQIU LUAN PHARMA
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Patents(China)
Current Assignee / Owner
ANQIU LUAN PHARMA
Publication Date
2009-12-16

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Abstract

The invention discloses paracetanol DC90 fine particles and a preparation method thereof. The paracetanol DC90 comprises following materials by weight ratio: 90 percent of paracetanol, 3.50 percent of cornstarch, 3.50 percent of pre gelatinized starch, 2.00 percent of povidone, 0.5 percent of crospovidone and 0.5 percent of stearic acid. Firstly, the paracetanol and the cornstarch are mixed evenly, then the pre gelatinized starch and the povidone are made into starch slurry to be used as bond which is evenly sprayed on the mixture of the fluidied paracetanol and cornstarch, fluidized bed granulation is carried out in the inlet air temperature, the wet particles are dried under the temperature of 80 DEG C and then are cooled at the temperature of 50 DEG C till water conforms to the requirement, the sizes of the particles are adjusted, the stearic acid and the crospovidone are added after the particle sizes are adjusted to be mixed evenly to obtain the paracetanol DC90 fine particles. The invention adopts the above technical proposal to inspect the product, and the particles are fine and uniform and have favorable fluidity, thereby being well and evenly mixed with other small quantities of active components powder.
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Description

technical field

[0001] The present invention relates to the formulation and preparation method of acetaminophen DC90 fine particles Background technique

[0002] Paracetamol DC90 granule, its main active ingredient is 90% paracetamol, 10% is other additives.

[0003] The main function of this product is antipyretic and analgesic. It acts on the body temperature center and is used for headache, fever, joint pain, neuralgia and dysmenorrhea.

[0004] This product can be directly filled into capsules or directly compressed into tablets. However, with the demand of the current international market, some customers want to add other active ingredients to the granule to make a compound preparation to increase its curative effect. However, since the original DC90 granules have a large particle size and a relatively large bulk specific gravity, it is not easy to mix evenly when adding a small amount of active ingredient powder, resulting in uneven content of the active ingredient i...

Claims

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