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Medicinal compositions

A composition, the technology of geniposide, applied in the field of medicine or health care product combination, can solve the problem of no scientific basis, no suggestion or attempt, etc.

Active Publication Date: 2009-12-23
YUNNAN BIOVALLEY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far, the existing technology has not provided scientific basis for whether scutellaria breviscapus and gardenia can be used in combination, and whether the mechanism of action of the two is additive, synergistic or antagonistic.
As for whether the two can be used in combination for other diseases (such as cardiovascular and cerebrovascular diseases), the prior art does not even have similar hints or attempts

Method used

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  • Medicinal compositions
  • Medicinal compositions
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0129] Embodiment 1 capsule

[0130] Take 10g of Erigeron breviscapus, crush it into a coarse powder, add 75% ethanol to reflux and extract three times, the first and second times each for 2 hours, and the third time for 1 hour, combine the extracts, concentrate under reduced pressure to about 400ml, and extract three times with n-butanol , 300ml each time, combine the n-butanol extract, concentrate under reduced pressure until there is no n-butanol smell, add 200ml of water, heat to dissolve, then dilute sodium hydroxide to adjust the pH value to 7, filter, and the filtrate is spray-dried to obtain the extract I standby;

[0131] Take 5g of gardenia, crush it into a coarse powder, add 75% ethanol to reflux and extract three times, the first and second times each for 2 hours, and the third time for 1 hour, combine the extracts, concentrate under reduced pressure to about 400ml, and extract three times with n-butanol , 300ml each time, combine n-butanol extracts, concentrate u...

Embodiment 2

[0133] Example 2 tablet

[0134] Take one part of the extract I and two parts of the extract II of Example 1, add low-substituted hydroxypropyl cellulose, magnesium stearate, starch, and microcrystalline cellulose, and prepare 1000 grains according to the standard granulation and tableting process. After testing, it contains scutellarin 50mg / tablet, caffeoylquinic acid 200mg, and geniposide 100mg / tablet.

Embodiment 3

[0135] Embodiment 3 soft capsules

[0136] Get two parts of extract I and one part of extract II of Example 1, add starch and magnesium stearate, mix well, and make soft capsules according to the standard process. After testing, each capsule contains 100mg of scutellarin, 500mg of caffeoylquinic acid and 50mg of geniposide.

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Abstract

The invention relates to a compound for medicine or health care products and the preparation and application. The compound contains natural plant extractives or the monomers in the compound are active ingredientss. The medicine compound of the invention can be applied for treating and preventing cardio-cerebrovascular disease, diabetes and the complication of the diabetes, senile dementia and hyperlipoidemia.

Description

technical field [0001] The present invention relates to a combination of medicines or health care products, in particular, a composition for medicinal or functional health care products containing natural plant extracts or monomers, used for the treatment and / or prevention of diabetes and its complications, old age Dementia, cardiovascular and cerebrovascular diseases, hyperlipidemia, and for the prevention of recurrence of cardiovascular and cerebrovascular diseases. Background technique [0002] Diabetes is one of the four deadly diseases threatening human health. According to statistics, there are currently 130 million type II diabetes patients in the world, and 30 million in my country. There is currently no cure. The incidence of diabetes is getting higher and higher, and the age is getting younger. The quality of life of diabetic patients is seriously affected, which causes a significant economic and mental burden to society and families. Therefore, it is urgent to d...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/744A61K31/7048A61P3/06A61P3/10A61P9/10A61P25/28
Inventor 林艳和潘锡平
Owner YUNNAN BIOVALLEY PHARMA CO LTD