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Method and system for detecting spin valve magnetic marked immunity biosensor array, and system

A biosensor and detection system technology, applied in the field of bioimmune detection, can solve the problems of not revealing the sensitivity of the insulating material biosensor, the sensitivity is not high, and there is no revealing, so as to achieve the effect of improving the sensitivity, improving the detection efficiency and improving the detection accuracy

Inactive Publication Date: 2007-07-25
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0022] U.S. Patent 5,981,297 discloses a biosensor using magnetic detection labels, but this patent technology has the following disadvantages: first, the patent does not use a spin valve, so the sensitivity is not high; second, because the patent does not disclose how to pass Improving the thickness and activity of the insulating material between the magnetoresistive element and the binding molecules to improve the sensitivity of the biosensor; moreover, the patent does not disclose how to improve the detection accuracy by improving the solenoid structure in the detection system; In addition, the patent does not disclose how to solve the error caused by the temperature drift of the GMR spin valve chip through the balanced bridge circuit

Method used

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  • Method and system for detecting spin valve magnetic marked immunity biosensor array, and system
  • Method and system for detecting spin valve magnetic marked immunity biosensor array, and system
  • Method and system for detecting spin valve magnetic marked immunity biosensor array, and system

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Embodiment 1

[0065] The present invention provides a GMR spin valve magnetic label immune biosensor array detection method for judging whether eight target antigens (such as virus molecules) are contained in a sample to be tested (such as a blood sample), the method comprising:

[0066]Connect eight initial GMR spin valve chips to a detection module, and measure the magnetically sensitive areas of these eight initial GMR spin valve chips. In the prior art, a chip array is integrated on the detection module. In this embodiment, the initial GMR spin valve chip adopts the spin valve developed by Shenzhen Huaxia Magnetic Electronics Technology Development Co., Ltd. disclosed in Chinese Patent Application No. 02147695.0. Its structure is shown in Figure 3, which includes pinned layer 1 , pinned layer 2 , nonmagnetic spacer layer 3 and free layer 4 . In the free layer of the spin valve structure, a low coercive force ferromagnetic material NiFeMoMn is used, thereby obtaining a spin valve giant ...

Embodiment 2

[0076] This embodiment is similar to Embodiment 1, the difference is:

[0077] The active protective film is a polytetrafluoroethylene film prepared by radio frequency magnetron sputtering deposition method, wherein the sputtering pressure is 8Pa, the radio frequency voltage is 700V, the radio frequency current is 170mA, the self bias voltage is 200V, and the sputtering time is 30 minutes.

[0078] At this time, the sputtering power of the plasma magnetic filtration chemical vapor deposition is 8W, the excitation current is 6A, the sputtering pressure is 20Pa, the substrate bias is 0V, and the modification time is 15min.

Embodiment 3

[0080] This embodiment is similar to Embodiment 1, the difference is:

[0081] The active protective film is a diamond-like carbon film prepared by plasma magnetic filtration chemical vapor deposition, wherein the sputtering power is 8W, the excitation current is 5A, the sputtering pressure is 20Pa, the substrate bias is -20V, and the deposition time is 2 hours.

[0082] At this time, the sputtering power of the plasma magnetic filtration chemical vapor deposition used to form ammonia functional groups was 8W, the excitation current was 5A, the sputtering pressure was 20Pa, the substrate bias was 10V, and the modification time was 15min.

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Abstract

A labeled immune biological transducer array system of GMR spin valve comprises solenoid to contain detection module, magnetic field driving circuit connected to solenoid and used to generate constant magnetic field in solenoid, data processing circuit connected to detection module and used to obtain and analyze resistance value variation of GMR spin valve chip, a pair of balance bridge circuit used to detect temperature drift of GMR spin valve chip and to carry out compensation. Its detecting method is also disclosed.

Description

technical field [0001] The invention relates to a biological immune detection method and system, in particular to a biological immune detection method and system using a GMR (giant magnetoresistance) spin valve. Background technique [0002] The 21st century is the era of biotechnology, and biosensors are a very active and promising research field in the interdisciplinary areas of life sciences and information sciences. Its research focus is mainly on the wide application of various bioactive materials. Combined with sensors to develop transducers with recognition functions and become an original technology for manufacturing new analytical instruments and analytical methods. Now, biosensors have been widely used in industrial control, medical diagnosis, environmental detection, food and drug analysis, etc. [0003] Since the target to be detected and the biorecognition components immobilized on the surface of the transducer mostly carry out the recognition reaction in the s...

Claims

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Application Information

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IPC IPC(8): G01N33/543G01N35/00C12Q1/00
Inventor 何振辉陈弟虎库万军李澧杨芝茵黄熙黄建军
Owner SUN YAT SEN UNIV
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