Loratadine oral compound medication composition

A technology of loratadine and desloratadine, which is applied to the pharmaceutical composition for oral administration, and the sustained-release part of the central antitussive drug, can solve the problem of insufficient pharmacokinetic characteristics of treatment and can not meet the needs of patients with frequent coughs. And other issues

Inactive Publication Date: 2007-08-15
CHONGQING PHARMA RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

That is to say, a compound similar to Pedicof-D can play a synergistic role in the treatment of cough in terms of mechanism of action. However, the significant difference in pharmacokinetic characteristics also brings about a lack of treatment, that is, it cannot meet the needs of patients with frequent cough. needs
[0006] Loratadine and dextromethorphan have been marketed at home and abroad as unilateral common preparation products with comprehensive dosage forms, but the compound of the two is only listed in India’s Ordain Health Care company Pedicof-D syrup

Method used

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  • Loratadine oral compound medication composition
  • Loratadine oral compound medication composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Component Weight (g)

[0044]

[0045] Dextromethorphan Hydrobromide 30

[0046] Microcrystalline Cellulose 162

[0047] Stearic acid 60

[0048] Slow-release granules

[0049] Ethyl cellulose 60

[0050] Povidone 14.4

[0051] Magnesium stearate 3.6

[0052]

[0053] Loratadine 10

[0054] Lactose 83.8

[0055] Starch 35

[0056] immediate release granules

[0057] Sodium carboxymethyl starch 9.1

[0058] Magnesium stearate 1.4

[0059] ...

Embodiment 2

[0067] Component Weight (g)

[0068]

[0069] Extended Release Pellets Dextromethorphan Hydrobromide 30

[0070] Sucrose 136

[0071] Stearyl Alcohol 45

[0072] Sodium Alginate 30

[0073] starch 4

[0074] Talc 5

[0075]

[0076] Desloratadine 5

[0077] Sucrose 85.5

[0078] Immediate Release Pellets Low Substituted Hydroxypropyl Cellulose 6

[0079] Crospovidone 2

[0080] Talc 1.5

[0081]

[008...

Embodiment 3

[0088] Component Weight (g)

[0089]

[0090] Dextromethorphan Hydrobromide 30

[0091] Calcium hydrogen phosphate 262

[0092] Extended release tablet core Hypromellose 35

[0093] Sodium Carboxymethyl Cellulose 15

[0094] Wheat Starch 28

[0095]

[0096] Isolation coating Isolation coating liquid Appropriate amount

[0097]

[0098] Loratadine 10

[0099] Simethicone 1

[0100] Immediate Release Coating Polyethylene Glycol 4

[0101] Acrylic 10

[0102] ...

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PUM

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Abstract

This invention relates to an orally adminstered compound Chinese medicinal composition of loratadine for treating cough. The composition comprises quick-release part containing loratadine and slow-release part containing centrum antitussive drug, wherein the centrum antitussive drug is preferably dextromethorphan. The invention maintains the quick and long lasting action of loratadine or desloratadine, overcomes the quick releasing and short action on relieving cough of dextromethorphan, slow releases dextromethorphan, and maintains the drug effect to arrive the purpose of relieving cough for a long time.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a pharmaceutical composition for oral administration for treating cough, which contains an effective amount of loratadine or desloratadine immediate-release part, and an effective amount of central antitussive Sustained release part, and pharmaceutical excipients. The composition is administered once a day to treat cough and has a long-term effect. Background technique [0002] Cough is a common symptom of respiratory disease. In recent years, due to the increasingly serious air pollution on the earth, the deterioration of the living environment of human beings, the destruction of the human body's immune function, the incidence of respiratory diseases has been increasing year by year, as evidenced by the prevalence of atypical pneumonia. Statistics show that in the United States, cough is the second largest number of respiratory outpatient visits. Accordi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/485A61P11/14A61K31/4545
Inventor 牟才华杨立华张涛
Owner CHONGQING PHARMA RES INST
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