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Xanthin micro-capsule and the preparing method

A technology of lutein and cellulose, applied in the field of microcapsule preparation, can solve the problems of instability of lutein, limited application, easy to be oxidized and decomposed, etc., and achieve the effects of eliminating environmental pollution and increasing fluidity

Active Publication Date: 2011-11-09
浙江一新制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, free lutein is very unstable, easy to be oxidized and decomposed, very sensitive to light and oxygen, insoluble in water, and cannot be suspended in water, which greatly limits its application in food, medicine, and feed industries

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Mix 50g of lutein (content: 70% ± 5%) and 25g of microporous starch at room temperature, add 35g of maltodextrin, 6g of CMC-Na (carboxymethyl cellulose), 5g of sucrose, tert-butyl Mix 0.1g of phenol and 15g of silk fibroin colloid in aqueous solution, stir evenly, grind evenly with a colloid mill, spray dry the colloid at an inlet air temperature of 150°C, and control the outlet air temperature at 80°C to 90°C. Microcapsules with an average particle size of 150 μm and a lutein content of 22% were obtained.

Embodiment 2

[0017] Mix 50g of lutein (content: 70%±5%) and 20g of cross-linked microporous starch at room temperature, add 40g of cyclodextrin, 3g of hydroxyethyl cellulose, 5g of lactose, 0.1g of vitamin C, and gum arabic Mix the aqueous solution of 20g colloid, stir evenly, and use a high-pressure homogenizer to homogenize evenly. The colloid is spray-dried at the inlet air temperature of 150°C, and the outlet air temperature is controlled at 80°C to 90°C. Microcapsules with an average particle size of 121 μm and a lutein content of 21% were obtained.

Embodiment 3

[0019] Mix 50g of lutein (70%±5%) with 25g of microporous starch at room temperature, add 40g of maltodextrin, 6g of hydroxypropyl methylcellulose, 5g of glucose, 0.1g of vitamin E, and xanthan gum Mix the aqueous solution of 15g colloid, stir evenly, grind evenly with a colloid mill, spray dry the colloid at the inlet air temperature of 150°C, and control the outlet air temperature at 80°C to 90°C. Microcapsules with an average particle size of 132 μm and a lutein content of 21% were obtained.

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Abstract

The present invention relates to lutein microcapsule and its spray drying preparation process. The lutein microcapsule has core material with the main components including lutein, and microporous starch or cross-linked starch; and covering material of cellulose, sugar, plant glue or protein, dextrin and antioxidant. The lutein microcapsule has size of 3-300 microns. The preparation process of the lutein microcapsule includes the following steps: mixing lutein with starch at normal temperature, mixing with water solution of cellulose, sugar and plant glue or protein, grinding or homogenizing the mixture liquid to form homogeneous colloid, and spray drying the colloid. The preparation process uses no organic solvent, and the prepared lutein microcapsule has high safety, high stability and high flowability, and is suitable for tabletting and encapsulating.

Description

technical field [0001] The invention relates to a microcapsule preparation process, in particular to a lutein microcapsule prepared by a spray drying method and a preparation method thereof. Background technique [0002] Lutein is widely distributed in nature and is especially present in marigolds, corn, lettuce, egg yolk. Lutein used in the food industry, feed industry, and pharmaceutical industry is generally extracted from marigolds. The animal feed and food industries as well as the pharmaceutical industry have shown great interest in lutein. The poultry industry benefits from the addition of lutein to increase egg yolk. Scientific studies have reported that lutein is related to reducing the risk of age-related macular degeneration (AMD) caused by oxidative damage to the macular area of ​​the retina, and lutein can effectively prevent arteriosclerosis, cataracts, and inhibit the occurrence of cancer. In addition, lutein can also be used as a food coloring agent. A la...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J13/04A61K9/50A61K31/07A61P27/02A61P27/12A23L1/27A23L5/40
Inventor 郑亚津林军
Owner 浙江一新制药股份有限公司
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