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Colchicine sustained-release pellets and the preparing method

A technology of colchicine and sustained-release pellets, applied in the field of medicine, can solve the problems of easy occurrence of gastrointestinal reactions, poor patient compliance, etc., and achieve the effects of small differences in individual bioavailability, fewer doses, and less breakage

Inactive Publication Date: 2007-09-26
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In this way, multiple frequent administrations are required every day, and gastrointestinal reactions are prone to occur, and the patient's compliance is poor.

Method used

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  • Colchicine sustained-release pellets and the preparing method
  • Colchicine sustained-release pellets and the preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1 The preparation method of the colchicine sustained-release preparation using Eudragit NE30D aqueous dispersion as the pellet coating material: first take 0.2 g of colchicine, 90 g of microcrystalline cellulose, and 10 g of lactose, and pass the drug and auxiliary materials through 100 mesh Sieve, mix evenly, add an appropriate amount of 2% hypromellose, make the drug and auxiliary materials into a soft material, then move the soft material into an extrusion machine and extrude it into a high-density strip, and finally in a centrifugal spherical shape In the chemical machinery, the strips are crushed into granules and rounded to make pellets. Coat the pellets with Eudragit NE30D aqueous dispersion (after the weight of the coating increases by 1% to 30% based on the amount of polymer), control the amount of coating solution according to the drug release rate, and finally pack into bags or capsules.

Embodiment 2

[0033] Example 2 The preparation method of colchicine sustained-release preparation using Eudragit RS 30D aqueous dispersion as pellet coating material: firstly, take 0.4 g of colchicine, 90 g of microcrystalline cellulose, 90 g of lactose, and 20 g of starch. Pass the medicine and auxiliary materials through a 100-mesh sieve, mix evenly, and use 2% hypromellose solution as a binder in a centrifugal coating granulator to make pellets. The pellets are coated with Eudragit RS 30D aqueous dispersion (after the weight of the coating is increased by 1% to 30% based on the amount of polymer), and the amount of coating solution is controlled according to the drug release rate, and packed into bags or capsules.

Embodiment 3

[0034] Example 3 The preparation method of colchicine sustained-release preparation using ethyl cellulose aqueous dispersion as pellet coating material: first take 1 g of colchicine, 100 g of microcrystalline cellulose, 100 g of lactose, and 10 g of starch. Pass the drug and auxiliary materials through a 100-mesh sieve, mix them evenly, and use water as a binder in a centrifugal coating granulator to make pellets. The pellets are coated with ethyl cellulose aqueous dispersion (after the weight of the coating is increased by 1% to 30% based on the amount of polymer), and packed into bags or capsules.

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Abstract

The invention relates to a colchicines slow release micro drop and relative preparation, belonging to medical technique, comprising that mixing drug and findings uniformly, adding some adhesive, to prepare drug drop coated with slow release clothing sheet to control the drug to release slowly. Via adjusting the formula of clothing sheet, the drug slow release speed can be adjusted effectively. And the prepared micro drop can be packed into bag, or capsule into capsule agent, to be orally fed. User only needs to take 1-2 times of inventive drug in each day, while the invention can avoid peak-valley condition, stabilize drug density in blood, reduce taken time, and improve compliance, compared with general agent.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a colchicine sustained-release pellet and a preparation method thereof. Background technique [0002] Colchicine included in the Chinese Pharmacopoeia is an alkaloid extracted from the bulb of Iphigenia indica Kunth et Benth. [0003] Gout is a disease of purine metabolism disorder in the body. Due to excessive uric acid in the blood, uric acid is deposited in the joints, connective tissue and kidneys, causing granulocyte infiltration, causing local inflammation and pain. Colchicine inhibits the infiltration and phagocytosis of granulocytes during gout attacks, and has a selective anti-inflammatory effect on acute gouty arthritis. The symptoms of joint redness, swelling, heat, and pain subside within a few hours after use. At present, colchicine is still the most effective drug for the treatment of acute attacks of gout, and it can be effective quickly after taking the drug. C...

Claims

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Application Information

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IPC IPC(8): A61K31/165A61K9/16A61P19/06A61P19/02
Inventor 王思玲邱敦有苏德森姜同英
Owner SHENYANG PHARMA UNIVERSITY
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