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Biphase emulsification adjuvant and the technique for preparing the same

An adjuvant and stabilizer technology, applied in the field of two-phase emulsified adjuvant and its manufacturing process, can solve problems such as research and development work gaps, and achieve the effects of constant quality, easy injection, and low viscosity

Inactive Publication Date: 2007-09-26
YIXING ZHONGMU BIOLOGICAL ADJUVANT TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

With the development of vaccines, the types and quality of adjuvants have also been continuously increased and improved, but there is still a gap between the research and development of domestic adjuvants and foreign countries

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Two-phase emulsified adjuvant-A5 and its preparation, first carry out ingredients according to the following ratio

[0027] Injection Grade White Oil 85%

[0028] Span - 80 5%

[0029] Tween-80 4%

[0030] 1.2-Propanediol 3%

[0031] 1% PVP 3%

[0032] Under room temperature conditions, first emulsify veterinary white oil for injection in an emulsification tank to obtain light liquid paraffin oil; Minutes until clarification, then add hydrophilic Tween-80 under stirring state and stir for 5 minutes, stir and mix evenly, then add 1.2 propylene glycol, after stirring evenly, finally add polyvinylpyrrolidone until clarification, and let it stand for 30 minutes. Sampling inspection during finished product filling.

Embodiment 2

[0034] Two-phase emulsified adjuvant-A5 and its preparation, first carry out ingredients according to the following ratio

[0035] Veterinary Injection Grade White Oil 80%

[0036] Span-80 8%

[0037] Tween-80 6%

[0038] 1.2-Propanediol 3%

[0039] 1% PVP 3%

[0040] Under room temperature conditions, first emulsify veterinary white oil for injection in an emulsification tank to obtain light liquid paraffin oil; -7 minutes until clarification, then add hydrophilic Tween-80 under stirring state and stir for 3-7 minutes, stir and mix evenly, then add 1.2 propylene glycol, after stirring evenly, finally add polyvinylpyrrolidone until clarification, and let it stand for 25 -35 minutes, sample inspection when filling the finished product.

Embodiment 3

[0042] Two-phase emulsified adjuvant-A5 and its preparation, first carry out ingredients according to the following ratio

[0043] Veterinary Injection Grade White Oil 82.5%

[0044] Span-80 7.5%

[0045] Tween-80 5.5%

[0046] 1.2-Propanediol 2.5%

[0047] 1% PVP 2%

[0048] Under room temperature conditions, first emulsify veterinary white oil for injection in an emulsification tank to obtain light liquid paraffin oil; -7 minutes until clarification, then add hydrophilic Tween-80 under stirring state and stir for 3-7 minutes, stir and mix evenly, then add 1.2 propylene glycol, after stirring evenly, finally add polyvinylpyrrolidone until clarification, and let it stand for 25 -35 minutes will do. Sampling inspection during finished product filling.

[0049] The present invention and foreign products of the same category carry out comparative experiment repeatedly, and its result is as follows:

[0050] 1. Storage temperature:

[0051] Two-phase emulsified adjuvant-A5...

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PUM

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Abstract

The invention relates to a bidirectional oil emulsion agent used in immunity agent, which comprises animal injection white oil, Siban 80, tuwen 80, stabilizer 1.2 propanediol, activator PVP polyvinyl pyrrolidon. And the production comprises that in room temperature, first emulsifying animal injection white oil in an emulsifying pot, to obtain light liquid wax oil, to be added with the lipophilic SIban-80, to be mixed for 3-7min at 75-80r / min speed until foam disappears and transparent, then mixing and adding hydrophilic tuwen-80 to be mixed for 3-7min uniformly, adding 1.2 propanediol, mixing uniformly, adding polyvinyl pyrrolidon until foam disappears and transparent, laying for 25-35min. The invention has low viscidity, injection support, uniform size, and adsorption support, with high stability, long service life, and the color in white or milky white with some pink.

Description

[0001] Involved areas [0002] The invention relates to a two-phase oil emulsion adjuvant used in immune preparations, in particular to a two-phase emulsified adjuvant and its manufacturing process. Background technique [0003] Adjuvants can enhance the immunogenicity of antigens and improve the specific immune effect of antigens. As early as 1925, adjuvants have been used in immunization preparations. In addition, according to the article "Adjuvant and Its Application in Gene Immunity Research" by Guo Huichen et al., oil adjuvant can stimulate local granuloma and inflammation in animals, and attract macrophages to gather, and these cells produce a large number of active mediators: activity The medium further enhances the cellular and humoral immune responses. Immunological reminder: Immunoreactivity may depend on the concentration and duration of signals reaching lymph nodes or signals induced on APCS (antigen presenting cells). The oil emulsion can prolong the delivery t...

Claims

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Application Information

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IPC IPC(8): A61K47/44A61K9/107A61K39/39A61K47/06A61K47/10A61K47/22A61K47/26A61K47/32
Inventor 尹锡明潘春刚
Owner YIXING ZHONGMU BIOLOGICAL ADJUVANT TECH
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