Pharmaceutical composition of containing puerarin and leaves of hawthorn
A composition and technology of hawthorn leaves are applied in the field of medicine to achieve the effects of reducing cardiac preload, stabilizing various indicators, and uniform and stable drug quality
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Embodiment 1
[0131] The preparation of embodiment 1 hawthorn leaf total flavonoids
[0132] Take hawthorn leaves, dry and crush them, add 60% ethanol to reflux and extract three times, each time for 1 hour, add 8 times the amount of ethanol, combine the extracts, filter, and recover the ethanol from the filtrate under reduced pressure until the relative density is 1.04-1.06 (60°C) After diluting with an equal amount of water, shake and extract with 1 / 2 times the amount of petroleum ether (60-90°C), discard the petroleum ether solution, shake and extract the aqueous layer with ethyl acetate, and depressurize the extract Recover ethyl acetate and concentrate to dryness, then add appropriate amount of water to dissolve, add to the treated polyamide column (30-60 mesh, wet packing with ethanol, pre-wash with appropriate amount of ethanol, then wash with water until no alcohol smell, set aside ), first eluted with 2 times column volume of water, discarded the water washing solution, and then el...
Embodiment 2
[0147] Embodiment 2: Preparation of GS composition powder injection
[0148] prescription:
[0149] Hawthorn leaves total flavonoids 47.6g (equivalent to about 2000g hawthorn leaves)
[0150] Puerarin 200g
[0151] Polysorbate 80 80g
[0152] Mannitol 300g
[0153] Sorbitol 50g
[0154] Add sterile water for injection to 3000ml
[0155] A total of 1000 sticks were prepared
[0156] Preparation Process:
[0157] (1) Firstly, the containers used for liquid preparation, antibiotic glass bottles, rubber stoppers, etc. are aseptically treated.
[0158] (2) Weigh the raw and auxiliary materials according to the prescription quantity.
[0159] (3) Add the total flavonoids of hawthorn leaves into 30% sterile water for injection and heat to dissolve completely. Add mannitol and sorbitol to 30% sterile water for injection, heat and stir to dissolve completely, add polysorbate 80 to 20% sterile water for injection to make an aqueous solution, add puerarin to heat and dissolve, c...
Embodiment 3
[0167] Embodiment 3: Preparation of GS composition aqueous injection
[0168] prescription:
[0169] Hawthorn leaves total flavonoids 47.6g (equivalent to about 2000g hawthorn leaves)
[0170] Puerarin 200g
[0171] Macrogol 400 200ml
[0172] Ethanol 200ml
[0173] Add water for injection to 2000ml
[0174] A total of 1000 sticks were prepared
[0175] Preparation Process:
[0176] (1) Dispose of the pipes and containers used for liquid preparation one day in advance, and rinse them with fresh water for injection before use.
[0177] (2) Mix ethanol with an equal amount of water, add total flavonoids of hawthorn leaves to dissolve; dissolve polyethylene glycol 400 with 50% water, and then add puerarin and stir to dissolve.
[0178] (3) Combine the above two solutions, and add water for injection to the full amount.
[0179] (4) Add activated carbon for needles with a dosing volume of 0.1%, heat and stir for 15 minutes.
[0180] (5) Decarburization by sand filter rod ...
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