Hollow micro-ball containing phosphazene and preparing method

A hollow microsphere and phosphazene technology, which is applied in the field of polymer microspheres and their preparation, can solve the problems of complicated preparation method of hollow microspheres and limited research, and is easy to realize and good biologically possible to meet the requirements of experimental equipment and experimental conditions. The effect of degradability and good biocompatibility

Inactive Publication Date: 2007-11-14
SHANGHAI JIAO TONG UNIV
View PDF0 Cites 16 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation methods of biocompatible and biodegradable hollow microspheres reported so far are relatively complicated, which limits their further research.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Hollow micro-ball containing phosphazene and preparing method
  • Hollow micro-ball containing phosphazene and preparing method
  • Hollow micro-ball containing phosphazene and preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] In a 500 ml flask, 0.5 g (1.44 mmol) of hexachlorocyclotriphosphazene and 1.08 g (4.32 mmol) of 4,4'-dihydroxydiphenyl sulfone were dissolved in 250 ml of acetone, and then 0.87 g ( 8.64 mmol) acid-binding agent triethylamine was added to the above reaction system; under the action of 100w ultrasound, reacted at room temperature for 2 hours. After the reaction, the white powder was obtained by centrifugation; washed three times with acetone and three times with deionized water, then placed in an aqueous solution with a pH value of 7.0, stirred for 72 hours at 80°C for controlled hydrolysis, and then centrifuged After separation and drying, 0.82 g of hollow microspheres containing phosphazene were obtained.

[0023] Fig. 1 is the field emission scanning electron micrograph of the phosphazene-containing hollow microspheres obtained in Example 1, and Fig. 2 is the transmission electron micrograph of the phosphazene-containing hollow microspheres obtained in Example 1, and ...

Embodiment 2

[0027] In a 500 ml flask, 0.5 g (1.44 mmol) of hexachlorocyclotriphosphazene and 1.08 g (4.32 mmol) of 4,4'-dihydroxydiphenyl sulfone were dissolved in 250 ml of acetone, and then 0.87 g ( 8.64 mmol) acid-binding agent triethylamine was added to the above reaction system; under the action of magnetic stirring, the reaction was carried out at room temperature for 5 hours. After the reaction, the white powder was obtained by centrifugation; washed three times with acetone and three times with deionized water, then placed in an aqueous solution with a pH value of 7.0, stirred for 72 hours at 80°C for controlled hydrolysis, and then centrifuged After separation and drying, 0.86 g of hollow microspheres containing phosphazene can be obtained by centrifugation. Electron micrographs show that the diameter of the microsphere is 1.0-1.2 microns, and the diameter of the inner hollow is 250-350 nanometers. Spectrum analysis shows that its structure is the cross-linked condensation struc...

Embodiment 3

[0029] The equipment and preparation process described in Example 1 were adopted, except that the reaction temperature was carried out at the reflux temperature of acetone to obtain 0.85 g of hollow microspheres. The analysis of the experimental results shows that the diameter of the microsphere is 1.3-1.5 microns, and the inner hollow diameter is 400-450 nanometers. The spectrum analysis shows that its structure is a cross-linking of hexachlorocyclotriphosphazene and 4,4'-dihydroxydiphenylsulfone condensation structure.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
diameteraaaaaaaaaa
diameteraaaaaaaaaa
Login to view more

Abstract

The present invention discloses a kind of phosphazenes-containing hollow microsphere as shown in the following figure, and its preparation method; specifically, the diameter of the hollow microsphere is 0.3-2.0mu m, and the internal hollow diameter of the hollow microsphere is 100-800 nm. The phosphazenes-containing hollow microsphere which has a body-type crosslinking structure, can be produced by crosslinking condensation reaction under the function of acid binding agent, and controllable hydrolysis, in sequence, between hexachlorocyclotriphosphazene and 4, 4'-dihydroxy diphenyl sulfone; the preparation method is novel, simple and feasible, which can be large scale prepared in industrial applications.The phosphazenes-containing hollow microsphere can be used in controlling drug release, efficient catalyst carriers, new photoelectric material, flame retardant materials, etc.

Description

Technical field: [0001] The invention relates to a polymer microsphere and a preparation method thereof, in particular to a phosphazene-containing hollow microsphere and a preparation method thereof. Background technique: [0002] In recent years, various nanomaterials with special structures and special shapes have attracted widespread attention, and hollow microsphere structure materials are one of them. Hollow microspheres are evolved from core / shell composite structure materials, and their properties can be controlled by adjusting the structure, size and composition of heterogeneous core / shell composite particles, so as to realize their optical, thermal, electrical, Extensive tailoring of magnetic and catalytic properties. Due to the characteristics of low density and high specific surface of the material of this type of structure, and its hollow part can accommodate a large number of guest molecules or large-sized guests, it can produce some peculiar properties based o...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): C08G79/02C08J9/00A61K47/34C08G79/025
Inventor 朱䶮黄小彬唐小真
Owner SHANGHAI JIAO TONG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap