Eyes preparation for divergent pupil and its making method

Abstract

The invention is concerned with the method of preparation of the Mydriasis ophthalmic preparation. It is the kind of ophthalmic preparation that in liquid form before dripping into eyes but turns to gelatin postural after. It contents Mydriasis agent as the active material and other supplementary materials, such as poloxamer, carbomer, Deacetylcephalomannine Gellan Gum, transition regulator and medicinal acceptable antiseptic, isoosmotic adjustment, PH regulator and injection usage water. It can use of optometry, pre-operation naydriasis, etc. The advantages of the invention are: highly biocompatibility, low pungency, and long lasting.

Description

technical field

[0001] The invention relates to an ophthalmic preparation for dilating mydriasis, especially a preparation which is a low-viscosity liquid in vitro and undergoes phase transition in vivo into a solidified or viscous preparation and a preparation method thereof. Background technique

[0002] At present, most of the mydriatic agents commonly used in clinical practice appear in traditional dosage forms such as eye drops and eye ointment. Eye drops are the most commonly used topical dosage forms in ophthalmology. %, so it is necessary to increase the frequency of eye drops, which is inconvenient to use, and some eye drops enter the blood circulation of the whole body through the nasolacrimal duct, which may easily cause adverse reactions. Although eye ointment can avoid the defect that eye drops can easily cause systemic adverse reactions, its drug release is slow, and it needs to be used a few days in advance when optometry, which brings great troubles to life. ...