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Eyes preparation for divergent pupil and its making method

A technology of ophthalmic preparations and modulators, which is applied in the fields of medical formulas, sensory diseases, drug combinations, etc., can solve the problems of affecting the appearance and vision, the difficulty of uniform distribution of drugs, and the inaccurate control of dosage, so as to improve patient compliance and Effects of tolerance, low toxicity, and ease of spreading

Inactive Publication Date: 2007-11-21
RUIQIAO MEDICAL SCI & TECH SUZHOU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are also ophthalmic gel products on the market, but most of them are viscous and semi-solid. If the gel is directly dropped into the eye, the drug is not easy to distribute evenly due to the lack of good spreadability of the gel in the eye. It cannot be controlled accurately, and may affect the appearance and vision, so further improvement is needed

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Take 39Kg of water for injection, add 0.5Kg of atropine sulfate, stir to dissolve. Take 9Kg of poloxamer, sprinkle it into the above solution, and let it stand overnight; then add 0.005Kg of benzalkonium chloride, 0.4Kg of sodium chloride, and 2.5Kg of polysorbate 20, stir to dissolve, and adjust the pH. The solution was filtered through a 0.22 μm microporous membrane, and water was added from the filter to a total of 50Kg. Sampling is carried out for quality identification, and after passing the test, it is subpackaged in eye drop bottles under a sterile environment, and then packaged to obtain the product.

Embodiment 2

[0042] Take 39Kg of water for injection, add 0.5Kg of atropine sulfate, stir to dissolve. Take 8Kg of poloxamer, 0.15Kg of carbomer, and 0.5Kg of polyethylene glycol (PEG4000) and sprinkle them into the above solution, let stand overnight, then add 0.005Kg of benzalkonium chloride, stir to dissolve, and adjust the pH. The solution was filtered through a 0.22 μm microporous membrane, and water was added from the filter to a total of 50Kg. Sampling is carried out for quality identification, and after passing the test, it is subpackaged in eye drop bottles under a sterile environment, and then packaged to obtain the product.

Embodiment 3

[0044] Take 39Kg of water for injection, add 0.25Kg of tropicamide, stir to dissolve. Take 8Kg of poloxamer and 0.15Kg of carbomer and sprinkle into the above solution, let it stand overnight, then add 0.005Kg of benzalkonium chloride, stir to dissolve, and adjust the pH. The solution was filtered through a 0.22 μm microporous membrane, and water was added from the filter to a total of 50Kg. Sampling is carried out for quality identification, and after passing the test, it is subpackaged in eye drop bottles under a sterile environment, and then packaged to obtain the product.

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PUM

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Abstract

The invention is concerned with the method of preparation of the Mydriasis ophthalmic preparation. It is the kind of ophthalmic preparation that in liquid form before dripping into eyes but turns to gelatin postural after. It contents Mydriasis agent as the active material and other supplementary materials, such as poloxamer, carbomer, Deacetylcephalomannine Gellan Gum, transition regulator and medicinal acceptable antiseptic, isoosmotic adjustment, PH regulator and injection usage water. It can use of optometry, pre-operation naydriasis, etc. The advantages of the invention are: highly biocompatibility, low pungency, and long lasting.

Description

technical field [0001] The invention relates to an ophthalmic preparation for dilating mydriasis, especially a preparation which is a low-viscosity liquid in vitro and undergoes phase transition in vivo into a solidified or viscous preparation and a preparation method thereof. Background technique [0002] At present, most of the mydriatic agents commonly used in clinical practice appear in traditional dosage forms such as eye drops and eye ointment. Eye drops are the most commonly used topical dosage forms in ophthalmology. %, so it is necessary to increase the frequency of eye drops, which is inconvenient to use, and some eye drops enter the blood circulation of the whole body through the nasolacrimal duct, which may easily cause adverse reactions. Although eye ointment can avoid the defect that eye drops can easily cause systemic adverse reactions, its drug release is slow, and it needs to be used a few days in advance when optometry, which brings great troubles to life. ...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K47/34A61P27/08A61K47/10A61K47/26
Inventor 汪世琼陈坚
Owner RUIQIAO MEDICAL SCI & TECH SUZHOU
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