Self microemulsion preparation of Rubescensin A, and preparation method

Abstract

The present invention discloses a rabdosia rubescens extract microemulsion preparation and its preparation method. It is formed from rabdosia rubescens extract, oil phase, surfactant and assistant of surfactant. The described oil phase is one kind selected from transacylated corn oil or midchain fatty triglyceride or their mixture; the described surfactant is one kind selected from polyoxyethylenated castor oil, polyoxyethylene hydrogenated castor oil, polyglycol-8-glycerocaprylic acid / caprate or their mixture, and the assistant of surfactant is one kind selected from dicarboxyl mono-ethyl ether ester, 1-2-propylene glycol and polyethylene glycol 400 or their mixture.

Description

technical field

[0001] The invention belongs to the field of pharmaceutical preparations, and relates to an oridonin self-microemulsion drug delivery system and a preparation method thereof. Background technique

[0002] Rabdosia rubescens (Hemsl1) Hara (synonym Isodon rubescens (Hemsl1) C1Y1Wu et Hsuan), is a plant of the genus Lamiaceae, which is widely distributed in the Yellow River Basin and the vast areas to the south of China. Sweet and bitter in taste, slightly cold in nature, it has the functions of clearing away heat and relieving exterior, reducing inflammation and relieving pain, invigorating stomach, activating blood circulation and anti-tumor. Oridonin (Oridonin) is a natural compound of kaurene diterpenoids extracted and isolated from Oridonin. It is a colorless prismatic crystal with a very bitter taste and is insoluble in water. The methyl-conjugated cyclopentanone structure is the anti-cancer active center, and the effect disappears when the ring is split ...

Examples

Embodiment 1

[0020] Dissolve 1 mg of Rubescensin A in 3 g of monoethyl ether oxalate, add 1 g of acyl-transferred corn oil, 6 g of polyoxyethylene castor oil, and mix well by ultrasonic.

Embodiment 2

[0022] Dissolve 1 mg of Rubescensin A in 3 g of monoethyl ether oxalate, add 1 g of Labrafac CC, 6 g of polyoxyethylene castor oil, and mix well by ultrasonic.

Embodiment 3

[0024] Dissolve 1 mg of oridonin in 3 g of monoethyl ether oxalate, add 0.5 g of acyl-transferred corn oil, 0.5 g of Labrafac CC, 6 g of polyethylene glycol-8-glycerol caprylic acid / capric acid ester, and mix well by ultrasonic That's it.

technical field

[0001] The invention belongs to the field of pharmaceutical preparations, and relates to an oridonin self-microemulsion drug delivery system and a preparation method thereof. Background technique

[0002] Rabdosia rubescens (Hemsl1) Hara (synonym Isodon rubescens (Hemsl1) C1Y1Wu et Hsuan), is a plant of the genus Lamiaceae, which is widely distributed in the Yellow River Basin and the vast areas to the south of China. Sweet and bitter in taste, slightly cold in nature, it has the functions of clearing away heat and relieving exterior, reducing inflammation and relieving pain, invigorating stomach, activating blood circulation and anti-tumor. Oridonin (Oridonin) is a natural compound of kaurene diterpenoids extracted and isolated from Oridonin. It is a colorless prismatic crystal with a very bitter taste and is insoluble in water. The methyl-conjugated cyclopentanone structure is the anti-cancer active center, and the effect disappears when the ring is split ...

Examples

Embodiment 1

[0020] Dissolve 1 mg of Rubescensin A in 3 g of monoethyl ether oxalate, add 1 g of acyl-transferred corn oil, 6 g of polyoxyethylene castor oil, and mix well by ultrasonic.

Embodiment 2

[0022] Dissolve 1 mg of Rubescensin A in 3 g of monoethyl ether oxalate, add 1 g of Labrafac CC, 6 g of polyoxyethylene castor oil, and mix well by ultrasonic.

Embodiment 3

[0024] Dissolve 1 mg of oridonin in 3 g of monoethyl ether oxalate, add 0.5 g of acyl-transferred corn oil, 0.5 g of Labrafac CC, 6 g of polyethylene glycol-8-glycerol caprylic acid / capric acid ester, and mix well by ultrasonic That's it.

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