Extractive of red sage root of Chinese traditional medicine, and preparation method

A technology of extract and salvia miltiorrhiza, applied in the field of extract and its preparation, can solve the problems of large amount of use, complicated process route, high production cost, etc.

Inactive Publication Date: 2007-12-26
北京凯瑞创新医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But this method has multiple defects, mainly comprising: 1, water decoction and concentrating process can make salvianolic acid B destroy more than 50%; There are many types and a large amount of use, so the production cost is very high
Therefore, there is no real active part of total salvianolic acid at present, that is, there is no extract or its product, wherein the content of total salvianolic acid can account for more than 60% of its total solid content

Method used

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Examples

Experimental program
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Effect test

Embodiment 2

[0035]Example 2: Take 1000 g of Danshen medicinal material, add 8 times the amount of acid water with a pH of 2 to extract twice, and soak for 4 hours each time, and stir once every half an hour, combine the extracts, filter; add zinc sulfate to the filtrate solution and keep the pH value at 6.2 to 6.7 until no more precipitate occurs, centrifuge and separate the precipitate; add 10% sulfuric acid solution to dissolve the precipitate, extract 3 times with ethyl acetate, 1 times the amount each time, combine, and recover ethyl acetate Esters, spray-dried to obtain Danshen extract. Determined by high performance liquid chromatography, the total salvianolic acid content reaches 70%.

Embodiment 3

[0037] Take 1000g of Salvia miltiorrhiza, add acid water with pH=3 and infiltrate until the zinc chloride solution is added without precipitation, filter, add sodium hydroxide test solution to the filtrate to adjust the pH value to 7, add 1mol / L magnesium sulfate solution, At the same time, add sodium hydroxide test solution to adjust the pH to 6.5. When the pH of the solution is 6.5, add magnesium sulfate solution without precipitation. Centrifuge, separate the precipitate, dissolve the precipitate with 4 times the amount of 15% hydrochloric acid solution, extract 2 times with ethyl acetate, each time is 2 times the amount of 10% hydrochloric acid solution, combine the ethyl acetate solution, recover, spray dry, Danshen extract. Measured by ultraviolet spectrophotometry, the content of its total salvianolic acid reaches 72%.

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Abstract

The present invention discloses an extract of Chinese medicinal material salvia root, its total salviolic acid content can be up to above 50%, at the same time said invention also discloses a method for preparing said extract. Said method includes the following steps: using weak acid to extract the Chinese medicinal material salvia root, adding metal ions into the extract, making salviolic acid be precipitated, separating precipitate, using acid solution to dissolve said precipitate, then using ethylacetate to make extraction, recovering ethyl acetate so as to obtain the invented salvia root extract.

Description

technical field [0001] The invention relates to a medicinal extract derived from plant materials and a preparation method, in particular to an extract of salvia miltiorrhiza and its preparation method, belonging to the field of traditional Chinese medicine. Background technique [0002] Salvianolic acid, also known as salvianolic acid, is a water-soluble active ingredient of salvia miltiorrhiza, and belongs to phenolic acid compounds. At present, there are more studies on total salvianolic acid (total salvianolic acid), salvianolic acid A (salvianolic acid A, SalA) and salvianolic acid B (salvianolic acid B, SalB). The earliest discovered chemical name of Danshensu is β-3,4-dihydroxybenyl lactic acid (β-3,4-dihydroxybenyl lactic acid), which is the basic chemical structure of various salvianolic acids. SalA is formed by the condensation of one molecule of danshensu and two molecules of caffeic acid; Sal B is formed by the condensation of three molecules of danshensu and one...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61P9/00C07B63/00
Inventor 高淑英
Owner 北京凯瑞创新医药科技有限公司
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