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Liposome combined medicine and method for preparing the same

A liposome and drug technology, applied in liposome delivery, pharmaceutical formulations, antibacterial drugs, etc., can solve the problems of blood white blood cell and thrombocytopenia, abnormal liver and kidney function, easy to cause phlebitis, etc., and achieve the goal of drug The effect of reducing the amount of distribution, reducing the number of medications, and enhancing the curative effect

Inactive Publication Date: 2008-01-02
HUNAN KANGDU PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The severe toxic and side effects exposed clinically by the existing clindamycin, fleroxacin, ciprofloxacin, and levofloxacin drugs include: nausea, vomiting, abdominal pain, diarrhea, and enteritis in the gastrointestinal tract; toxicity to the liver and kidneys causes abnormal liver and kidney function, or even damage; blood leukocytes and thrombocytopenia caused by toxicity to the blood system; allergic reactions cause rash, itchy skin, hives, dyspnea, and even anaphylactic shock; pain during injection Strong and prone to phlebitis
Most of the above toxic side effects are positively related to dose

Method used

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  • Liposome combined medicine and method for preparing the same
  • Liposome combined medicine and method for preparing the same
  • Liposome combined medicine and method for preparing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] The formula that present embodiment adopts is as follows:

[0046] Mixture of soybean lecithin and dipalmitoylcholine (3:1) 0.05mol

[0047] Cholesterol and β-sitosterol mixture (1:1) 0.05mol

[0048] Clindamycin Hydrochloride and Levofloxacin Lactate Random Ratio Mixture 200mg

[0049] Reduced glutathione and tiopronin mixture (molar ratio 1:3) 20g

[0050]Polyethylene glycol 6000 0.005mol

[0051] Sodium glutamate 30g

[0052] The number of grams contained in the mixture of Pluronic F68 and hypromellose in any ratio in 100ml liquid medicine is 0.2%-0.7%g / ml

[0053] Phosphate buffer 0.015M pH3.0-5.5 added to 1000ml

[0054] The 200 mg of the arbitrary ratio mixture of clindamycin hydrochloride and levofloxacin lactate is calculated based on the amount of clindamycin and levofloxacin.

[0055] Preparation steps:

[0056] (1) Dissolve the mixture of soybean lecithin and dipalmitoylcholine, the mixture of cholesterol and β-sitosterol in an appropriate amount of ch...

Embodiment 2

[0067] The formula that present embodiment adopts is as follows:

[0068] Mixture of soybean lecithin and dipalmitoylcholine (5:1) 0.1mol

[0069] Cholesterol and β-sitosterol mixture (2:1) 0.1mol

[0070] Clindamycin Hydrochloride and Levofloxacin Hydrochloride Random Ratio Mixture 400mg

[0071] Reduced glutathione and tiopronin mixture (molar ratio 1:5) 30g

[0072] Polyethylene glycol 6000 0.001mol

[0073] Sodium glutamate 40g

[0074] The number of grams contained in the mixture of Pluronic F68 and hypromellose in any ratio in 100ml liquid medicine is 0.2%-0.7%g / ml

[0075] Phosphate buffer 0.015M pH3.0-5.5 added to 1000ml

[0076] The 200 mg of the arbitrary ratio mixture of clindamycin hydrochloride and levofloxacin hydrochloride is calculated based on the amount of clindamycin hydrochloride and levofloxacin hydrochloride.

[0077] Preparation steps: with reference to Example 1.

[0078] Pharmacodynamic verification test:

[0079] Infect the mouse model with pn...

Embodiment 3

[0082] The formula that present embodiment adopts is as follows:

[0083] Soy lecithin and dipalmitoylcholine mixture 4:1) 0.2mol

[0084] Cholesterol and β-sitosterol mixture (2:1) 0.2mol

[0085] Clindamycin Phosphate and Levofloxacin Lactate Random Ratio Mixture 600mg

[0086] Reduced glutathione and tiopronin mixture (molar ratio 1:4) 30g

[0087] Polyethylene glycol 6000 0.02mol

[0088] Sodium glutamate 50g

[0089] The number of grams contained in the mixture of Pluronic F68 and hypromellose in any ratio in 100ml liquid medicine is 0.2%-0.7%g / ml

[0090] Phosphate buffer 0.015M pH3.0-5.5 added to 1000ml

[0091] The 200 mg of the arbitrary ratio mixture of clindamycin phosphate and levofloxacin lactate is calculated based on the amount of clindamycin and levofloxacin.

[0092] Preparation steps: see Example 1.

[0093] Pharmacodynamic verification test:

[0094] Infect the mouse model with pneumococcus, and inject it via intravenous injection 6 hours after infec...

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PUM

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Abstract

The invention relates to a liposome compound and the preparing method, which is characterized in that said liposome compound comprises one or several compounds of clindamycinum, fleraxacin, levofloxacin hydrochloride and ciprofloxacin. The toxicity of product is low, medical effect is high and effective prevention of drug resistance generation by pathogenic microorganism.

Description

technical field [0001] The invention relates to a liposome combination medicine and a preparation method thereof. Background technique [0002] The existing antimicrobial drugs clindamycin, fleroxacin, ciprofloxacin, and levofloxacin are all broad-spectrum and highly effective antibacterial drugs. However, their clinical use faces two major crises: one is that the dosage is increasing, and the other is that the toxicity and side effects are obvious. The severe toxic and side effects exposed clinically by the existing clindamycin, fleroxacin, ciprofloxacin, and levofloxacin drugs include: nausea, vomiting, abdominal pain, diarrhea, and enteritis in the gastrointestinal tract; toxicity to the liver and kidneys causes abnormal liver and kidney function, or even damage; blood leukocytes and thrombocytopenia caused by toxicity to the blood system; allergic reactions cause rash, itchy skin, hives, dyspnea, and even anaphylactic shock; pain during injection Strong and prone to ph...

Claims

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Application Information

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IPC IPC(8): A61K9/127A61K31/496A61K31/7056A61K47/34A61P31/04A61K47/10
Inventor 蔡海德
Owner HUNAN KANGDU PHARMA
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