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Ceanothus polysaccharide sulfate and its preparing process and application

A technology of rhamnosan and sulfate, applied in blood diseases, extracellular fluid diseases, drug combinations, etc., can solve the problems that rhamnosulphate has not been reported, and achieve good market application prospects

Inactive Publication Date: 2008-01-16
OCEAN UNIV OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there is no report about rhamnosan sulfate

Method used

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  • Ceanothus polysaccharide sulfate and its preparing process and application
  • Ceanothus polysaccharide sulfate and its preparing process and application
  • Ceanothus polysaccharide sulfate and its preparing process and application

Examples

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Embodiment Construction

[0010] Weigh the dried seaweed and add 10-60 times the weight of seaweed to soak and homogenate, stir and extract at room temperature for 0.1-2 hours, centrifuge and discard the clear liquid, take the sediment containing seaweed and add 10-60 times the weight of seaweed 60 times of water, stirring and extracting in a water bath at 60-100°C for 1-10 hours, centrifuging to discard impurities, taking the clear liquid, concentrating the obtained clear liquid under reduced pressure, and then performing dialysis or ultrafiltration to remove salt, and remove the salt After the polysaccharide solution is concentrated under reduced pressure, it is separated by ion-exchange chromatography column Q-Sepharose Fast Flow, eluted with distilled water and 0.01-5.0mol / L sodium chloride aqueous solution in sequence, the polysaccharide solution is collected, concentrated under reduced pressure, and passed through The gel chromatographic column Sephacryal S-400 HR is further separated, eluted with...

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PUM

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Abstract

Disclosed is a cascara glycan sulfate, which is characterized in that the cascara glycan sulfate is a long chain sulfate polysaccharide which is composed of a rhamnose and whose molecular formula is (C6H7O4R2) n. When in preparation, seaweed is soaked with water in homogenate and is extracted in room temperature so that precipitate is separated, and then the water is added into the precipitate which is extracted by heating to separate out clear liquid which is then concentrated and desalted. Desalted solution is concentrated and is separated by an ion exchange chromatographic column and a gel chromatographic column sequentially; at last, polysaccharide solution obtained from the above process is concentrated and dried. The invention is a sulfate polysaccharide compound with strong polyanion property, can be used for preparation of a novel anticoagulant drug or anti-thrombosis drug, and has a good market application prospect.

Description

technical field [0001] The invention relates to a rhamnosan sulfate and a preparation method and application thereof. Background technique [0002] Thromboembolic disease is one of the major lethal diseases in modern society, and it tends to increase year by year with the change of human diet structure. At present, the annual global market value of anticoagulant drugs is about US$4 billion, increasing at a rate of 13% year by year; the global market value of antithrombotic drugs is about US$12 billion, increasing at an annual rate of 15%. Therefore, the existing anticoagulant and antithrombotic drugs are far from meeting the growing clinical needs. Moreover, studies have found that heparin, which has been widely used as an anticoagulant drug for more than 70 years, has various side effects, such as inducing thrombocytopenia, bleeding, ineffective against congenital thrombin deficiency, and has no ability to inhibit the combination of thrombin and fibrin. In addition, the c...

Claims

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Application Information

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IPC IPC(8): C08B37/04A61K31/737A61P7/02
Inventor 毛文君
Owner OCEAN UNIV OF CHINA
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