Surface plasma body resonant vibration and flexible flat plate wave combined detection biologic sensor

A surface plasmon and biosensor technology, applied in the field of biosensors, can solve the problems of inability to know whether the absorption layer contains too much moisture or other non-specific substances, large deviation of test results, inability to distinguish non-specific adsorption, etc.

Inactive Publication Date: 2008-01-23
CHANGCHUN INST OF OPTICS FINE MECHANICS & PHYSICS CHINESE ACAD OF SCI
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Problems solved by technology

A major limitation of this detection method is that it cannot distinguish non-specific adsorption. The change of SPR incident light resonance angle is a function of the thickness and refract

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  • Surface plasma body resonant vibration and flexible flat plate wave combined detection biologic sensor

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Embodiment Construction

[0010] The structure of the biosensor of the present invention will be further described in detail with reference to the embodiments given in the accompanying drawings.

[0011] Referring to Fig. 1, a biosensor for joint detection of surface plasmon resonance and flexible plate wave is composed of an optical sensing part and an acoustic wave sensing part, and the optical sensing part is composed of a half cylindrical prism 1, a sticker The optical borosilicate glass sheet 2 placed on the black surface of the prism and the gold film 9 plated on the middle part of the outer surface of the optical borosilicate glass sheet 2 are composed of; The aluminum ground layer 4 laid on the bottom surface of 6, the aluminum nitride piezoelectric film 5 laid on the aluminum ground layer 4, and the interdigitated electrode 7 laid on the outer surface of the aluminum nitride piezoelectric film 5 constitute; The optical borosilicate glass sheet 2 on the surface of the semi-cylindrical prism 1 i...

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Abstract

The invention relates to a biologic detecting sensor combining surface plasma resonance with flexible plate wave that is applicable for detecting the biologic affinity reaction feature in such fields as clinic inspection, medicine screening, environment and food inspection, etc., which comprises an optic sensing component and a sound wave sensor, between which a sample pond for bearing the object to be detected is arranged. By the biologic sensor, a plurality of parameters of the object can be measured in the same test condition, and the accuracy of the physical characterization of the biologic reacting object can be greatly improved.

Description

technical field [0001] The invention relates to a biosensor suitable for detection of bioaffinity response characteristics in the fields of clinical testing, drug screening, environment, food testing, etc., especially a biosensor capable of synchronously detecting changes in physical quantities such as the mass and thickness of a bioreaction conjugate, and a dielectric constant. biological sensor. Background technique [0002] The detection of biological affinity is not limited to the chemical process of biological reactions, but to detect the process and results of biological reactions based on various information of biological reactions, such as light, heat, field effects, and mass changes. ratio, the detection time can be greatly shortened. In bioaffinity detection, transduction methods such as optics, electrochemistry, and acoustic waves have the advantages of high sensitivity and real-time continuous detection, and have become the mainstream of current biosensing techn...

Claims

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Application Information

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IPC IPC(8): G01N33/48G01N21/55G01N29/00G01N21/552
Inventor 吴一辉李锋郝鹏黎海文张平
Owner CHANGCHUN INST OF OPTICS FINE MECHANICS & PHYSICS CHINESE ACAD OF SCI
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