Surface plasma body resonant vibration and flexible flat plate wave combined detection biologic sensor

Abstract

The invention relates to a biologic detecting sensor combining surface plasma resonance with flexible plate wave that is applicable for detecting the biologic affinity reaction feature in such fields as clinic inspection, medicine screening, environment and food inspection, etc., which comprises an optic sensing component and a sound wave sensor, between which a sample pond for bearing the object to be detected is arranged. By the biologic sensor, a plurality of parameters of the object can be measured in the same test condition, and the accuracy of the physical characterization of the biologic reacting object can be greatly improved.

Description

technical field [0001] The invention relates to a biosensor suitable for detection of bioaffinity response characteristics in the fields of clinical testing, drug screening, environment, food testing, etc., especially a biosensor capable of synchronously detecting changes in physical quantities such as the mass and thickness of a bioreaction conjugate, and a dielectric constant. biological sensor. Background technique [0002] The detection of biological affinity is not limited to the chemical process of biological reactions, but to detect the process and results of biological reactions based on various information of biological reactions, such as light, heat, field effects, and mass changes. ratio, the detection time can be greatly shortened. In bioaffinity detection, transduction methods such as optics, electrochemistry, and acoustic waves have the advantages of high sensitivity and real-time continuous detection, and have become the mainstream of current biosensing techn...

AI Technical Summary

Problems solved by technology

A major limitation of this detection method is that it cannot distinguish non-specific adsorption. The change of SPR incident light resonance angle is a function of the thickness and refractive index of the absorbing layer. It is impossible to know whether the absorbing layer contains too much water or other non-specific substances. Often cause large deviations in test results

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