New compound and method for preparing same

A compound, chloroform technology, applied in the direction of active ingredients of heterocyclic compounds, organic chemistry, etc., to achieve the effect of low cost and high purity

Active Publication Date: 2008-01-30
BEIJING WBL PEKING UNIV BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Nitrogen-(1-(tetrahydro-5-oxofuran-2)-ethyl)acetazolamide isolated from Xuezhikang crude drug has not been reported in the literature

Method used

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  • New compound and method for preparing same
  • New compound and method for preparing same
  • New compound and method for preparing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033]

[0034] N-(1(tetrahydro-5-oxofuran-2-yl)ethyl)acetamide(C-6)

[0035] The separation method is as follows:

[0036] Take 2kg of Xuezhikang crude drug, and then use 3 times the amount of petroleum ether and chloroform to sonicate 4 times respectively, 20min / time. Combine the extracts, recover the solvent, and obtain petroleum ether part P and chloroform part C;

[0037] 250 g of part C was subjected to silica gel column chromatography, and chloroform-methanol gradient eluted to obtain chloroform part C-I, 95:5 chloroform-methanol part C-II, 90:10 chloroform-methanol part C-III, and methanol part C-IV ;

[0038] Part C-II was eluted with a gradient of 90:10-0:100 petroleum ether-ethyl acetate; the fraction eluted with 80:20 petroleum ether-ethyl acetate was chromatographed on a silica gel column, and similar fractions were combined and obtained from sections 9-11. The fraction obtained compound C-6, was applied to a Sephadex LH-20 column and eluted with 50:50 chlor...

Embodiment 2

[0039] Example 2: C-6 Derivatives

[0040]

[0041] sodium 5-acetamido-4-hydroxyhexanoate

[0042]

[0043] C-6 sodium 5-acetamido-4-hydroxyhexanoate

Embodiment 3

[0044] Example 3: C-6 Derivatives

[0045]

[0046] methyl 5-acetamido-4-hydroxyhexanoate

[0047]

[0048] C-6 methyl 5-acetamido-4-hydroxyhexanoate

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PUM

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Abstract

The invention discloses a novel compound and preparation thereof. Researches prove that, Xuezhikang special made Hongqu can obviously decrease the occurrence rate of coronary heart disease attack and the general death rate. The chemical components of Xuezhikang are researched and ten components are separated from the Xuezhikang and evaluated, wherein, N-(1-(tetrahydro-5-oxyfuran-2)-ethyl) acetazoamide is a new compound.

Description

technical field [0001] The present invention relates to a new compound and its preparation method. Background technique [0002] Xuezhikang special red yeast rice is made according to the method of patent ZL97103970.4. [0003] Xuezhikang capsule is a traditional Chinese medicine preparation made of specially made red yeast rice, which has clinical effects such as lowering blood fat, anti-atherosclerosis, anti-cancer, and anti-osteoporosis. Clinical studies have proved that it can significantly reduce the incidence of coronary heart disease events and reduce the total mortality rate. The compound 3β-hydroxy-5α, 8β-cyclodioxergoster-6,22-diene isolated from the Xuezhikang raw material drug has a strong anticancer activity on L-1210 cell line and can inhibit MCF-7 human mammary gland Cancer and the growth of Walder256 sarcoma cell lines, also have inhibitory effect on human liver cancer PLC / PRF5 and KB cells, and can also selectively enhance the inhibitory effect of linoleic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D307/33A61K31/34
Inventor 段震文郭树仁马学敏
Owner BEIJING WBL PEKING UNIV BIOTECH
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