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Ftibamzone chrisma with propanediol as co-solvent

A technology of propylene glycol and phthalocyanine, applied in the directions of ointment delivery, antiviral agent, aerosol delivery, etc., can solve problems such as limitations, achieve the effect of overcoming skin irritation, and ensuring efficacy and stability

Active Publication Date: 2008-02-13
BEIJING UNION PHARMA FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The phthalobutanol ointment produced by the applicant of this patent also uses dimethyl sulfoxide as a cosolvent, which is greatly restricted when entering the European and American markets

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] step 1

[0047] Weigh 10 grams of phthalobutanol raw material, add 100 grams of propylene glycol, 50 grams, 50 grams, 200 grams in total, heat and dissolve, and set aside for use. (Propylene glycol accounts for 20% of the prescription in step 1)

[0048] step 2

[0049] oil phase

[0050] Each component is weighed according to the prescription amount, and the oil phase and the water phase are respectively heated in a container until dissolved. Quickly pour the water phase into the oil phase, and stir quickly to fully blend the oil and water phases. Pour the phthalobutane solution dissolved in step 1 and stir, and form a paste as the temperature decreases. Repeat the ointment in the colloid mill for 2-3 times to make the ointment more delicate. Sub-package, capping, get the phthalide ointment of the present invention, put in a cool place for preservation.

Embodiment 2

[0052] step 1

[0053] Weigh 10 grams of phthalobutanol raw material, add 100 grams of propylene glycol, 50 grams, 50 grams, 200 grams in total, heat and dissolve, and set aside for use. (Propylene glycol accounts for 20% of the prescription in step 1)

[0054] Step 2 prescription (based on 1000 grams of Phthaltin Ointment, the weight unit is grams)

[0055] oil phase

[0056] Each component is weighed according to the prescription amount, and the oil phase and the water phase are respectively heated in a container until dissolved. Quickly pour the water phase into the oil phase, and stir quickly to fully blend the oil and water phases. Pour the phthalobutane solution dissolved in step 1 and stir, and form a paste as the temperature decreases. Repeat the ointment in the colloid mill for 2-3 times to make the ointment more delicate. Sub-package, capping, get the phthalide ointment of the present invention, put in a cool place for preservation.

Embodiment 3

[0058] step 1

[0059] Weigh 10 grams of phthalobutanol raw material, add 100 grams of propylene glycol, 50 grams, 50 grams, 200 grams in total, heat and dissolve, and set aside for use. (Propylene glycol accounts for 20% of the prescription in step 1)

[0060] Step 2 prescription (based on 1000 grams of Phthaltin Ointment, the weight unit is grams)

[0061] oil phase

[0062] Each component is weighed according to the prescription amount, and the oil phase and the water phase are respectively heated in a container until dissolved. Quickly pour the water phase into the oil phase, and stir quickly to fully blend the oil and water phases. Pour the phthalobutane solution dissolved in step 1 and stir, and form a paste as the temperature decreases. Repeat the ointment in the colloid mill for 2-3 times to make the ointment more delicate. Sub-package, capping, get the phthalide ointment of the present invention, put in a cool place for preservation.

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PUM

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Abstract

The present invention discloses a new phthiobuaone ointment. In the phthiobuaone ointment, the active component is phthiobuaone. The propanediol is the cosolvent. A new prescription comprises the octadecanol, the liquid paraffin, the albolene, the laurel alcohol sodium sulfate, the nipagin acetic ester and the distilled water, which not only guarantee the effect and stability of the phthiobuaone ointment, but also overcome skin irritation of the phthiobuaone ointment, which takes dimethyl sulfoxide as the cosolvent in current technology.

Description

technical field [0001] The present invention relates to a kind of new phthalobutanol ointment. The phthalobutamol ointment uses phthalobutamol as an active ingredient, propylene glycol as a cosolvent, and a new prescription together with stearyl alcohol, liquid paraffin, white vaseline, sodium lauryl sulfate, ethylparaben and distilled water. Background technique [0002] Phthalin is a new type of antiviral drug developed by the Chinese Academy of Medical Sciences in the 1970s. It is an ideal drug for treating herpes zoster and also for skin diseases such as condyloma acuminata, molluscum contagiosum, flat warts and common warts. However, in the prior art, phthalobutanol ointment all uses dimethyl sulfoxide as a cosolvent, and dimethyl sulfoxide has certain skin irritation, so external use is prohibited in developed regions such as Europe and America. The phthalobutanol ointment produced by the applicant of this patent also uses dimethyl sulfoxide as a cosolvent, which is g...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/4704A61K47/14A61P17/12A61P17/00A61P31/12
Inventor 何秀峰王爱国吴文英
Owner BEIJING UNION PHARMA FACTORY