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Ftibamzone chrisma with propanediol as co-solvent

A technology of propylene glycol and phthalobutanol, which is applied in the direction of ointment delivery, antiviral agent, aerosol delivery, etc., can solve problems such as limitations, achieve the effect of overcoming skin irritation and ensuring drug efficacy and stability

Active Publication Date: 2010-12-22
BEIJING UNION PHARMA FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The phthalobutanol ointment produced by the applicant of this patent also uses dimethyl sulfoxide as a cosolvent, which is greatly restricted when entering the European and American markets

Method used

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  • Ftibamzone chrisma with propanediol as co-solvent
  • Ftibamzone chrisma with propanediol as co-solvent
  • Ftibamzone chrisma with propanediol as co-solvent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] step 1

[0047] Weigh 10 grams of the raw material of Phthalobutanol, add 100 grams of propylene glycol, 50 grams, and 50 grams total of 200 grams of propylene glycol in portions after heating and dissolving for use. (In step 1, propylene glycol accounts for 20% of the prescription)

[0048] Step 2

[0049]

[0050] Each component is weighed according to the prescribed amount, and the oil phase and water phase are separately heated in the container to dissolve. Pour the water phase into the oil phase quickly, and stir quickly to make the oil and water phases fully melt. Pour the phthalimin solution that has been dissolved in step 1 into stirring, and form a paste as the temperature decreases. Repeat the ointment in the colloid mill 2-3 times to make the ointment body more delicate. Distribute and seal to obtain the phthalimin ointment of the present invention, and store it in a cool place.

Embodiment 2

[0052] step 1

[0053] Weigh 10 grams of the raw material of Phthalobutanol, add 100 grams of propylene glycol, 50 grams, and 50 grams total of 200 grams of propylene glycol in portions after heating and dissolving for use. (In step 1, propylene glycol accounts for 20% of the prescription)

[0054] Step 2 Recipe (based on 1000 grams of thalbumin ointment, the weight unit is grams)

[0055]

[0056] Each component is weighed according to the prescribed amount, and the oil phase and water phase are separately heated in the container to dissolve. Pour the water phase into the oil phase quickly, and stir quickly to make the oil and water phases fully melt. Pour the phthalimin solution that has been dissolved in step 1 into stirring, and form a paste as the temperature decreases. Repeat the ointment in the colloid mill 2-3 times to make the ointment body more delicate. Distribute and seal to obtain the phthalimin ointment of the present invention, and store it in a cool place.

Embodiment 3

[0058] step 1

[0059] Weigh 10 grams of the raw material of Phthalobutanol, add 100 grams of propylene glycol, 50 grams, and 50 grams total of 200 grams of propylene glycol in portions after heating and dissolving for use. (In step 1, propylene glycol accounts for 20% of the prescription)

[0060] Step 2 Recipe (based on 1000 grams of thalbumin ointment, the weight unit is grams)

[0061]

[0062] Each component is weighed according to the prescribed amount, and the oil phase and water phase are separately heated in the container to dissolve. Pour the water phase into the oil phase quickly, and stir quickly to make the oil and water phases fully melt. Pour the phthalimin solution that has been dissolved in step 1 into stirring, and form a paste as the temperature decreases. Repeat the ointment in the colloid mill 2-3 times to make the ointment body more delicate. Distribute and seal to obtain the phthalimin ointment of the present invention, and store it in a cool place.

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Abstract

The present invention discloses a new phthiobuaone ointment. In the phthiobuaone ointment, the active component is phthiobuaone. The propanediol is the cosolvent. A new prescription comprises the octadecanol, the liquid paraffin, the albolene, the laurel alcohol sodium sulfate, the nipagin acetic ester and the distilled water, which not only guarantee the effect and stability of the phthiobuaone ointment, but also overcome skin irritation of the phthiobuaone ointment, which takes dimethyl sulfoxide as the cosolvent in current technology.

Description

Technical field [0001] The present invention relates to a new phthalimin ointment. The phthalimin ointment uses phthalimin as an active ingredient, propylene glycol as a cosolvent, and forms a new prescription together with stearyl alcohol, liquid paraffin, white petrolatum, sodium lauryl sulfate, ethyl paraben and distilled water. Background technique [0002] Phthalobutanol is a new type of antiviral drug developed by the Chinese Academy of Medical Sciences in the 1970s. It is an ideal drug for the treatment of herpes zoster. It can also be used for condyloma acuminatum, molluscum contagiosum, flat warts and common warts. However, in the prior art, phthalobutylene ointment all uses dimethyl sulfoxide as a co-solvent, which has a certain skin irritation, and it is prohibited for external use in developed regions such as Europe and the United States. The phthalobutylene ointment produced by the applicant of this patent also uses dimethyl sulfoxide as a co-solvent, which is great...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K31/4704A61K47/14A61P17/12A61P17/00A61P31/12
Inventor 何秀峰王爱国吴文英
Owner BEIJING UNION PHARMA FACTORY