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Ftibamzone chrisma with PEG-200 as co-solvent

A technology of PEG-200 and phthalocyanine, which is used in ointment delivery, aerosol delivery, medical preparations with non-active ingredients, etc., can solve problems such as limitations, overcome skin irritation, and ensure efficacy and stability. Effect

Active Publication Date: 2008-02-13
BEIJING UNION PHARMA FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The phthalobutanol ointment produced by the applicant of this patent also uses dimethyl sulfoxide as a cosolvent, which is greatly restricted when entering the European and American markets

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] step 1

[0047] Weigh 10 grams of phthalobutanol raw material, add 100 grams of PEG-200, 50 grams, 50 grams, 200 grams in total, heat to dissolve and set aside for use. (PEG-200 accounts for 20% of the prescription in step 1)

[0048] step 2

[0049] oil phase

[0050] Each component is weighed according to the prescription amount, and the oil phase and the water phase are respectively heated in a container until dissolved. Quickly pour the water phase into the oil phase, and stir quickly to fully blend the oil and water phases. Pour the phthalobutane solution dissolved in step 1 and stir, and form a paste as the temperature decreases. Repeat the ointment in the colloid mill for 2-3 times to make the ointment more delicate. Sub-package, capping, get the phthalide ointment of the present invention, put in a cool place for preservation.

Embodiment 2

[0052] step 1

[0053] Weigh 10 grams of phthalobutanol raw material, add 100 grams of PEG-200, 50 grams, 50 grams, 200 grams in total, heat to dissolve and set aside for use. (PEG-200 accounts for 20% of the prescription in step 1)

[0054] Step 2 prescription (based on 1000 grams of Phthaltin Ointment, the weight unit is grams)

[0055] oil phase

[0056] Each component is weighed according to the prescription amount, and the oil phase and the water phase are respectively heated in a container until dissolved. Quickly pour the water phase into the oil phase, and stir quickly to fully blend the oil and water phases. Pour the phthalobutane solution dissolved in step 1 and stir, and form a paste as the temperature decreases. Repeat the ointment in the colloid mill for 2-3 times to make the ointment more delicate. Sub-package, capping, get the phthalide ointment of the present invention, put in a cool place for preservation.

Embodiment 3

[0058] step 1

[0059] Weigh 10 grams of phthalobutanol raw material, add 100 grams of PEG-200, 50 grams, 50 grams, 200 grams in total, heat to dissolve and set aside for use. (PEG-200 accounts for 20% of the prescription in step 1)

[0060] Step 2 prescription (based on 1000 grams of Phthaltin Ointment, the weight unit is grams)

[0061] oil phase

[0062] Each component is weighed according to the prescription amount, and the oil phase and the water phase are respectively heated in a container until dissolved. Quickly pour the water phase into the oil phase, and stir quickly to fully blend the oil and water phases. Pour the phthalobutane solution dissolved in step 1 and stir, and form a paste as the temperature decreases. Repeat the ointment in the colloid mill for 2-3 times to make the ointment more delicate. Sub-package, capping, get the phthalide ointment of the present invention, put in a cool place for preservation.

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PUM

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Abstract

The present invention discloses a new phthiobuaone ointment. In the phthiobuaone ointment, the active component is phthiobuaone. The PEG-200 is the cosolvent. A new prescription comprises the octadecanol, the liquid paraffin, the albolene, the lauryl alcohol sodium sulfate, the nipagin acetic ester and the distilled water, which not only guarantee the effect and stability of the phthiobuaone ointment, but also overcome skin irritation of the phthiobuaone ointment taking PEG-200 as the cosolvent in current technology.

Description

technical field [0001] The present invention relates to a kind of new phthalobutanol ointment. The phthalobutamol ointment uses phthalobutamol as the active ingredient, PEG-200 as the co-solvent, and forms a new formula together with stearyl alcohol, liquid paraffin, white vaseline, sodium lauryl sulfate, ethylparaben and distilled water. prescription. Background technique [0002] Phthalin is a new type of antiviral drug developed by the Chinese Academy of Medical Sciences in the 1970s. It is an ideal drug for treating herpes zoster and also for skin diseases such as condyloma acuminata, molluscum contagiosum, flat warts and common warts. However, in the prior art, phthalobutanol ointment all uses dimethyl sulfoxide as a cosolvent, and dimethyl sulfoxide has certain skin irritation, so external use is prohibited in developed regions such as Europe and America. The phthalobutanol ointment produced by the applicant of this patent also uses dimethyl sulfoxide as a cosolvent,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/4704A61K47/34A61P17/00A61P17/12A61K47/10
Inventor 何秀峰王爱国吴文英
Owner BEIJING UNION PHARMA FACTORY