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Nano montmorillonite for restraining bacterium and method of preparing the same

A kind of montmorillonite and nanotechnology, which is applied in the direction of antibacterial drugs, inorganic non-active ingredients, active ingredients of tetracycline, etc., can solve the problems of unforeseeable technical effects and inferring antibacterial drugs, etc.

Inactive Publication Date: 2010-07-14
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are many kinds of anti-infective substances, and the chemical structure and properties of each drug are different. Not all anti-infective drugs can be inserted and anchored into the montmorillonite layer, so it cannot be deduced from the technical scheme disclosed by Xi Lifei Antibacterial drug / montmorillonite slow-release system, let alone its technical effect

Method used

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  • Nano montmorillonite for restraining bacterium and method of preparing the same
  • Nano montmorillonite for restraining bacterium and method of preparing the same
  • Nano montmorillonite for restraining bacterium and method of preparing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] 1. Preparation of Na-montmorillonite: the raw material montmorillonite (mainly containing Na + , Ca 2+ , Mg 2+ Ion) 20g was stirred in 500mL NaCl saturated deionized aqueous solution to form a stable suspension; the suspension was stirred at 35°C for 5 hours. Filter with suction, and then wash the filtrate 4 times with deionized water. The precipitate was vacuum-dried at 70°C to constant weight, and ball-milled to a particle size of 20-30 μm to obtain Na-montmorillonite (the XRD pattern is shown in figure 1 , whose infrared spectrum is shown in figure 2 ).

[0039]2. Preparation of miconazole nitrate-modified Na-montmorillonite: Mix 10 g of Na-montmorillonite obtained above with 6 g of miconazole nitrate, add 200 ml of absolute ethanol, and stir the mixture at room temperature for 5 hours. Suction filtration, then wash the filtrate several times with absolute ethanol, detect the absence of miconazole nitrate in the filtrate by ultraviolet spectrophotometer, dry th...

Embodiment 2

[0041] 1. Prepare Na-montmorillonite: with embodiment 1.

[0042] 2. Preparation of miconazole nitrate-modified Na-montmorillonite: Mix 10 g of Na-montmorillonite obtained above with 8 g of miconazole nitrate, add 200 ml of absolute ethanol, and stir the mixture at room temperature for 2 hours. Suction filtration, then wash the filtrate several times with absolute ethanol, detect the absence of miconazole nitrate in the filtrate by ultraviolet spectrophotometer, dry the precipitate in vacuum at 60°C to constant weight, and ball mill until the particle size is 20-30 μm to obtain nitric acid Miconazole modified montmorillonite. All the filtrates were collected and filtered with a 0.45um microporous membrane, and an appropriate amount of the filtrate was used to measure the ultraviolet light absorbance value with a Biomat-5 ultraviolet spectrophotometer, and the remaining drug 6g was calculated. That is, 2 g of miconazole nitrate was intercalated in 10 g of Na-montmorillonite, a...

Embodiment 3

[0044] 1. Prepare Na-montmorillonite: with embodiment 1.

[0045] 2. Preparation of miconazole nitrate-modified Na-montmorillonite: Mix 10 g of Na-montmorillonite obtained above with 10 g of miconazole nitrate, add 200 ml of absolute ethanol, and stir the mixture at room temperature for 5 hours. Suction filtration, then wash the filtrate several times with absolute ethanol, detect the absence of miconazole nitrate in the filtrate by ultraviolet spectrophotometer, dry the precipitate in vacuum at 60°C to constant weight, and ball mill until the particle size is 20-30 μm to obtain nitric acid Miconazole modified montmorillonite. All the filtrates were collected and filtered with a 0.45um microporous membrane, and an appropriate amount of the filtrate was used to measure the ultraviolet light absorbance value with a Biomat-5 ultraviolet spectrophotometer, and the remaining drug 6g was calculated. That is, 4 g of miconazole nitrate was intercalated in 10 g of Na-montmorillonite, ...

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Abstract

The invention provides nano bacterium-resisting montmorillonite, which comprises montmorillonite 100 weight parts and antibacterial drugs 10-45 weight parts. The preparing process comprises steps of mixing Na-montmorillonite and antibacterial drugs, charging solvent and stirring, forming stable suspension, filtering, removing the solvent, finally drying and ball-grinding.

Description

[0001] The filing date of the original application is 2005.9.27, the application number is 200510037525.3, and the invention name is anti-infection modified montmorillonite and its preparation method technical field [0002] The invention relates to a medical preparation, in particular to an anti-infection material modified montmorillonite and a preparation method thereof. Background technique [0003] Montmorillonite, also known as bentonite, is a layered silicate with large pores in its molecular space. Its structural unit is composed of two silicon-oxygen tetrahedrons sandwiching a silicon-oxygen octahedron. Its chemical formula is (M+nH 2 O)(Al 4 -yMgy)Si 8 o 20 (OH) 4 (where M=Na + , Ca 2+ , Mg 2+ etc.), its structural sheet is nanoscale, and the distance between the unit layers is about 1 nanometer, which is easy to exchange with inorganic, alkyl quaternary ammonium salts or other organic cations and neutral molecules to form organic montmorillonite. [0004] "...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/02A61K31/65A61P31/04
Inventor 路新卫韦莉萍邱玉超谢少玉
Owner SOUTHERN MEDICAL UNIVERSITY