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Effervescence dispersible tablet

A technology of dispersible tablets and effervescent agents, which is applied in the field of new drug dosage forms, can solve problems such as many restrictions on developers, and achieve the effects of improved dispersibility, easy oral administration, and small dosage

Inactive Publication Date: 2010-09-29
YUNNAN BAIYAO GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This is detrimental to the development of new dosage forms of drugs, and developers are subject to too many restrictions

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] 1. Chinese medicine licorice effervescent dispersible tablets

[0029] Licorice extract medicine 112.5g

[0030] Citric acid 10g

[0031] Sodium bicarbonate 13g

[0032] Cross-linked polyvinylpyrrolidone (PVPP) 10g

[0033] Microcrystalline Cellulose (MCC) 20g

[0034] Anselmi 8g

[0035] Lactose 22.5g

[0036] Povidone K 30 4g

[0037] The above prescriptions were prepared separately according to the aforementioned three methods, and 1000 effervescent dispersible tablets of licorice with a tablet weight of 0.2 g can be prepared.

[0038] 2. Sample dispersion uniformity detection

[0039] The test standard for the uniformity of dispersion of effervescent dispersible tablets is: take 2 effervescent dispersible tablets, put them in 100ml water at 20℃±1℃, shake for 3 minutes, they should all disintegrate and pass through the second sieve. Table 1 shows the test results of licorice effervescent dispersible tablets.

[0040] Table 1. Experimental results of the di...

Embodiment 2

[0043] 1. Traditional Chinese Medicine Sanhuang Effervescent Dispersible Tablets

[0044] Rhubarb 300g, berberine hydrochloride 5g, scutellaria baicalensis extract 21g. Rhubarb was added with 30% ethanol for reflux extraction for three times, filtered, combined the filtrate, recovered ethanol and concentrated under reduced pressure to prepare a powder, berberine hydrochloride and scutellaria baicalensis extract were mixed uniformly to obtain 100 g of extract powder for later use.

[0045] Sanhuang extract powder 100g

[0046] Tartaric acid 30g

[0047] Sodium bicarbonate 36g

[0048] Sodium Carboxymethyl Starch (CMS-Na) 20g

[0049] Low-substituted hydroxypropyl cellulose (L-HPC) 40g

[0050] Aspartame 10g

[0051] Lactose (lactose) 28g

[0052] Mannitol 28g

[0053] Povidone K 30 8g

[0054] The above prescriptions were prepared separately according to the aforementioned three methods, and 1000 Sanhuang effervescent dispersible tablets each weighing 0.3g can be p...

example 3

[0060] 1. Western medicine famotidine effervescent dispersible tablets

[0061] Famotidine 20g

[0062] Anhydrous citric acid 9g

[0063] Sodium bicarbonate 12g

[0064] Sodium Carboxymethyl Starch (CMS-Na) 7g

[0065] Low-substituted hydroxypropyl cellulose (L-HPC) 14g

[0066] Aspartame 1.2g

[0067] Dextrin 86.8g

[0068] Povidone K 30 2g

[0069] The above prescriptions were prepared separately according to the aforementioned three methods, and 1000 famotidine effervescent dispersible tablets each weighing 0.15 g can be prepared.

[0070] 2. Sample dispersion uniformity detection

[0071] The test standard for the uniformity of dispersion of effervescent dispersible tablets is: take 2 effervescent dispersible tablets, put them in 100ml water at 20℃±1℃, shake for 3 minutes, they should all disintegrate and pass through the second sieve. Table 3 shows the test results of the samples of Famotif effervescent dispersible tablets.

[0072] Table 3. Experimental results of...

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Abstract

The present invention relates to a new preparation of a Chinese medicine. The present invention particularly relates to a novel preparation of a drug with the effervescent tablet property and the dispersing agent property. In the effervescent dispersing tablet of the present invention, the weight ratio of each components are as following, which comprises 5 percentage to 60 percentage of effervescent agent, 3 percentage to 30 percentage of effervescing agent, 3 percentage to 30 percentage of disintegrant, 3 percentage to 30 percentage of excipient of the hydrophilic medicine, 1 percentage to 5percentage of correctant. The effervescent dispersing tablet of the present invention is a novel preparation of the Chinese medicine, which has the effervescent tablet property and the dispersing agent property. The present medicine is a tablet, which can produce the gas in the water, which can disaggregate quickly and disperse evenly. The present invention is a novel preparation of the medicine,which can generate the gas; as a result the medicine can disaggregate more quickly. The drug loading dosage of the agent is large, which is beneficial for improving the dispersion uniformity, the dissolution and the bioavailability of the medicine. The present invention has the characteristics of convenience for oral administration and small dose. The present invention can sufficiently display the drug efficacy in order to meet the drug requirement of the patients.

Description

Technical field [0001] The invention relates to a new dosage form of traditional Chinese medicine, in particular to a new dosage form of medicine with both the characteristics of an effervescent tablet and the characteristics of a dispersant. technical background [0002] An effervescent tablet is a form of traditional Chinese medicine. It has been clearly stipulated in the 2005 edition of the Chinese Pharmacopoeia. An effervescent tablet refers to a tablet that contains sodium bicarbonate and organic acids and can produce gas when exposed to water. It has been widely used in traditional Chinese medicine formulations, such as Xia Sangju effervescent tablets, Ginkgo Vitamin C effervescent tablets, Xiaoer Kechuan effervescent tablets, Shuanghuanglian effervescent tablets, etc. There are more than 120 related patents. Dispersible tablets are a western medicine type, which has been clearly stipulated in the 2005 edition of the Chinese Pharmacopoeia. Dispersible tablets refer to table...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/46A61K47/12A61K47/04A61K47/36A61K47/30A61K36/53A61K36/484A61K11/04A61K29/00
Inventor 王真张立群万近福
Owner YUNNAN BAIYAO GROUP