Nucleic acid aptamer with high specificity and high affinity to human breast carcinoma tissue, preparation method and application thereof

A nucleic acid aptamer, a technology for human breast cancer, applied in the field of breast cancer diagnosis and targeted therapy, to achieve the effect of easy labeling and high stability
CN101148666AInactive Publication Date: 2008-03-26CHINA NAT ACAD NANOTECH & ENG +1
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
CHINA NAT ACAD NANOTECH & ENG
Publication Date
2008-03-26
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to one kind of nucleic acid gamete with high specificity and affinity to human breast cancer tissue and its preparation process and application. The nucleic acid gamete includes one DNA sequence and one RNA sequence and may be combined to human breast cancer tissue specifically, so that it may be applied for diagnosis and targeting treatment of human breast cancer. The nucleic acid gamete has high specificity and affinity to human breast cancer tissue and no reaction to health mammary gland tissue. The present invention also relates to derived sequences, including modified sequence, of the nucleic acid gamete.
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Description

(1) Technical field:

[0001] The present invention relates to the field of biotechnology, in particular to the preparation of a group of nucleic acid aptamers with high specificity and high affinity for human breast cancer tissue by using the SELEX technology (that is, phylogenetic evolution index enrichment technology) in molecular biology technology, and the obtained The nucleic acid aptamer-derived sequence and modified sequence are used for the diagnosis and targeted therapy of breast cancer. (two) background technology:

[0002] Breast cancer is the malignant tumor with the highest incidence rate among women in the world. According to authoritative medical statistics, one person dies of breast cancer every 13 minutes in the world. Breast cancer has become an important disease that seriously threatens women's health. With the development of the national economy and the improvement of people's living standards, the incidence and mortality of breast cancer in my country are...

Claims

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