41 results about "Mammary Gland Tissue" patented technology

The invention provides novel compositions, methods and uses, for the diagnosis, prognosis, prediction, prevention and aid in treatment of malignant neoplasia such as breast cancer, ovarian cancer, gastric cancer, colon cancer, esophageal cancer, mesenchymal cancer, bladder cancer or non-small cell lung cancer. Genes that are chromosomally amplified in breast tissue of breast cancer patients are disclosed. Further disclosed are chromosomally amplified genes and non-amplified genes that correlate to Taxane resistance, Taxane benefit or adverse Taxane reaction, which can be used as an aid to make therapy dicisions.

Methods, systems, and apparatuses for automatically identifying glandular regions and tubule regions in a breast tissue sample are provided. An image of breast tissue is analyzed to detect nuclei and lumen candidates, identify tumor nuclei and true lumen from the candidates, and group tumor nuclei with neighboring tumor nuclei and lumina to define tubule glandular regions and non-tubule glandular regions of the image. Learnt supervised classifiers, such as random forest classifiers, can be applied to identify and classify the tumor nuclei and true lumina. Graph-cut methods can be applied to group the tumor nuclei and lumina and to define the tubule glandular regions and non-tubule glandular regions. The analysis can be applied to whole slide images and can resolve tubule areas with multiple layers of nuclei.

The computer aided method of predicting mammary cancer risk includes the following steps: partitioning the mammary gland tissue area in X-ray image regularly into small areas and calculating the density characteristic value of the small areas; selecting the initial suspicious small areas with the preset density characteristic value for further research; judging the final suspicious small areas based on the information in the corresponding areas and the adjacent areas on two frames of images; and judging the near term mammary cancer risk of the testee based on the existence of the marked final suspicious small areas and predicting the mammary cancer position in case of existing final suspicious small areas. The present invention has high objectivity, high accuracy and high effectiveness in predicting mammary cancer risk.

The invention discloses a three-dimensional high-definition mammary gland imager in the biological medical imaging domain, which is characterized by the following: judging pathologic position and degree of mammary gland tissue according to optical parameter according to grey, tissue structure and size semi-quantitatively or qualitatively; adopting infrared (600-900nm) as light source; modulating space of irradiated light through coded aperture without harmful detecting; forming digital infrared optical scanning hologram; utilizing digital decoded technique to extract the information of galactophore tissue; displaying three-dimensional high-definition image.

The present invention relates to compositions and methods for inducing mammary epithelial cell differentiation in mammalian subjects. More specifically, the present invention relates to methods for inducing mammary epithelial cell differentiation which comprise increasing the levels of galanin in the mammary tissue of the subject. In one aspect the present invention relates to a method of increasing milk production in a lactating mammal which comprises increasing the level of galanin or an analog thereof in the mammal. In another aspect the present invention relates to a method of enhancing mammary development in a mammal, the method comprising administering to the mammal galanin or an analog thereof in conjunction with prolactin or an analog thereof. In yet another aspect the present invention relates to a method for inhibiting mammary epithelial tumours by administering an inhibitorially effective therapeutic amount of galanin or an analog thereof.

The invention discloses a method for displaying soft copy of a mammary gland X-line graph, in which a weighting function used for representing the importance of pixel values in a mammary gland zone and a monotonic increasing dynamic range conversion function are constructed by performing statistics to obtain a probability density column diagram of pixel value x in the mammary gland zone of the mammary gland X-line graph, each pixel value in the mammary gland X-line graph is mapped to displayable grayscale by using the dynamic range conversion function to form a display graph, substantially each pixel value in the mammary gland X-line graph is subject to non-linear mapping to displayable grayscale, as the mapping relationship adopts non-linear mapping, the result obtained by the invention can show different importance of message of different mammary gland tissue parts, thus realizing clear expression of important diagnostic message; in addition, by display graph by the method of the invention, the display effect of the mammary gland substantial zone can be vastly improved, and simultaneously the display effect of the mammary gland outline can be maintained, thus keeping distinct andvisible mammary gland outline.

The invention discloses an integrated mammary gland infrared diagnostic device with the camera shooting function. The integrated mammary gland infrared diagnostic device comprises a shell (5) and is characterized in that an infrared camera (1), a mammary gland infrared diagnostic probe (11) and an infrared light diode (6) for providing infrared light for the infrared camera (1) and the mammary gland infrared diagnostic probe (11) are installed on the shell (5), the infrared camera (1), the mammary gland infrared diagnostic probe (11) and the infrared light diode (6) are all connected with a control board (9) installed in the shell (5) electrically, and the control board (9) is electrically connected with a control panel (4) and connected with an image processing system through a connecting wire (10). According to the integrated mammary gland infrared diagnostic device, the camera and a mammary gland diagnostic device body are creatively combined, clinical examination can be conveniently carried out, an examination doctor only needs to operate the infrared probe with one hand to be capable of completing examination and image collection on the mammary gland tissue, and the examination efficiency and the examination effect are improved.

The invention provides a method for establishing a lactation model of cow mammary gland epithelial cells for researching the milk protein gene expression regulation mechanism and providing favorable conditions for testing a mammary gland expression vector. The testing method comprises the following steps: carrying out primary culture and identification of the cow mammary gland epithelial cells; determining the secretion situation of lactose by using the HPLC method; determining the secretion situation of beta-casein protein by using the HPLC method; and carrying out cryopreservation and recovery on the cells. The method adopts the tissue block method to culturing the cow mammary gland epithelial cells in different periods, compared with other primary culture methods of the mammary gland epithelial cells, such as enzyme digestion and the like, the method does not affect the activity of the mammary gland epithelial cells, the culture cost is very low, and the operation is very simple. The method realizes the continuation of normal culture of a cow mammary gland epithelial cell system, thereby property and effectively preserving a large number of precious cow mammary gland tissue materials. The method provides the important testing materials and a technical platform for researching the lactation mechanism of the cow mammary gland during the different development periods.

Mammary gland blood oxygen function imaging method and system is disclosed. The method includes irradiating mammary gland tissue with a double wavelength light source, receiving light with a detector, converting the analog signal of light strength into digital signal, performing image processing to calculate the variation in oxyhemoglobin and deoxyhemoglobin, and final mapping the the variation in oxyhemoglobin and deoxyhemoglobin to form figure. The system features its double wavelength generator connected to the light source controlling module, and its image analysis and processing system connected to the computerized central processing system. Using the imaging method and system can obtain sufficient and accurate image data for post computer image treatment and obtain raised diagnosis coincidence rate.

The invention discloses a composition with a Staphylococcus aureus resisting effect. The composition consists of general flavone of sophora flavescens and general flavone of liquorice. The general flavone parts of sophora flavescens and liquorice are prepared through extraction, extraction, enrichment and the like, and are compounded. The results of in-vitro research shows that the composition directly inhibits the growth of gram-positive bacteria such as Staphylococcus aureus and can reduce the formation of biofilms and the content of staphyloxanthin; the results of in-vivo studies prove thatthe composition can obviously reduce mammary gland alveolar hyperplasia and alveolar inflammatory cell infiltration of mice caused by Staphylococcus aureus infections, and significantly reduce the bacterium carrying amount of mouse mammary gland tissues of each model group and the content of IL-1 beta, IL-2 and TNF-alpha inflammatory factors in the mammary gland tissues. According to the invention, the comprehensive utilization of medicinal materials including sophora flavescens and liquorice and the quality and efficiency improvement of the industry can be realized; the waste is turned intothe wealth; and the composition has good economic effects and social benefits, and accords with the sustainable development strategy in China.

The invention discloses a nutritive feed additive capable of promoting the development of mammary gland of sows. The nutritive feed additive comprises the following components in parts by weight: 10-25 parts of papaya powder, 20-100 parts of expanded soybean meal, 1-5 parts of organic selenium and 3-10 parts of vitamin E. The nutritive feed additive disclosed by the invention is capable of promoting the normal metabolism of female hormones of the sows, further promoting the good development of mammary gland tissues of the sows and the normal start of a lactation function and increasing the productivity effect of livestock farms.

The invention discloses a square-wave frequency coding high-spectral imaging measurement system for mammary glands. The square-wave frequency coding high-spectral imaging measurement system is characterized in that a monochromatic light source group is distributed on one side of a mammary gland tissue sample, and a camera is distributed on the other side of the mammary gland tissue sample; various monochromatic light sources in the monochromatic light source group are densely arrayed on a hemispherical surface, and a light beam can be gathered by a lens to form a light source; a light source receiving device can be formed by the camera; the various monochromatic light sources in the monochromatic light source group can be respectively driven by square waves which have different frequencies in two-times ratio relations with one another, each pixel point in each image received by the camera is a monochromatic light combination of the corresponding monochromatic light source, and the monochromatic light combinations are transmitted through the mammary glands; the monochromatic light combinations are separated from one another by a computer, so that contribution of the various monochromatic light sources on the monochromatic light combinations can be obtained, and transmission high-spectral images of the mammary glands can be formed according to the contribution. The square-wave frequency coding high-spectral imaging measurement system has the advantages that the transmission high-speed, high-information and high-spectral images of the mammary glands can be precisely measured, the square-wave frequency coding high-spectral imaging measurement system is low in cost, convenient to apply and suitable for regular self-examination at home, and the like.

The present invention relates to the establishment method of mammary gland bioreactor. Target gene is introduced through transfection liquid to the lactiferous duct or mammary gland tissue of animal for expressing the target gene in the mammary gland under the control of lactoprotein specificity regulating and controlling sequence. The method features the transfection liquid with added stem cell supporting factor for transfecting mammary gland stem cell inside animal body through introducing the transfection liquid to animal body in different bearing periods of the animal. The establishment method of mammary gland bioreactor has high success rate, easy operation, short production period and low cost.

The invention discloses a C-shaped infrared mammary gland detector. From top to bottom, the C-shaped infrared mammary gland detector comprises a camera platform, a supporting platform, an adjusting device, a power control device and a travel device, wherein the supporting platform comprises a horizontal supporting piece and a vertical supporting piece; the power control device is a power switch; the travel device includes rolling wheels; and the camera platform comprises a C-shaped projecting camera and a display which are mutually connected. The mammary gland detector provided by the invention is convenient to operate and uniform in illumination, accurate in data and labor-saving, and mammary gland images under an infrared light source can be conveniently collected. Both the C-shaped projecting camera and the display have function of increasing and decreasing light sources, zooming in and zooming out images, picking up images and freezing images, and the C-shaped projecting camera and the display are convenient to control. The mammary gland images can be directly projected on breasts, or the mammary gland images are transmitted to the display or the mammary gland images are transmitted to external equipment; with the application of the three ways, the mammary gland tissue images can be observed; and the C-shaped infrared mammary gland detector is convenient for observation and is high in early cancer detection accuracy rate.

The invention relates to a recombinant goat fetal fibroblast for expressing an antithrombin III. A rhATIII modified fibroblast SM1sCh-AT is preserved in a China Center for Type Culture Collection (CCTCC) on August 15, 2012, and the preservation number is CCTCC C 2012103. By means of a structured rhATIII mammary gland specific expression vector, a target gene rhATIII is integrated on genomes of the goat fetal fibroblast. Specific efficient expression of the target gene in goat mammary gland tissues can be guided by cloning 5' and 3' regulation areas of a goat beta casein gene at two ends of the rhATIII gene. The recombinant goat fetal fibroblast containing the target gene rhATIII can be used as a nucleus donor cell for the structuring of transgenic cloning embryos through nuclear transfer, transgenic cloning embryos are obtained through a somatic cell nuclear transfer method, obtained embryos are transferred into receptor goat uteri, and accordingly, rhATIII modified milk goat bioreactor can be produced efficiently.

The mammary gland-specific expression systems developed by the present inventors, named pGbc, pGbc_L and pGbc_S were deposited under the Budapest Treaty on the International Recognition of the Deposit of Microorganisms for the Purpose of Patent Procedure in the Korean Collection for Type Cultures (KCTC), Korean Research Institute of Bioscience and Biotechnology at 52, Oun-dong, Yusong-Ku, Taejon 305–333, Republic of Korea, on Aug. 17, 1998, and the accession deposit Nos. KCTC 0515BP, 0514BP and 0513BP were issued, respectively. All restructions on the availability to the public of the deposited materials will be irrevocably removed upon the granting of a patent. The systems of the present invention make it possible that desired proteins are produced by expression in mammary gland tissue-derived animal cells or through the milk secreted from the transgenic animals with the expression systems, thereby solving the above-mentioned problems, that is, the activity sustenance, production cost, and isolation and purification of the desired proteins.

The invention discloses a health-care bra for preventing and treating mastoptosis and relaxation and a production method of the health-care bra. The health-care bra comprises a silica gel pad, a bra fabric and a health-care formula, and the health-care formula comprises the following raw materials by weight: 10-20 g of codonopsis pilosula, 6-15 g of Chinese yam, 6-15 g of schisandra chinensis, 10-20 g of angelica sinensis, 6-15 g of goji, 6-15 g of safflower, 10-20 g of semen cuscutae, 6-15 g of sunflower seeds, 10-20 g of honey, 6-15 g of poria cocos, 6-15 g of radix rehmanniae preparata, 6-15 g of rhizoma cyperi, 10-20 g of black sesame, 6-15 g of Chinese dates, 6-15 g of black beans, 6-15 g of fructus amomi and 6-15 g of peach kernels. The beneficial effects are that the health-care bra can activate mammary gland cells, promote blood circulation and microcirculation, provide sufficient nutrition for mammary gland tissues of breasts, improve cell metabolism, promote contraction of the mammary gland tissues and tighten the breasts step by step, so that the effects of preventing and treating mastoptosis and relaxation are achieved, and the consolidation effect can be achieved by continuously using the preparation method.

The invention relates to an automatic auxiliary detection system for breast tumors based on diffusion magnetic resonance images, which is characterized in that an automatic lesion detection system including a threshold equipotential processing module, an averaging module and a parameterized fitting module is set; threshold equipotential processing The module uses the threshold equipotential algorithm to classify the selected b-value image to obtain the equipotential threshold, where b is the diffusion-sensitive gradient parameter; the averaging module is used to perform arithmetic mean processing on the pixel signal intensity selected under the equipotential threshold , to obtain the average signal intensity of the pixels in this area; the parameterized fitting module performs nonlinear fitting calculation on the average signal intensity under the allelic threshold, and obtains the apparent diffusion coefficient ADC and apparent diffusion Kurtosis AK. The invention can segment the tumor area, quantitatively calculate the diffusion-related parameters, and discriminate the benign and malignant attributes of breast tumors without trauma.

The present invention provides a novel method for detecting mammary cancer cells which uses, as an index, an expression level of a specific gene in human mammary cancer tissue (or cells). The method is characterized by including (1) measuring an expression level of a gene having a specific nucleotide sequence in human mammary cancer tissue (or cells), (2) measuring an expression level of the gene in human normal mammary gland tissue (or cells), and (3) detecting mammary cancer cells on the basis of the difference between measurement values obtained in (1) and (2).

The invention discloses a flexible cylindrical array of a capacitive micro-machined ultrasonic transducer, and belongs to the technical field of MEMS. The cylindrical array is formed by butting and splicing a plurality of same curved surface arrays, each curved surface array is mainly composed of a mold, a flexible PCB and a CMUT wafer which are stacked, the CMUT wafer is cut to form a plurality of linear arrays, PDMS is filled among the linear arrays, the top surface of the CMUT wafer is provided with a metal upper electrode, and the bottom surface of the CMUT wafer is provided with a metal lower electrode. The flexible cylindrical array has the advantages of high density and high consistency, can surround the periphery of the mammary gland for screening, can realize detection of mammary gland tissues in a CMUT cylindrical array space with the aperture of 20cm, and has good cost and performance advantages in the field of ultrasonic imaging.

The invention provides a physical breast enhancement device, belongs to beauty equipment and is mainly used in the field of expanding mammary gland and breast skin tissue. The physical breast enhancement technical scheme aims at overcoming the defects of a traditional breast enhancement treatment means and is economical, simple and healthy. In order to achieve the purpose, according to the technical scheme, cushion rings, plastic breast shields and high-elasticity bras of medical silica gel / TPE / TPU / TPR materials are used for form a closed environment for breast tissue, air in the breast shields is sucked through a micro computer controller so that constant negative pressure can be formed around breasts, and local blood circulation is accelerated so that the purpose of promoting mammary gland tissue proliferation can be achieved. The physical breast enhancement device is mainly used for overcoming the congenital mammary gland development deficiency, mastatrophy caused by lactation, asymmetry of two-side breasts and other mammary gland tissue defects to perform proliferation.

Mammary gland blood oxygen function imaging method and system is disclosed. The method includes irradiating mammary gland tissue with a double wavelength light source, receiving light with a detector, converting the analog signal of light strength into digital signal, performing image processing to calculate the variation in oxyhemoglobin and deoxyhemoglobin, and final mapping the the variation in oxyhemoglobin and deoxyhemoglobin to form figure. The system features its double wavelength generator connected to the light source controlling module, and its image analysis and processing system connected to the computerized central processing system. Using the imaging method and system can obtain sufficient and accurate image data for post computer image treatment and obtain raised diagnosis coincidence rate.

The invention provides a method for carrying out tumor diagnosis by utilizing ultrasonic image fusion data, which comprises the following steps of: transmitting ultrasonic waves to mammary gland tissues to obtain reflected wave signals and transmitted wave signals aiming at different directions of the mammary gland tissues, and covering all-directional angles of the mammary gland tissues in the different directions; performing image reconstruction on the obtained reflected wave signal and transmitted wave signal to obtain a sound velocity image, a reflected image and an attenuated image; performing image fusion on the sound velocity image, the reflection image and the attenuation image to obtain a fused image; the three-dimensional ultrasonic image data corresponding to the mammary gland tissue can be generated only through one-time scanning, some key information can be displayed in an overlapped mode after the three images are fused, imaging performance of different signals on the mammary gland tissue can be displayed on the same image, and doctors can find specific performance of diseases easily.

The invention discloses microRNAs (micro Ribonucleic Acids) in the mammary gland tissues of the Jinhua pig. The invention utilizes the sequencing technique to carry out deep sequencing on the mammary gland tissues of the Jinhua pig to obtain the sequences of mammary gland smallRNAs, and utilizes the bioinformatics method to analyze the sequences to obtain the variety and copy number of Jinhua pig miRNAs, so that certain predicted miRNAs in mammals, which are not included, are obtained, and the nucleotide sequences of the miRNAs are shown as SEQ ID NO:1 to SEQ ID NO:90. Certain miRNAs provided by the invention can be chosen for the research of a series of activities including porcine mammary gland lactation, lactation suppression and the like, and the microRNAs can help to increase the lactation volume of sows and the growth speed of piglets, and can also be used along with the currently discovered miRNAs in the customization of chips for the research of mammary gland activities or mammary gland diseases.

The invention discloses application of allicin in reduction of stability of lipid rafts. It is discovered that a certain dose of allicin can inhibit formation of the lipid rafts in the mammary gland tissue of a mouse and / or lower the content of the lipid rafts for the first time, and accordingly the stability of the lipid rafts in mammary gland cells is effectively lowered. Therefore, the allicincan be used as a novel inhibitor for the lipid rafts, and the technical support is provided for development of a medicine for treating the diseases related to the lipid rafts.

The invention discloses a method for assessing the health status of mammary gland and the quality of breast milk through detecting the flora composition of mammary gland or milk samples and an application of the method. The method is characterized in that the content of staphylococcus and the content of corynebacterium in flora of mammary gland tissue or milk samples, and the proportion of the staphylococcus and the proportion of the corynebacterium in the flora are detected. The detection result based on the method can be used for forecasting and assessing the morbidity risk of female mastitis (including lactation period mastitis and non-lactation period mastitis), and guiding diagnosis, treatment and prognostic assessment of the mastitis. In addition, the method can also be used for assessing the quality of the breast milk of females at the lactation period. For healthy females having morbidity risk or low breast milk quality, a dietary structure adjustment scheme can be drafted according to the inspection result, and the scheme can directly or indirectly improve the flora structure of the mammary gland and / or the breast milk, so that the corresponding preventing and health-carepurpose can be realized. According to the method disclosed by the invention, a microbiology base and an effective technique are provided for preventing and treating mastitis, and possibility is also provided for improving the quality of the breast milk.

The invention discloses a dielectric property analytical method of an isolated mammary gland. Normal gland tissues are separated in the isolated mammary gland, simple mammary gland tissues are independently in qualitative analysis under section guiding, meanwhile section information is combined inside the gland, and conductivity characteristics of glands of different age groups are further analyzed. The method is standard in operation and accurate and reliable in experimental result, and strictly controls experimental conditions. According to the method, more systematic awareness can be achieved on the dielectric property of the gland tissues, and guiding is further provided for analysis of other structures of the mammary gland or comprehensive analysis of the dielectric property of mammary gland organs.