Pharmaceutical composition containing rasagiline

A technology of composition and mixture, which is applied in the direction of drug combination, medical preparations of non-active ingredients, pharmaceutical formulas, etc., and can solve problems such as allergic reactions and diarrhea

Inactive Publication Date: 2008-04-02
BEIJING D VENTUREPHARM TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, oral administration of large amounts of mannitol can cause diarrhea and allergic reactions

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Preparation Process:

[0025] 1. Crush and sieve the raw and auxiliary materials, and set aside.

[0026] 2. Weigh the prescribed amount of rasagiline mesylate, mannitol, microcrystalline cellulose, and starch and mix them evenly according to the principle of equal addition to obtain a solid mixture.

[0027] 3. Add starch slurry to the solid mixture to granulate, dry and granulate.

[0028] 4. Calculate the yield, add micropowder silica gel, talcum powder, stearic acid, mix, and pack into capsules.

Embodiment 2

[0031] Preparation Process:

[0032] 1. Crush and sieve the raw and auxiliary materials, and set aside.

[0033] 2. Weigh the prescribed amount of rasagiline mesylate, sorbitol, microcrystalline cellulose, precrossified starch, and starch and mix them uniformly according to the principle of equal incremental addition to obtain a solid mixture.

[0034] 3. Add starch slurry to the solid mixture to granulate, dry and granulate.

[0035] 4. Calculate the yield, add micropowder silica gel, talcum powder, citric acid, mix, and compress into tablets.

Embodiment 3

[0038] Preparation Process

[0039] 1. Crush and sieve the raw and auxiliary materials, and set aside.

[0040] 2. Weigh the rasagiline mesylate, mannitol, microcrystalline cellulose, and carboxymethyl starch sodium in the prescribed amount and mix them uniformly according to the principle of equal increase to obtain a solid mixture.

[0041] 3. Add 50% ethanol to the solid mixture to granulate, dry and granulate.

[0042] 4. Calculate the yield, add essence, sucralose, menthol, magnesium stearate, citric acid, mix well, and press into tablets.

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PUM

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Abstract

The present invention discloses an oral solid medicinal combination, comprises 0.5 weight percent to 3 weight percent of rasagiline and salt of rasagiline, less than 60 weight percent of pentahydric alcohol and/or hexahydric alcohol and 0.5 weight percent to 3 weight percent of organic acid. The present invention is used for curing the Parkinsonism.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to a novel rasagiline oral solid pharmaceutical composition for treating Parkinson's disease. Background technique [0002] Parkinson's disease is the second largest neurological chronic disease after Alzheimer's disease. The onset of Parkinson's disease is mainly due to the progressive degeneration of dopaminergic neurons in the substantia nigra-striatum system of the brain, resulting in striatum Depletion of the neurotransmitter dopamine in the major motor areas of the brain. [0003] The current drugs for the treatment of Parkinson's disease include levodopa, DA receptor agonists, MAO-B inhibitors, and COMT inhibitors. Since the 1960s, levodopa has always been the main force in the treatment of Parkinson's disease. Although levodopa has its irreplaceable advantages, it is only used as a precursor of DA to supplement DA content, which is prone to serious complications. disease. C...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K9/48A61K31/13A61K47/38A61P25/16
Inventor 岳本花
Owner BEIJING D VENTUREPHARM TECH DEV
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