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Vitamin D* solid dispersion peridium patch and method for preparing the same

A technology of solid dispersion and solid dispersion carrier, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas. The effect of uniform quality appearance

Active Publication Date: 2008-04-02
重庆市天龙牧业科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] Due to the aforementioned reasons, the problems of denaturation, deterioration, etc. cannot be effectively solved by the general method of making tablets, and the produced D 2 Tablets cannot be quantitatively and qualitatively detected, resulting in uncontrollable quality, which will limit its clinical application

Method used

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  • Vitamin D* solid dispersion peridium patch and method for preparing the same
  • Vitamin D* solid dispersion peridium patch and method for preparing the same
  • Vitamin D* solid dispersion peridium patch and method for preparing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] Vitamin D 2 Solid dispersion coated tablet, which consists of:

[0071] Vitamin D 2 0.3125g

[0072] PEG-6000 100g

[0073] Starch 2500g

[0074] Calcium hydrogen phosphate 2250g

[0075] Ethanol 75g

[0076] Magnesium Stearate 100g

[0077] Talc powder 50g

[0078] A total of 10000 pieces

[0079] Prepared as follows:

[0080] 1) Weigh the prescribed amount of PEG-6000 and put it in an 80°C water bath for 40 minutes until it melts completely.

[0081] 2) Add prescribed amount of vitamin D while hot 2 , Stir quickly until the mixture is uniform, and at the same time, ultrasonic waves can be used for 5 minutes to accelerate the solid dispersion speed and dispersion rate.

[0082] 3) Put the homogeneously mixed liquid dispersion in the freezer of the refrigerator for quick freeze-drying.

[0083] 4) After freeze-drying into blocks, transfer to another wide-mouth container, and dry in a vacuum oven at 40°C for 5-6 hours.

[0084] 5) Pound the dried dispe...

Embodiment 2、3、4

[0090] The processing step of embodiment 2,3,4 is exactly the same as embodiment 1, and each component and consumption are as shown in table 1 in its prescription:

[0091] Components used in the embodiment of table 1

[0092] Example

Embodiment 5、6、7

[0094] The processing step of embodiment 5,6,7 is exactly the same as embodiment 1, and each component and consumption are as shown in table 2 in its prescription:

[0095] Components used in the embodiment of table 2

[0096] Example

5

6

7

Vitamin D 2

0.3125g

0.3125g

0.3125g

solid dispersion carrier

polyethylene glycol

100g

povidone

100g

Surfactant

100g

filler

Starch + Calcium Hydrogen Phosphate

4450g

powdered sugar

4450g

Dextrin

4450g

Adhesive

Starch slurry 50g

Starch slurry 50g

Cellulose 50g

humectant

Ethanol 75ml

Ethanol 75ml

Distilled water 75ml

lubricant

Magnesium stearate

100g

Magnesium stearate

100g

Magnesium stearate

100g

Glidant

Talc powder

50g

Micropowder silica gel

50g

hydrogenated vegetable oil

50g

disintegr...

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PUM

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Abstract

The invention relates to Vitamin D2 solid dispersion coated tablet and the preparation method, belonging to pharmaceutical preparation technical field. The tablet contains Vitamin D2 and pharmaceutical excipient, with Vitamin D2 as the active component. Every ten thousand tablets contain 0.3125g of Vitamin D2, 100g of PEG-6000, 2500g of starch, 2250g of phosphoric acid calcium hydrogen, 75ml of alcohol, 100g of magnesium stearate and 50g of talc. The invention has a simple preparation method, according to which Vitamin D2 is coated to produce tablets. The Vitamin D2 tablets prepared in the method has obvious treating effects and can be taken orally. The toxicity is low and the bioavailability is greatly enhanced. Besides, the tablet has the functions of sustaining, targeting, energy provision for human organism, etc.

Description

technical field [0001] The present invention relates to vitamin D 2 A solid dispersion coated tablet and a preparation method thereof belong to the technical field of pharmaceutical preparations. Background technique [0002] A lack of vitamin D in the body can cause rickets, tetany and rickets. Vitamin D mainly has the following physiological functions: (1) Improve the body's absorption of calcium and phosphorus, and make the levels of plasma calcium and phosphorus reach saturation. (2) promotes growth and bone calcification, and promotes healthy teeth; (3) increases phosphorus absorption through the intestinal wall and increases phosphorus reabsorption through the renal tubules; (4) maintains normal levels of citrate in the blood; (5) Prevents loss of amino acids through the kidneys. [0003] Vitamin D 2 It is mainly used for the treatment of rickets, tetany and rickets. Vitamin D 2 It is an essential vitamin for the human body and belongs to steroid hormones. Its ma...

Claims

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Application Information

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IPC IPC(8): A61K31/592A61K9/20A61K47/36A61K47/38A61K47/44A61P3/02
Inventor 刘娟
Owner 重庆市天龙牧业科技有限公司
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