Content determination method of haw and corium stomachium galli preparation

A method of determination, the technology of Hawthorn, applied in the direction of measuring devices, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problem of not finding a method for purifying a certain ingredient

Active Publication Date: 2008-04-30
云南神威施普瑞药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the preparation method of the test solution under the national drug standard about the content determination of medicinal ma

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Embodiment 1: Determination of the content of Hawthorn Neijin Oral Liquid

[0015] Take 218g of hawthorn, 141g of Tibetan calamus, 115g of shepherd's purse, 115g of chicken vine, 192g of forsythia, 90g of loquat leaves, 39g of cicada slough, and 90g of gallinaceous gold. Soak in water, decoct twice, the first time for 1.5 hours, the second time for 1 hour, combine the decoction, filter, and concentrate the filtrate to a clear paste with a relative density of 1.03-1.06 (55-65°C), add honey, sweet element, potassium sorbate, add water to the specified amount, stir well, filter, fill, sterilize, and make oral liquid 1000ml.

[0016] [Identification] (1) Take 30ml of this product, shake and extract 3 times with n-butanol saturated with water, 15ml each time, combine the n-butanol solution, wash with 30ml of n-butanol-saturated water, separate the n-butanol solution, Evaporate to dryness, add methanol 2ml to dissolve the residue, pass the solution through a neutral alumina ...

Embodiment 2

[0029] Embodiment 2: Determination of the content of Hawthorn Neijin Capsules

[0030] Take 1090g of hawthorn, 705g of Tibetan calamus, 575g of shepherd's purse, 575g of chicken vine, 960g of forsythia, 450g of loquat leaves, 195g of cicada slough, and 450g of gallinaceous gold. Combine the decoction for 1 hour, filter, concentrate the filtrate to a thick paste with a relative density of 1.20-1.22 (60°C), dry it, grind it into powder, add starch, mix well, make granules, dry it, add talcum powder, Magnesium stearate, mixed evenly, packed into capsules, made into 1000 capsules.

[0031] [Identification] (1) Take 2g of the content of this product, add 30ml of water, soak in a 60°C water bath for 30 minutes, centrifuge, take the supernatant and transfer it to a separatory funnel, shake and extract 3 times with n-butanol saturated with water, 15ml each time, combine the n-butanol solution, wash with 30ml of n-butanol-saturated water, separate the n-butanol solution, evaporate to ...

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PUM

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Abstract

The invention relates to a content measuring method of a Chinese patent drug. The steps of the invention are that the chromatographic condition and the systematical employment and suitability test are the first step. The preparation of the solution for comparison is the second step of the invention. 3. After extracting by methyl alcohol, the extract solution of the preparation specimen is concentrated to the low alcoholic solution or the alcoholic-free solution. 4. After the purge process 3, the concentration solution of the extract solution is transferred to the macroreticular resin of a neutral alumina pole, wherein the lower portion is neutral alumina, and the upper portion is pre-treated macroreticular resin. The upper portion and the lower portion are washed by water and a grain alcohol solution of 10-25% sequentially, then the pole is eluted by the grain alcohol solution of 50-95%, and the eluent is collected and evaporated to dryness, further the residue is dissolved and has the constant volume and the filtration. The sequent filtration solution is achieved as the specimen solution. 5. According to the measuration, the solution for comparison of 10 mul and the specimen solution of 20 mul are precisely extracted separately, and the liquid chromatograph is injected, after measuring, the aim is achieved.

Description

technical field [0001] The invention relates to a content determination method of a Chinese patent medicine. Background technique [0002] Chinese Patent Application No. 200410034161.9 discloses "a medicine for invigorating spleen and stomach, eliminating stagnation and stagnation". , A pharmaceutical composition with the effect of improving intelligence and calming the nerves. The medicament is made of the raw materials with the following weight proportions: hawthorn 100-1500, Tibetan calamus 80-1300, shepherd's purse 50-1100, chicken vine 50-1100, forsythia 90-1500, loquat leaves 50-800, cicada slough 10 -250, chicken gold 50-800. It can treat gastritis caused by weak spleen and stomach, indigestion, bad breath, abdominal distension, weight loss, restlessness, insomnia, dreaminess, forgetfulness and other diseases. The invention discloses the composition, preparation method and pharmacodynamic data of the above pharmaceutical preparations, but how to accurately measure ...

Claims

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Application Information

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IPC IPC(8): A61K36/888A61K9/48A61P1/14G01N30/02G01N30/90A61K35/38A61K35/57A61K35/64
Inventor 杨增明
Owner 云南神威施普瑞药业有限公司
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