Method for preparing temperature sensitive sustained-release gel of chitosan fat complexes
A temperature-sensitive hydrogel, chitosan technology, applied in the directions of pharmaceutical formulations, drug delivery, etc., can solve problems such as staying, and achieve the effects of simple operation, improved sensitivity, and good economic development potential.
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[0013] Example 1
[0014] Add chitosan (0.36g) to acetic acid buffer (0.1M, pH 3.8, 18ml), stir well, add 5mg of doxorubicin, stir to dissolve (3000rpm), place in an ice bath and continue to stir for 15min, the αβ- Sodium glycerophosphate (40%, 3ml) was cooled in a refrigerator at 4°C for 15 minutes, and then the chitosan solution was slowly added under stirring (3000 rpm), and stirring was continued for 15 minutes to obtain a chitosan temperature-sensitive doxorubicin sustained-release gel.
Example Embodiment
[0015] Example 2
[0016] Add chitosan oleate lipid complex (0.18g) into acetate buffer (0.15M, pH 4.2, 18ml), stir well, add 2mg of doxorubicin, stir to dissolve (4000rpm), place in an ice bath and continue stirring For 20 minutes, cool αβ-sodium glycerophosphate (45%, 3ml) in a refrigerator at 4°C for 20 minutes, then slowly add the chitosan oleate solution under stirring (4000rpm), and continue stirring for 20 minutes to obtain chitosan oleate Temperature sensitive doxorubicin sustained-release gel.
Example Embodiment
[0017] Example 3
[0018] Add chitosan linoleic acid ester complex (0.36g) into acetic acid buffer (0.2M, pH 4.6, 18ml), stir well, add 5mg paclitaxel, stir to dissolve (3500rpm), place in an ice bath and continue stirring for 30min , Cool the sodium αβ-glycerophosphate (50%, 2ml) in an ice bath for 30 minutes, then slowly add the chitosan linoleate solution under stirring (3500 rpm), and continue stirring for 30 minutes to obtain chitosan linoleate Temperature sensitive paclitaxel sustained-release gel.
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