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Method for preparing lutein water-soluble dry powder

A lutein and water-soluble technology is applied in the field of preparation of food-grade lutein water-soluble dry powder, which can solve the problems of lutein crystal embedding protection, difficult operation, and high requirements for operating conditions, and achieve physical stability and Good chemical stability, good coloring and nutritional enhancement, and the effect of increasing the content of all-trans

Active Publication Date: 2010-04-14
ZHE JIANG MEDICINE CO LTD XINCHANG PHARMA FAB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Transient high-temperature and high-pressure equipment is used in this process, which is difficult to operate in production, and the solvent used has a high boiling point, resulting in only 50% of the all-trans isomer content of the active compound in the lutein water dispersion system in the final product, which affects product biological activity
[0006] CN1,125,145C relates to a preparation method of lutein stable water dispersion and stable water-dispersible dry powder, the protective colloid used in the method is sodium caseinate or casein, but as CN1,101,425C As mentioned in , a solvent with a higher boiling point such as isopropanol is used in the process, and the maximum temperature of the process reaches 240 ° C, resulting in the content of all-trans isomers of the active ingredients in the final product being about 50%, which is very important for the leaf It is far from enough to increase the biological activity of flavins when they are used in food additives or food fortification or drugs, and high-pressure equipment is used in the process
[0007] In short, the preparation methods of lutein water-soluble preparations disclosed by the above-mentioned known technologies require relatively high operating conditions, and industrial production is difficult; the lutein crystals are not well embedded and protected, and the stability of the product is not good. ; The content of the all-trans isomer of the active ingredient in the final product is low, generally around 50%, with an amorphous structure, which affects the coloring effect or bioavailability of the product

Method used

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  • Method for preparing lutein water-soluble dry powder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Fully mix 30g of lutein crystals and 650g of acetone in a 1000ml three-necked bottle, then add 6.0g of mixed tocopherols and 3.0g of sorbitan fatty acid ester, mix well, heat the mixture to 60°C and dissolve it for 0.5hr. Get an oily phase. 75.0 g of modified starch and 136.0 g of glucose were dissolved in 600 ml of deionized water at 80° C. for 0.5 hr, then cooled down to 40° C. for use.

[0030] Under high-speed shearing, the oil phase is slowly added to the water phase to mix and emulsify, and then the emulsion is uniformly passed through a high-pressure homogenizer, the pressure used is 45MPa, and the homogenization is performed twice to make the final emulsion particle size reach about 250nm. The organic solvent acetone and part of the water are evaporated under reduced pressure, so that the solid content in the final emulsion is about 40%, and most of the remaining water is removed by spray drying, and the emulsion is turned into dry powder particles.

[0031] Fi...

Embodiment 2

[0033] Fully mix 18kg of lutein crystals and 450kg of ethyl acetate in a reaction kettle, then add 10kg of mixed tocopherols, 5.0kg of ascorbyl palmitate, and 8.0kg of sunflower oil, mix well and stir to dissolve at 80°C for 0.5hr. A clear, transparent solution was formed as an oily phase. Disperse 75.0kg of modified starch in 200kg of water, add 120.0kg of sucrose, dissolve completely at 80°C after mixing, cool to 45°C, and use it as the water phase for later use.

[0034] Under the condition of high-speed shearing, the oil phase is slowly added to the water phase to mix and emulsify, and then the emulsion is homogenized through a high-pressure homogenizer, the pressure used is 60MPa, and the homogenization is performed twice to make the final emulsion particle size reach about 170nm. The organic solvent ethyl acetate and part of deionized water are removed under reduced pressure, so that the solid content in the final emulsion is about 55%, and the emulsion is turned into mi...

Embodiment 6

[0042] Application of Lutein Dry Powder in Orange Juice Beverage

[0043] (1) Orange Juice Drink Recipe

[0044] Element

Amount added (g)

concentrated orange juice

20

White sugar

80

High Ester Pectin

0.5

citric acid

1.5

Sodium iso-Vc

0.4

Lutein dry powder

0.2

water

add up to 1000

[0045] (2) Technological process: dissolve the ingredients, mix them evenly; The amount of lutein added: 10mg / kg. The amount of lutein added during production can be appropriately increased or decreased according to nutritional fortification and coloring chromaticity requirements.

[0046] (3) Physical stability and chemical stability of orange juice beverage

[0047] The physical stability and chemical stability of the orange juice beverage added with lutein are shown in Table 2 and Table 3, respectively.

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Abstract

The invention discloses a preparation method of a food grade phylloxanthin water-soluble dry powder. The content of the all-trans isomer of the active ingredient of the product obtained by means of the prior method is low with an amorphous structure, so that the coloring effect or bioavailability of the product is affected. The procedures of the invention are as follows: when a phylloxanthin crystal is mixed with a low boiling point and volatile organic solvent which has a big solubility to the phylloxanthin crystal, and then the mixer is heated and dissolved so as to get an oil phase; a modified starch is mixed with water, and the mixer is warmed up and dissolved, then is cooled so as to get a water phase; the oil phase is slowly added into the water phase after mixed around, so that an emulsive mixed liquor is gotten; the emulsive mixed liquor is uniform through a high-pressure uniform machine, thereby the latex grain diameter can reach the nanometer level; the organic solvent in thelatex system can be removed by a conventional separation method; the normal water in the latex can be removed to get the dry powder by a spray drying process or spray starch fluidized bed drying process. The invention can greatly improve the all-trans content of the active ingredient of the termination product in amorphous form, thereby the invention has the advantages of good coloring and nutrition strengthening effects.

Description

technical field [0001] The invention relates to an edible natural pigment, in particular to a method for preparing food-grade water-soluble dry powder of lutein extracted from marigolds. Background technique [0002] Lutein, also known as "plant lutein", is a natural pigment widely found in vegetables, flowers, fruits and some organisms. It belongs to carotenoids, and its molecular formula is C 40 h 56 o 2 , with a molecular weight of 568.85, is a natural antioxidant, colorant and nutritional supplement with excellent performance. Modern medical research has confirmed that a certain amount of lutein can resist cell and organ aging caused by free radicals, thereby preventing diseases such as cardiovascular disease, tumors, vision loss and blindness caused by organ aging. In addition, in recent years, it has also been confirmed that lutein is related to the "age-induced macular degeneration (ARMD)" disease in humans. Lutein and its isomer zeaxanthin are the only two caroten...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C09B61/00A23L1/275
Inventor 周迪许新德张莉华叶双明丁驰宇陈伯秋邵斌
Owner ZHE JIANG MEDICINE CO LTD XINCHANG PHARMA FAB
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