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Pharmaceutical composition taking metformin hydrochloride and vigelegting as active component as well as preparing method and uses thereof

A technology of metformin hydrochloride and active ingredients, applied in the field of medicine, can solve the problems of insulin deficiency, discount of insulin effect, no compound metformin hydrochloride and vildagliptin related literature and patent reports, etc.

Inactive Publication Date: 2008-05-21
BEIJING RUNDEKANG MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The ability to produce insulin in patients with type 2 diabetes is not completely lost. Some patients even produce too much insulin in their bodies, but the effect of insulin is greatly reduced. Therefore, insulin in patients is a relatively deficient
[0008] Through the search, there are no relevant literature and patent reports on compound metformin hydrochloride and vildagliptin

Method used

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  • Pharmaceutical composition taking metformin hydrochloride and vigelegting as active component as well as preparing method and uses thereof
  • Pharmaceutical composition taking metformin hydrochloride and vigelegting as active component as well as preparing method and uses thereof
  • Pharmaceutical composition taking metformin hydrochloride and vigelegting as active component as well as preparing method and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1 metformin hydrochloride and vildagliptin tablet

[0017] prescription:

[0018] components

Dosage

Metformin Hydrochloride

Vildagliptin

microcrystalline cellulose

CMS-Na

Micropowder silica gel

Co-made

1000g

50g

130g

10g

10g

1000 pieces

[0019] Preparation:

[0020] Pass vildagliptin and microcrystalline cellulose through 80-mesh sieve respectively, mix evenly, and mix them with metformin hydrochloride in an equal amount incremental method, stir well to make them even, and set aside; add 50% ethanol solution to the mixed powder, make soft material, granulated with a 24-mesh sieve, dried, granulated with a 20-mesh sieve, added micropowder silica gel and CMS-Na, mixed evenly, and pressed into tablets with a suitable die to obtain the product.

[0021] If the above-mentioned tablet is coated, a coated tablet can be obtained, which can be a film-coate...

Embodiment 2

[0022] Embodiment 2: metformin hydrochloride and vildagliptin capsules

[0023] prescription:

[0024] components

Dosage

Metformin Hydrochloride

Vildagliptin

Magnesium stearate

500g

50g

10g

[0025] Preparation:

[0026] Pass vildagliptin and metformin hydrochloride through an 80-mesh sieve, mix uniformly according to the method of equal volume addition, add magnesium stearate, mix uniformly, pack separately, and obtain the product.

[0027] The used capsule shell can be a common capsule or an enteric-coated capsule.

Embodiment 3

[0028] Example 3: Metformin Hydrochloride and Vildagliptin Chewable Tablets

[0029] prescription:

[0030] components

Dosage

Metformin Hydrochloride

Vildagliptin

xylitol

Mannitol

Sweet Orange Flavor

aspartame

2% PVPk-30 ethanol solution

Magnesium stearate

1000g

100g

500

250

50g

15g

Appropriate amount

15g

[0031] Preparation:

[0032] Vildagliptin, metformin, xylitol, mannitol and other raw and auxiliary materials were passed through 80 mesh sieves respectively, mixed uniformly by the method of equal increase, and 2% PVP-k30 ethanol solution was added to make soft materials, granulated with 16 mesh sieves, Dried, sieved with a 20-mesh sieve, added other flavoring agents, sweeteners, and glidants, mixed evenly, and pressed into tablets.

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PUM

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Abstract

The invention relates to a pharmaceutical composition which takes metformin hydrochloride and vildagliptin as the active ingredients and the preparation method and usage thereof. The invention takes metformin hydrochloride and vildagliptin as the pharmaceutical active ingredients and mixed with pharmaceutically acceptable excipients to form the pharmaceutical composition. The invention can be used for diet control and the treatment of type 2 diabetes can not be controlled appropriately by movements, and the invention can also be used in the type 2 diabetes which can not be controlled by the single administration of metformin hydrochloride or vildagliptin. The contents of the invention take metformin hydrochloride and vildagliptin as the raw materials and are added with given type and proportion of excipients, then the invention is prepared and developed into tablets, capsules, granules, dispersion tablets, chew tablets, buccal tablets, effervescent tablets, effervescent granules and other various oral preparations according to the technical means illustrated by the invention.

Description

technical field [0001] The invention relates to a pharmaceutical composition with metformin hydrochloride and vildagliptin as active components, a preparation method and application thereof, and belongs to the technical field of medicine. Background technique [0002] Diabetes mellitus (Diabetes mellitus) is a syndrome of glucose, protein and lipid metabolism disorders caused by insulin deficiency or insulin cell metabolism defects. Proper control can lead to chronic complications in tissues and organs such as eyes, kidneys, nerves, blood vessels, and heart, and eventually lead to blindness, lower limb gangrene, uremia, cerebral apoplexy or myocardial infarction, and even life-threatening. Diabetes is a common disease. With the improvement of living standards, the incidence of diabetes is increasing year by year. The prevalence of diabetes in developed countries has reached 5% to 10%, and the prevalence in my country has reached 3%. [0003] Type 2 diabetes, also known as ...

Claims

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Application Information

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IPC IPC(8): A61K31/40A61K9/16A61K9/20A61K9/46A61K9/48A61P3/10A61K31/155
Inventor 陈瑞晶
Owner BEIJING RUNDEKANG MEDICAL TECH CO LTD
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