RA preventing and curing for piglet yellow scour, preparation and application thereof

Abstract

The invention relate to a receptor blocker for preventing and treating the yellow diarrhea of the piggy and the preparation and application thereof. The invention is a beat blocker assembled with recombinant technology of the bacterial chromosome DNA giant molecule, the combining and testing technology of the pathogenicbacteria receptor and the adhesion, the receptor enclosing / blocking technology of the adhesion, the vitro express technology of the adhesion operon, the receptor blocker is able to be planted, settled down, proliferated after the beat blocker is taken by the piggy , and presented 987P and K88 adhesion on the surface of the enteric canal epidermal cell, the combining target position point of the enteric canal epidermal cell and the ETEC pathogenicbacteria of the mediated 987P and K88 adhesion is solved through combining the receptor blocker with the enteric canal epidermal cell. The default of drug resistance, the normal flora disturbance of the animal gastrointestinal tract, dyspepsia, abwehrkraft des koepers decreasing, etc. caused by the using of compound antibiotic is solved. The invention has the advantages of preventing the external pathogenicbacteria from entering into the body of the animal, and directly enclosing the combination of the target position point of the piggy enteric canal epidermal cell and the enterotoxigenic colon bacillus mediated pathogenicbacteria of the 987P and K88 adhesion.

Description

technical field [0001] The invention relates to a biological agent-receptor blocker, in particular to a receptor blocker for preventing and treating piglet yellow scour and its application. Background technique [0002] Before the present invention, mainly adopt antibiotic or (and) enterotoxigenic escherichia coli (ETEC) K88 and K99 bivalent genetic engineering vaccine for prevention and clinical treatment for the prevention and treatment of piglet yellow scour, reduce to a certain extent The diarrhea rate of newborn piglets and weaned piglets, but the long-term and large-scale use of compound antibiotics leads to the continuous generation and horizontal spread of multi-drug resistant ETEC, and causes the inefficiency of antibiotics and accumulation in animals, which can also cause gastrointestinal Disturbance of the normal flora of the intestinal tract, indigestion, leading to a decrease in the resistance of the gastrointestinal tract and the body, prone to secondary or con...

AI Technical Summary

Problems solved by technology

[0002] Before the present invention, mainly adopt antibiotic or (and) enterotoxigenic escherichia coli (ETEC) K88 and K99 bivalent genetic engineering vaccine for prevention and clinical treatment for the prevention and treatment of piglet yellow scour, reduce to a certain extent The diarrhea rate of newborn piglets and weaned piglets, but the long-term and large-scale use of compound antibiotics leads to the continuous generation and horizontal spread of multi-drug resistant ETEC, and causes the inefficiency of antibiotics and accumulation in animals, which can also cause gastrointestinal Disturbance of the normal flora of the intestinal tract, indigestion, leading to a decrease in the resistance of the gastrointestinal tract and the body, prone to secondary or concurrent multiple diseases; K88 and K99 bivalent genetic engineering vaccines are only limited to the use of immunized pregnant sows to produce maternal antibodies After eating colostrum with high maternal antibody content, passive immunity will be generated within a certain period of time, which can resist and neutralize the ETEC pathogenic bacteria that have invaded and infected the body, and protect piglets from disease, but the immunity period is short and long-term use , under the selection of immune pressure, the pathogenic strains of dominant serotypes are continuously increasing, and the original vaccines have poor immunity against infection by such pathogenic strains

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