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Medical use of baicalin and scutellarein derivatives

A technology of baicalin and baicalein, applied in the field of baicalin, can solve the problems of unclear biochemical mechanism, not very good, and lack of effectiveness of drugs, so as to increase energy metabolism of the body, promote glucose absorption and fat oxidation, and reduce insulin resistance Effect

Inactive Publication Date: 2008-07-02
SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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  • Abstract
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Problems solved by technology

[0003] (2) So far, there is no good treatment for obesity and metabolic syndrome. Usually, hypoglycemic drugs, lipid-lowering drugs and antihypertensive drugs are used to treat metabolic syndrome, but these drugs lack effectiveness
AMPK is currently the only confirmed target enzyme of biguanide drugs, but the biochemical mechanism of its activation of AMPK is still unclear

Method used

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  • Medical use of baicalin and scutellarein derivatives
  • Medical use of baicalin and scutellarein derivatives
  • Medical use of baicalin and scutellarein derivatives

Examples

Experimental program
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Effect test

Embodiment Construction

[0052] Pharmacological Tests:

[0053] 1. In vitro experiment

[0054] 1. Materials and Reagents

[0055] Human liver cancer HepG2 cells were purchased from the Cell Resource Center, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences. MEM medium dry powder, 0.25% trypsin-EDTA, fetal bovine serum, 100× sodium pyruvate, and 100× penicillin and streptomycin were purchased from Invitrogen. Protein quantification kit was purchased from Bio-Rad. Anti-AMPKα2, phosphorylated AMPKα (p-AMPKα), ACC and phosphorylated ACC (p-ACC) antibodies were purchased from Cell signaling company. β-actin primary antibody was purchased from Lab Vision Company. Horseradish peroxidase-labeled secondary antibodies were purchased from Jackson. Protease inhibitor complex was purchased from Calbiochem. All other reagents were analytically pure.

[0056] 2. Cell culture

[0057] Human liver cancer cells HepG2 were cultured in MEM medium containing 10% fetal bovine serum, 100 U / ml...

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Abstract

The invention discloses a baicalein derivative drug which can be used for the prevention and treatment of metabolic syndrome, obesity, type 2 diabetes and atherosclerotic cardiovascular disease. The baicalein derivative can increase the metabolic activity for the prevention and treatment of metabolic syndrome, obesity, type 2 diabetes and atherosclerotic cardiovascular disease by controlling and activating the activity of single adenylate activated protein kinase.

Description

technical field [0001] The present invention relates to the medical use of baicalin and baicalein derivatives, and more specifically refers to the prevention and treatment of baicalin and the baicalein derivatives by regulating and activating the activity of monoadenylate-activated protein kinase in tissues and increasing metabolic activities Metabolic syndrome, obesity, type 2 diabetes and atherosclerotic cardiovascular and cerebrovascular diseases. Background technique [0002] (1) Metabolic syndrome is a group of complex metabolic disorders, including the aggregation of risk factors such as obesity, hypertension, hyperglycemia, dyslipidemia, and insulin resistance. Metabolic syndrome is a high-risk factor for type 2 diabetes and cardiovascular disease, and has become an urgent problem in the world of medicine. [0003] (2) So far, there is no good treatment for obesity and metabolic syndrome. Usually, hypoglycemic drugs, lipid-lowering drugs and antihypertensive drugs ar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K31/352A61P3/06A61P3/10A61P13/12A61P17/00A61P27/02
Inventor 彭红丽沈竞康刘代华郭虹霞马兰萍熊兵张莉
Owner SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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