Cleaning fermentation technique for neomycin

Abstract

The invention provides a clean fermentation process of neomycin, which uses Streptomyces fradiae as producing stain and modifies the composition of sugar supplementing solution, the supplementing rate control and other parameters during fermentation process based on the conventional neomycin microbial fermentation production process. The inventive process is scientific and reasonable, and can improve the concentration of the fermentation product and reduce residual sugar content. The starch consumption of unit neomycin production is remarkably reduced, and the emitted COD pollution load is reduced by approximate 50%, so as to achieve clean production purpose.

Description

technical field [0001] The invention belongs to the field of biotechnology, and more specifically relates to a clean fermentation process of neomycin. Background technique [0002] In recent years, neomycin has been widely used as a feed additive. Due to the large amount of feed additives used at home and abroad and a wide range of applications, it has shown a good prospect. In recent years, the demand for neomycin in domestic and foreign markets has a trend of substantial growth. The development of neomycin and the improvement of production level have broad market prospects and significant economic benefits. At present, the fermentation level (120-hour period) of neomycin produced by domestic enterprises is about 8000 units / mL, and the extraction rate is about 70%; the fermentation level (120-hour period) of foreign neomycin can reach 11000 units / mL, and the extraction rate reaches About 85%. This shows that the domestic production of neomycin still has a certain distan...

AI Technical Summary

Problems solved by technology

Blindly adding a large amount of starch hydrolyzed sugar solution, resulting in the process of multiple bacterial proliferation during the product synthesis period, which reduces the product synthesis rate

At the same time, because microorganisms cannot use polysaccharides, a large amount of polysaccharides that cannot be used by microorganisms accumulate in the bioreactor, and this part of polysaccharides is discharged with wastewater, causing environmental pollution and waste of resources.

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