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Liquid phase chip used for detecting bone metabolism biochemical marker and its preparing method

A liquid phase chip and marker technology, applied in the field of medicine and biology, to achieve the effect of simple preparation method, predicting the degree of fracture risk, and maintaining the natural conformation

Inactive Publication Date: 2008-07-16
SUREXAM BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these methods can only obtain the concentration of one marker per test

Method used

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  • Liquid phase chip used for detecting bone metabolism biochemical marker and its preparing method
  • Liquid phase chip used for detecting bone metabolism biochemical marker and its preparing method
  • Liquid phase chip used for detecting bone metabolism biochemical marker and its preparing method

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Embodiment 1

[0066] The capture antibody of the present invention is respectively capable of binding to bone alkaline phosphatase (BALP), osteocalcin (BGP), type I procollagen N-terminal propeptide (PINP), type I procollagen C-terminal propeptide ( PICP), plasma tartrate-resistant acid phosphatase (TRAP5b), type I collagen cross-linked C-telopeptide (CTX), urinary collagen pyridinoline (PYD), urinary collagen deoxypyridinoline (DPYD), and type I collagen cross-linked N- Telopeptide (NTX) specific binding monoclonal antibody; The detection antibody is respectively able to bone alkaline phosphatase (BALP), osteocalcin (BGP), type I procollagen N-terminal propeptide (PINP) , type I procollagen C-terminal propeptide (PICP), plasma tartrate-resistant acid phosphatase (TRAP5b), type I collagen cross-linked C-telopeptide (CTX), urinary collagen pyridinoline (PYD), urinary collagen deoxypyridinoline (DPYD) and type I collagen cross-linked N-terminal peptide (NTX) specific binding monoclonal or pol...

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PUM

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Abstract

The invention discloses a liquid phase chip kit which is used for the parallel detection of a plurality of bone metabolism biochemical markers, and the invention mainly includes: coated microspheres, detection antibodies which are respectively labelled by biotin and streptavidin phycoerythrin. The liquid phase chip kit which is used for the parallel detection of a plurality of bone metabolism biochemical markers and is provided by the invention has the advantages of high detection efficiency, fewer required samples, strong specificity, high sensitivity, and so on. At the same time, all the bone metabolism biochemical markers can be combined freely, and the usage is convenient. At the same time, as all the reactions are positioned in the liquid phase environment, the invention is more conductive to the maintenance of the native conformation of protein, the reaction of a probe and the object to be detected is faster and more complete, while the detection sensitivity and the linear range are both greatly improved.

Description

technical field [0001] The invention belongs to the category of medical biology, and in particular relates to a liquid phase chip for parallel detection of multiple bone metabolism biochemical markers and a preparation method thereof. Background technique [0002] Osteoporosis (OP) is a metabolic disease that is prone to fractures due to decreased bone mass and microstructural destruction of bone tissue leading to increased bone fragility. Osteoporosis has become the seventh most common and frequently-occurring disease. The overall prevalence rate in mainland China is 12.4%, and more than half of the elderly population suffers from it. Among them, the incidence of fractures is close to one-third . According to the data of the 2006 Global Osteoporosis Academic Conference: Osteoporosis has reached the extent of spreading in China. In the past 30 years, the number of osteoporosis patients in China has increased by 300%, and the medical expenses caused by 88 million patients ea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/543G01N33/532
Inventor 许嘉森林一群
Owner SUREXAM BIO TECH
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