Timely released preparation and preparation thereof
A technology of timed release and preparation, which is applied in the direction of pill delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc. It can solve the problems of difficulty in making soft materials, short time lag, etc., achieve good pulse effect, reduce viscosity, and prevent rapid release effect
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Embodiment 1
[0021] Tablet core prescription (total amount is 100mg):
[0022] %(W / W)
[0023] Isosorbide mononitrate 20
[0024] Microcrystalline Cellulose 20
[0025] Starch 46.2
[0026] Crospovidone 10
[0027] Povidone 2.8
[0028] Talc powder 1
[0029] Total 100
[0030] After mixing the above-mentioned first 4 ingredients, add 28 μl of 75% ethanol aqueous solution containing 10wt% povidone to make a soft material, sieve it, put it into an oven to dry at 50°C for 1 hour, add 1wt% talcum powder and mix for 3 minutes, Compressed into tablet cores.
[0031] Coating prescription (300mg in total):
[0032] %(W / W)
[0033] Hydroxypropyl Methyl Cellulose K100M 10
[0034] Acrylic resin RL 31.5
[0035] Povidone K30 18
[0036] Microcrystalline Cellulose 15
[0037] Lactose 22.5
[0038] Sodium stearate 2
[0039] Talc powder 1
[0040] Total 100
[0041] After uniformly mixing the first six auxiliary materials, granulate with 70...
Embodiment 2
[0043] Tablet core prescription (total amount is 100mg):
[0044] %(W / W)
[0045] Nitrindipine 10
[0046] Lactose 39.2
[0047] Mannitol 15
[0048] Sodium carboxymethyl starch 8
[0049] Microcrystalline Cellulose 25
[0050] Hydroxypropyl methylcellulose 1.8
[0051] Talc powder 1
[0052] Total 100
[0053] After mixing the aforementioned 5 ingredients, add 60 μl of 50% ethanol aqueous solution containing 3% hydroxypropyl methylcellulose to make a soft material, sieve it, dry it at 50°C for 1 hour, add 1 wt% talcum powder and mix for 3 minutes , pressed into tablet cores.
[0054] Coating prescription (300mg in total): % (W / W)
[0055] Hydroxypropyl Methyl Cellulose K15M 10
[0056] Povidone K30 18
[0057] Ethyl cellulose (0.01Pa.s) 30
[0058] Microcrystalline Cellulose 15
[0059] starch 23
[0060] Magnesium stearate 3
[0061] Talc powder 1
[0062] Total 100
[0063] After uniformly mixing the first six auxiliary materials, gran...
Embodiment 3
[0065] Tablet core prescription (total amount is 100mg):
[0066] %(W / W)
[0067] Salbutamol Sulfate 8
[0068] Starch 73.4
[0069] Sodium Carboxymethyl Cellulose 15
[0070] Povidone 2.6
[0071] Talc powder 1
[0072] Total 100
[0073] After mixing the above three ingredients, add 26 μl of 75% ethanol aqueous solution containing 10% povidone to make a soft material, sieve, dry at 50°C for 1 hour, add 1wt% talcum powder and mix for 3 minutes, and press into Chips.
[0074] Coating prescription (300mg in total): % (W / W)
[0075] Hydroxyethylcellulose (Natrosol HX) 6
[0076] Povidone K30 25
[0077] Ethyl cellulose (0.01Pa.s) 30
[0078] Microcrystalline Cellulose 12
[0079] Compressible starch 22
[0080] Zinc stearate 4
[0081] Talc powder 1
[0082] Total 100
[0083] After uniformly mixing the first six auxiliary materials, granulate with 70% ethanol aqueous solution, dry, granulate, and then mix with 1wt% talcum powder for 3 minu...
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