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Temperature sensing medicine carrying micelle with magnetothermal effect, preparation method and method of use thereof

A technology of drug-loaded micelles and magnetocaloric effect, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc. It can solve the problems of no cancer drugs and poor biocompatibility

Inactive Publication Date: 2008-08-20
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing manganese-zinc-ferrite materials for hyperthermia are generally used alone without the cooperation of relevant cancer treatment drugs; at the same time, because there is no polymer material package, the biocompatibility is poor

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Using benzoyl peroxide (BPO) as initiator and 2-mercaptoethanol as chain transfer agent, poly(N-isopropylacrylamide) (PNIPAAm) prepolymers containing terminal hydroxyl groups were synthesized. Then, the prepolymer containing terminal hydroxyl group was used as macromolecular initiator, and Sn(Oct)2 was used as catalyst to initiate ring-opening polymerization of lactide to obtain PNIPAAm-PLA block copolymer.

[0022] According to chemical composition: x=0.1 Weigh raw material: MnSO 4 ·H 2 O, ZnSO 4 ·7H 2 O, FeSO 4 ·7H 2 O, with NaOH as the precipitant, according to n(M):n(OH - )=1:214 (M represents all metal ions) Weigh the required amount of NaOH, and prepare a solution with a concentration of 10 mg / ml, first mix the three sulfates and grind them into powder in a high-speed grinding cup, then add NaOH solution, stirring repeatedly to make it into a paste. After standing for 12 hours, it was dried at 80°C. After it was completely dried, it was re-ground and roasted...

Embodiment 2

[0026] Polyisopropylacrylamide (PNIPAAm) was synthesized with benzoyl peroxide (BPO) as initiator and 2-mercaptoethanol as chain transfer agent.

[0027] According to the chemical composition: x=0.3 Weigh the raw material: MnSO 4 ·H 2 O, ZnSO 4 ·7H 2 O, FeSO 4 ·7H 2 O, with NaOH as the precipitant, according to n(M):n(OH - )=1:214 (M represents all metal ions) Weigh the required amount of NaOH, and prepare a solution with a concentration of 20 mg / ml, first mix the three sulfates and grind them into powder in a high-speed grinding cup, then add NaOH solution, stirring repeatedly to make it into a paste. After standing for 12 hours, it was dried at 80°C. After it was completely dried, it was re-ground and roasted at 400°C for 1 hour in a muffle furnace. After natural cooling, it was washed with hot distilled water and filtered. To remove soluble sulfate, use BaCl 2 After detecting that there is no sulfate ion in the filtrate, rinse it once with absolute ethanol, and dry i...

Embodiment 3

[0031]The ring-opening polymerization was initiated by lactide and PEG to obtain the block copolymer PLA-PEG.

[0032] According to chemical composition: x=0.1 Weigh raw material: MnSO 4 ·H 2 O, ZnSO 4 ·7H 2 O, FeSO 4 ·7H 2 O, with NaOH as the precipitant, according to n(M):n(OH - )=1:214 (M represents all metal ions) Weigh the required amount of NaOH, and prepare a solution with a concentration of 10 mg / ml, first mix the three sulfates and grind them into powder in a high-speed grinding cup, then add NaOH solution, stirring repeatedly to make it into a paste. After standing for 12 hours, it was dried at 80°C. After it was completely dried, it was re-ground and roasted at 400°C for 1 hour in a muffle furnace. After natural cooling, it was washed with hot distilled water and filtered. To remove soluble sulfate, use BaCl 2 After detecting that there is no sulfate ion in the filtrate, rinse it once with absolute ethanol, and dry it at 60° C. to obtain manganese-zinc ferrit...

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Abstract

The invention relates to the preparation and application method of a temperature sensitive micelle with magnetocaloric effect, belonging to the field of drug carrier in biological medicine, which adopts the technical proposal that: a quantity of temperature sensitive polymer is dissolved into an organic solvent; then the organic solvent together with drugs and Mn-Zn ferrite nanometer particles undergoes dialysis process in a great amount of deionized water to get a temperature sensitive micelle with magnetocaloric effect; and finally after certain biological treatment, the micelle is injected into human body; which is characterized in that an outside magnetic field locates the drug carrier near the tumor site; at the same time an alternating magnetic field raises the temperature of the micelle to reach the lowest critical temperature, so that the drug is released at the shrinking of the micelle. The method has an advantage that a new type of bio-control sustained release carrier is provided for the field of biological medicine.

Description

technical field [0001] The invention belongs to the technical field of drug carriers in biomedicine, and particularly relates to a temperature-sensitive drug-loaded micelle with magnetocaloric effect, a preparation method and a use method thereof. Background technique [0002] Cancer is one of the main diseases that endanger human life and health. In order to conquer this stubborn disease, people have researched and tried many kinds of treatment methods, including surgical resection, chemotherapy, radiotherapy, hyperthermia and starvation therapy. However, for now, various treatments are not very effective due to the limitations and side effects of certain treatments that cannot be avoided. Among them, heat therapy has achieved some results after years of development, from the initial heat treatment of the outside to the heat treatment of the interior. In recent years, researches on magnetic mediahyperthermia using material magnetocaloric effect heating have been started at...

Claims

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Application Information

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IPC IPC(8): A61K47/34A61K47/32A61K47/02A61K35/00
Inventor 任杰贾梦虹谭庆刚任天斌
Owner TONGJI UNIV
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