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Ambroxol hydrochloride sustained-release dropping pill and preparation method thereof

A technology of ambroxol hydrochloride and sustained-release dripping pills, which is applied in the direction of medical formulas, medical preparations with no active ingredients, medical preparations containing active ingredients, etc., which can solve the problems of inconvenient swallowing by children, low bioavailability, There are problems such as the first-pass effect, and the effect of avoiding the first-pass effect of the liver and intestines, high bioavailability, and improving bioavailability

Inactive Publication Date: 2008-09-24
北京博智绿洲医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

In view of the inconvenient use of ambroxol hydrochloride injection, which can cause mild nausea, pain at the injection site and allergic reactions when administered, the oral absorption of tablets and capsules is slow, there is a first-pass effect, low bioavailability, and it is not convenient for children to swallow and the disadvantages of reducing dosage for the elderly, making it into sustained-release drop pills

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0030] Provide a group of specific examples below, use hydrophilic framework material and hydrophobic framework material respectively as mixed matrix and the preparation method to ambroxol hydrochloride slow-release dripping pill is further explained:

[0031]Single matrix experiments:

[0032] Example 1 is based on total weight 100g, PEG4000 70%, glyceryl monostearate 20%, ambroxol hydrochloride 10%, after matrix is ​​heated and melted in a water bath, add ambroxol hydrochloride, fully stir, make it mix, Under the condition of 80°C heat preservation, drop the material liquid into the condensation column filled with dimethyl silicone oil. The temperature of the upper part of the condensate is 40°C, and the temperature of the bottom is 0°C. After forming, take it out, and use absorbent paper to absorb the adhesion on the surface. Dimethicone oil, dried under natural conditions, that is.

[0033] The obtained product has a cumulative release percentage of 55-79% in 2 hours, a c...

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PUM

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Abstract

The invention relates to a sustained-release drug used for treating bronchitis, asthma and lung diseases as well as the preparation method thereof, and aims to supplement the deficiencies that existing tablets, capsules and oral formulations have short acting time, unsteady plasma concentration and deficient preparation method and provide a sustained-release ambroxol hydrochloride dropping pill which has good substance dispersion state, long acting time and high bioavailability. The sustained-release ambroxol hydrochloride dropping pill is prepared by adopting ambroxol hydrochloride as the ingredient, adding in hydrophilic frame ingredients and hydrophobic frame ingredients as the stroma according to a definite proportion and mixing well, heating the mixture to meltdown and mixing well, putting the melted mixture into a dropping pill machine and trickling the melted mixture into a condensing agent to be cooled off.

Description

technical field [0001] The invention relates to a dripping pill preparation with sustained drug release effect for treating bronchitis, asthma and lung diseases and a preparation method thereof. Background technique [0002] Respiratory system disease is a common and frequently-occurring disease that endangers people's health and life, and its incidence rate accounts for the first among many diseases in any age group. According to the data from the Statistical Yearbook of the United States, among all the causes of death, the cause of death related to respiratory diseases (excluding tumors) rose from the 10th in 1970 to the 4th in 1991 (chronic obstructive pulmonary disease) And No. 8 (pneumonia, influenza and its upper respiratory tract infection). The British Society for Thoracic Surgery pointed out in a recent research report that respiratory diseases have replaced cancer and heart disease as the disease with the highest death rate in the UK. Respiratory diseases such as...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K31/137A61K47/34A61P11/00A61K47/10
Inventor 曲韵智
Owner 北京博智绿洲医药科技有限公司
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