Common camellia flavone glycosides A with estrogen liveness, preparation method and application thereof

A technology of camellia flavonoid glycosides and estrogens is applied in the directions of organic active ingredients, medical preparations containing active ingredients, organic chemistry, etc., and can solve the problems of little medicinal value of camellia plants.

Inactive Publication Date: 2008-09-24
DALIAN UNIV
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However, there is little modern resear...

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  • Common camellia flavone glycosides A with estrogen liveness, preparation method and application thereof
  • Common camellia flavone glycosides A with estrogen liveness, preparation method and application thereof
  • Common camellia flavone glycosides A with estrogen liveness, preparation method and application thereof

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Embodiment Construction

[0031] The present invention will be further described below in the form of specific examples. Unless otherwise specified, mass spectrometry (ESI-MS) and nuclear magnetic resonance (NMR) analysis techniques ( 1 H-NMR, 13 C-NMR, H-H COZY, HMBC, HMQC) to analyze the material structure.

[0032] One, the preparation of camellia flavonoid glycoside A

[0033] ①Preparation of ethyl acetate extract of Nanshan tea seed (Camellia semiserrata Chi.) oil meal: heat and reflux extraction with 95% industrial ethanol, solid-liquid ratio 1:10 (g:ml), temperature 95°C, extract 3 times, each time 3 hours; the ethanol extract was concentrated into an extract, suspended with 3 times distilled water, and extracted 3 times with 3 times petroleum ether and 3 times ethyl acetate in sequence according to the volume ratio, to obtain ethyl acetate extract;

[0034] ② Separation of the above-mentioned ethyl acetate extract by silica gel column chromatography, chloroform:methanol 15:1 (volume) mixed s...

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Abstract

The present invention provides camellia flavonoid glycoside A with estrogenic activity, a preparation method and applications thereof. The compound is a novel compound prepared by camellia semiserrata Chi seed oil meal, the system of which is named as kaempferol-3-O-Beta-D-glucosyl-(6.1)-2'', 4''-O-diacetyl-Alpha-L-rhamanopyranosyl-(3.1)-2'', 3'', 4''-O-triacetyl-Alpha-L-rhamnoside. The compound has obvious estrogenic activity.

Description

technical field [0001] The present invention relates to the preparation and application of new components with medicinal activity in natural plants. Background technique [0002] The inventor's research on Camellia plants began in 2002. In the process of joint development of tea oil with Japan Ota Oil Co., Ltd. and Guangxi Bama Wanli Camellia Seed Development Co., Ltd., he successively went to Guangxi and Yunnan, the main producing areas of Camellia plants. , Sichuan and Hunan conducted resource surveys. [0003] The genus Camellia (Camellia Linn.) belongs to the Theaceae family, and there are 280 species in the world, mainly distributed in the tropics and subtropics. There are more than 250 species in my country, mainly produced in southwest to southeast. The Lingnan area is the most distributed, with nearly a hundred species. [0004] Medicinal records include tea fruit (tea seed), bud leaf (tea leaf) and root (tea tree root), camellia seed (tea seed heart), fat oil (te...

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Application Information

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IPC IPC(8): C07H17/07A61K31/7048A61P5/30A61P19/10
Inventor 王永奇唐玲冯宝民史丽颖
Owner DALIAN UNIV
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