Supercharge Your Innovation With Domain-Expert AI Agents!

Sustained release medicinal compositions containing Zaltoprofen, preparation method and application thereof

A sustained-release drug and composition technology, applied in the field of medicine, to achieve the effects of mature production process, guaranteed effectiveness and safety, and convenient use

Inactive Publication Date: 2011-11-09
贾盈
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At home and abroad, there are only literature research reports or product listings of its ordinary tablets

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Sustained release medicinal compositions containing Zaltoprofen, preparation method and application thereof
  • Sustained release medicinal compositions containing Zaltoprofen, preparation method and application thereof
  • Sustained release medicinal compositions containing Zaltoprofen, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Its prescription is:

[0052]

[0053] Preparation Process:

[0054] ① After mixing Zaltobuprofen and lactose evenly, add it into a fluid energy mill for micronization.

[0055] ②Mix the micronized product obtained in ① with other excipients in the prescription evenly, use 10% starch slurry to make soft material, pass through No. and micropowder silica gel, mixed evenly, and compressed into tablets.

Embodiment 2

[0057] Its prescription is:

[0058]

[0059] Preparation process: Weigh the raw and auxiliary materials according to the prescription quantity, mix them evenly, add 10% starch slurry to make soft material, pass the soft material through No. Magnesium and micro-powdered silica gel are mixed and packed into bags.

Embodiment 3

[0061] Its prescription is (making 1000 tablets):

[0062] Extended release partial prescription:

[0063] Zaltobuprofen 90g

[0064] Hydroxypropyl Methyl Cellulose 60g

[0065] Lactose 120g

[0066] Sodium carboxymethyl starch 50g

[0067] Calcium hydrogen phosphate 80g

[0068] 10% starch slurry appropriate amount

[0069] Magnesium Stearate 5g

[0070] Micronized silica gel 2.5g

[0071] Immediate Release Portion Prescription:

[0072] Zaltobuprofen 60g

[0073] Lactose 80g

[0074] Sodium carboxymethyl starch 10g

[0075] 10% starch slurry appropriate amount

[0076] Magnesium Stearate 5g

[0077] Micronized silica gel 2.5g

[0078] Preparation Process

[0079] Sustained release part preparation process:

[0080] Weigh the raw and auxiliary materials according to the prescription quantity, mix them evenly, add 10% starch slurry to make soft material, pass the soft material through No. Silica gel, mixed well, as slow-release granules.

[0081] Immediate rel...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention discloses a slow-release medicine composition containing Zaltoprofen. The the slow-release medicine composition is compound made of the Zaltoprofen, or the salt and the ester derivative of the Zaltoprofen, the hydrate of the Zaltoprofen or compound made of the Zaltoprofen and other chemical compositions as the effective medicine composition. The invention consists of the effective components, an amount of slow-release material and other excipient acceptable by pharmacy and is made according to scientific design. The slow-release medicine composition has the advantages of mature preparation process, being convenient for industrialization and stable quality. In addition, the slow-release medicine composition can reduce the undesirable reaction of medicine, decrease times of taking medicine and improve the compliance of patients.

Description

Technical field: [0001] The invention relates to a pharmaceutical composition in the technical field of medicine, in particular to a sustained-release pharmaceutical composition containing zaltoprofen and a preparation method and application thereof. Background technique: [0002] Zaltoprofen (Zaltoprofen) is a non-steroidal anti-inflammatory drug with anti-inflammatory, antipyretic and analgesic effects successfully developed by Japanese Chemiphar and Zeria companies. This product selectively acts on the inflammatory site, but has no effect on other organs such as stomach and kidney. Compared with similar drugs such as naproxen and ibuprofen, it has the characteristics of high efficiency and small gastric side effects, so it is well received in clinical practice , its chemical structure is as follows: [0003] [0004] Clinically, it can be used for the treatment of inflammatory or painful diseases such as post-operation, trauma, tooth extraction, chronic rheumatoid art...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/38A61K9/16A61K9/22A61K9/28A61K9/52A61K47/10A61K47/12A61K47/14A61K47/24A61K47/26A61K47/32A61K47/34A61K47/36A61K47/38A61K47/44A61P29/00
Inventor 贾盈
Owner 贾盈
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com