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Polycaprolactone/polyacrylamide graft copolymer and uses thereof

A technology of graft copolymer and alkylacrylamide, which is applied in the field of polyε-caprolactone/polyN-alkylacrylamide graft copolymer, can solve the problems that have not been reported in the research

Inactive Publication Date: 2008-10-15
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] As far as the amphiphilic copolymerization system of polycaprolactone and polyN-alkylacrylamide is concerned at present, the carriers studied are mainly caprolactone and N-alkylacrylamide graft copolymers, while polyN- There is no report on the graft copolymer of alkylacrylamide as hydrophilic side chain and polycaprolactone as hydrophobic backbone

Method used

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  • Polycaprolactone/polyacrylamide graft copolymer and uses thereof
  • Polycaprolactone/polyacrylamide graft copolymer and uses thereof
  • Polycaprolactone/polyacrylamide graft copolymer and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] (1) Preparation of carboxyl-terminated polymer N-isopropylacrylamide (PNIPAAm-COOH):

[0038] N-isopropylacrylamide (200mmol), 3-mercaptopropionic acid (4mmol) and azobisisobutyronitrile (4mmol) were dissolved in 70ml tetrahydrofuran. in N 2 In the atmosphere, react at 70°C for 24h, carboxyl-terminated polymer N-isopropylacrylamide (PNIPAAm-COOH). 1 H-NMR (CDCl 3 , δppm) characteristic peaks: 3.92 (s, H, NCH), 1.19 (s, 6H, CH 3 ). polymer molecular weight 1 The number average molecular weight calculated by H-NMR is: 5680.

[0039]

[0040] (2) Preparation of 4-carbonyl-ε-caprolactone and ε-caprolactone copolymer (PCL-OPD):

[0041] (2-1) Preparation of 4-carbonyl-ε-caprolactone:

[0042] 1,4-cyclohexanedione (0.1 mol) and m-chloroperoxybenzoic acid (0.12 mol) were reacted under reflux at 40° C. for 3 h in 200 ml of dichloromethane. Dichloromethane was distilled off under reduced pressure, and 80 ml of anhydrous diethyl ether was washed twice to obtain a white p...

Embodiment 2～3

[0060] The specific steps and operations of Examples 2 to 3 are basically the same as those in Example 1, except that the molar ratio of the chain transfer reagent 3-mercaptopropionic acid to N-isopropylacrylamide (NIPAAm) is changed to obtain endogenous chains with different molecular weights. carboxyl polymer. The specific data are shown in Table 1 below:

[0061] Table 1

[0062]

Embodiment 4～9

[0064] Embodiment 4~9 concrete steps and operation are basically the same as embodiment 1, and difference is by changing monomer / catalyst charge ratio (M / S n ), reaction time (T), monomer feed ratio (OPD / ε-caprolactone, f OPD ) and other conditions, the polymer composition (OPD / ε-caprolactone, F OPD ), molecular weight (M n ) and changes in molecular weight distribution (PD) and yield. The specific data are shown in Table 2 below:

[0065] Table 2

[0066]

[0067] a When the proportion of OPD units reaches more than 40%, the polymer is no longer soluble in THF, so there is no M for GPC test. n and PD data.

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Abstract

The invention relates to a poly epsilon-CL / poly N-alkyl acrylamide graft multipolymer and an application of the same. The graft multipolymer is a random copolymer copolymerized by 4-carbonyl group-epsilon-CL and epsilon-CL through the random copolymerization and has a molecular weight of between 10,000 and 100,000 as well as is obtained by the reduction reaction and the esterification reaction with the polymer shown by the expression C, wherein, R1, R2 and R3 are respectively selected from one of H or C1-C6 alkyl; moreover, at least one of R2 and R3 is C1-C6 alkyl; the molecule weight of the polymer shown by the expression C is between 1,000 and 20,000; n is between 1 and 6.

Description

technical field [0001] The invention relates to a polycaprolactone / polyacrylamide graft copolymer and its application, in particular to a polyε-caprolactone / poly N-alkylacrylamide graft copolymer and its application. Background technique [0002] Amphiphilic copolymers can quickly and effectively self-assemble in selective solvents to form micro / nano-sized micellar materials, which are widely used in molecular recognition, drug controlled release, gene delivery, nanoreactors and molecular switches and other fields. Amphiphilic polymers can self-assemble in water to form polymer nanoparticles. The hydrophilic and hydrophobic segments of amphiphilic copolymers can be arranged in three ways: random, block and graft. [0003] Due to the simple molecular structure of amphiphilic diblock polymers, it is easy to control the size and stability of nanoparticles, so they have been widely used in the field of drug carriers. In order to enable the delivery and release of guest molecul...

Claims

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Application Information

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IPC IPC(8): C08G81/02C08G63/91C08G63/08C08F120/54C08F8/00A61K47/30
Inventor 郎美东王朝华
Owner EAST CHINA UNIV OF SCI & TECH
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