Effect section of frangrant ainsliaea herb, preparation method and application thereof

A technology of apricot-flavored rabbit ear wind and effective parts, which is applied in the field of effective parts of apricot-flavored rabbit ears and its preparation, and can solve the problems of high cost of drug treatment and insignificant effect

Active Publication Date: 2008-10-29
江西佑美制药有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] As we all know, both hepatitis B and AIDS are diseases that threaten human health and even life. Most of the antiviral drugs currently used are not effective, or some drugs are too expensive to be suitable for the national conditions of our country. This requires us to develop , low-cost antiviral drugs

Method used

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  • Effect section of frangrant ainsliaea herb, preparation method and application thereof
  • Effect section of frangrant ainsliaea herb, preparation method and application thereof
  • Effect section of frangrant ainsliaea herb, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-1

[0027] A method for preparing the effective part of apricot-flavored rabbit ear wind, the preparation method comprises the following steps in sequence:

[0028] Step (1) Take the medicinal material of apricot and rabbit ear wind, add 10% ethanol to carry out percolation or heat reflux extraction, and obtain the extract A;

[0029] Step (2) Take the extract A, concentrate under reduced pressure to obtain the concentrate B;

[0030] Step (3) Take the concentrated solution B, extract it with petroleum ether and ethyl acetate in sequence, combine the extracts, concentrate under reduced pressure, and dry to obtain the effective part of apricot rabbit ear wind;

[0031] Or in step (3) take the concentrated solution B and absorb it on the macroporous adsorption resin, wash it with water until it is colorless or lighter in color, then elute it with 10% ethanol, collect the eluate, concentrate under reduced pressure, and dry to obtain apricot rabbit ear wind effective part.

Embodiment 1-2

[0033] A method for preparing the effective part of apricot-flavored rabbit ear wind, the preparation method comprises the following steps in sequence:

[0034] Step (1) take apricot and rabbit earwind medicinal material, add 80% ethanol to carry out percolation or heat reflux extraction, and obtain the extract A;

[0035] Step (2) Take the extract A, concentrate under reduced pressure to obtain the concentrate B;

[0036] Step (3) Take the concentrated solution B, extract it with petroleum ether and ethyl acetate in sequence, combine the extracts, concentrate under reduced pressure, and dry to obtain the effective part of apricot rabbit ear wind;

[0037] Or step (3) take the concentrated solution B and absorb it with a macroporous adsorption resin, wash it with water until it is colorless or lighter in color, then elute it with 90% ethanol, collect the eluate, concentrate under reduced pressure, and dry to obtain apricot rabbit ear wind effective part.

Embodiment 1-3

[0039] A method for preparing the effective part of apricot-flavored rabbit ear wind, the preparation method comprises the following steps in sequence:

[0040] Step (1) take apricot and rabbit earwind medicinal material, add 50% ethanol to carry out percolation or heat reflux extraction, and obtain the extract A;

[0041] Step (2) Take the extract A, concentrate under reduced pressure to obtain the concentrate B;

[0042] Step (3) Take the concentrated solution B, extract it with petroleum ether and ethyl acetate in sequence, combine the extracts, concentrate under reduced pressure, and dry to obtain the effective part of apricot rabbit ear wind;

[0043] Or in step (3) take the concentrated solution B for adsorption on the macroporous adsorption resin, wash with water until it is colorless or lighter in color, then elute with 60% ethanol, collect the eluate, concentrate under reduced pressure, and dry to obtain apricot rabbit ear wind effective part.

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Abstract

The invention relates to effective part of frangrant ainsliaea herb, a preparation method and application thereof, the invention (1) adopts 10 percent to 80 percent of ethanol to carry out percolation or heating reflux extraction; (2) ethyl acetate is used for extraction or macroporous absorption resin is used for purification. The method adopts water, alcohol, ethyl acetate and other commonly used solvents and has the advantages of simple operation, short process, low cost, high content of active ingredients and so on. The effective part of the frangrant ainsliaea herb mainly contains chlorogenic acid, 3, 5-dicaffeoylquinic acid and other phenolic acid ingredients, has antibacterial and anti-inflammatory effects, has significant inhibition effects on hepatitis B virus, aids virus, human papilloma virus, etc. and has a certain efficacy on cardiovascular diseases; and the effective part of the frangrant ainsliaea herb can be separately used or be matched with other drugs for the development of the new drugs for anti-inflammatory, anti-hepatitis B virus, anti-HIV, anti-human papilloma virus and the treatment of cardiovascular diseases.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to an effective part of apricot-flavored rabbit ear wind and a preparation method thereof. The present invention also relates to the application of the effective parts of the apricot fragrance rabbit ear wind in the development of anti-inflammation, anti-hepatitis B virus, anti-HIV, anti-human papilloma virus, and treatment of cardiovascular diseases. Background technique [0002] Apricot rabbit ear wind is the dry whole plant of Ainslia eamacroclinidioides Hay or Ainslia eafragrans Champ, which has the functions of clearing away heat and detoxification, eliminating phlegm and promoting regeneration, and is currently mainly used in clinical practice. Chronic cervicitis, endometritis, vaginitis, leucorrhea embolism caused by hot and humid betting. Modern research shows that apricot rabbit ear wind mainly contains chlorogenic acid, 3,5-dicaffeoyl quinic acid, 4,5-dicaffeo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28A61P31/12A61P31/04A61P29/00A61P9/00A61P31/20A61P31/18
Inventor 范玫玫杨世林王跃生黄勇简晖饶毅邬秋萍钱霞
Owner 江西佑美制药有限公司
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