Method for preparing adsorbing agent carrier for medical use

Abstract

The invention relates to a method for preparing a medicinal absorbent carrier, comprising the following: a step of preparation of cellulose solution; a step of preparation of crosslinking spherical cellulose particles, which is to add pore-forming agent and crosslinking agent into the cellulose solution for uniform dispersion, to disperse the cellulose solution in dispersant which is added with surface active agent, to increase the temperature to make the crosslinking agent perform crosslinking reaction with the cellulose solution, and then to prepare the crosslinking spherical cellulose particles provided with the pore-forming agent; a step pf aftertreatment, which is to use solvent which can dissolve the pore-forming agent to process the crosslinking spherical cellulose particles, to remove the pore-forming agent, and then to prepare medicinal absorbent carrier-multiaperture crosslinking spherical cellulose particles. The method has the advantages of superior mechanical properties, capability of high pressure resistance, capability of being applied in the blood purification field and so on.

Description

technical field [0001] The invention relates to a preparation method of a medical adsorbent carrier. Background technique [0002] Cellulose can be used as the carrier of medical adsorbents, but due to the limitation of the preparation method, there are three main defects in the traditional cellulose adsorbent carriers: first, they are mostly powdery, fibrous or amorphous particles, and the The hydraulic properties are not good, which will easily cause the bed laminar flow velocity to slow down and the column pressure to increase; the second is that there is no macroporous structure, which causes the solution mass transfer rate to be slow, and it is difficult for macromolecular substances to diffuse into the pores; the third is that the mechanical properties are poor and the strength Low, unable to withstand the requirements of high flow rate and medium and high pressure. After years of research, scientists from all over the world have found a variety of improved methods, b...

AI Technical Summary

Problems solved by technology

[0002] Cellulose can be used as the carrier of medical adsorbents, but due to the limitation of the preparation method, there are three main defects in the traditional cellulose adsorbent carriers: first, they are mostly powdery, fibrous or amorphous particles, and the The hydraulic properties are not good, which will easily cause the bed laminar flow velocity to slow down and the column pressure to increase; the second is that there is no macroporous structure, resulting in slow solution mass transfer, and it is difficult for macromolecular substances to diffuse into the pores; the third is that the mechanical properties are poor and the strength Low, unable to withstand the requirements of high flow rate and medium and high pressure

However, because strong acid and strong alkali are generally used in post-treatment procedures, especially strong alkali can seriously degrade cellulose, and there are other side reactions in the reaction process, so the degree of crosslinking is not ideal.

In addition, when the spherical cellulose particles are prepared, there are already cracks on the outer surface or inside, so the strength of the obtained cellulose particles is not ideal, they cannot withstand the pressure of a higher flow rate, and they are easily broken to form particles, which can only be used for proteins, polysaccharides, etc. The separation and purification process of biological macromolecules cannot be used in the field of blood purification