Diaryl substituted pyrazole derivative, preparation method and application thereof

A methyl and alkyl technology, applied in the field of novel diaryl substituted pyrazole derivatives, can solve the problems of unsatisfactory affinity and low CB1 receptor selectivity
CN101318931AInactive Publication Date: 2008-12-10SHANGHAI SUN SAIL PHARMA SCI & TECH CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANGHAI SUN SAIL PHARMA SCI & TECH CO LTD
Publication Date
2008-12-10
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a novel antagonist and / or an inverse agonist of cannabinoide receptor-1 (cannabinoid receptor type 1, CB1) with a structural formula shown as a formula (I), a preparation method and an application thereof. In the structural formula, R1, R2, R3, R4, R5, R6, R7 and R8 are defined as the specification sheet. The compound of the invention can be used for treating, preventing or relieving diseases mediated by the CB1 receptor. The compound and pharmaceutically acceptable salt thereof can also be used for treating, preventing or relieving adiposity, diabetes mellitus, drug dependence, cognitive defect, nervous system diseases, diseases of gastrointestinal tract and cirrhosis.
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Description

technical field

[0001] The present invention relates to a novel diaryl-substituted pyrazole derivative, its preparation method and use. This type of compound can be used as a powerful cannabinoid receptor-1 (Cannabinoid receptor type 1, CB1) receptor antagonist and / or inverse agonist and has high selectivity to CB1, the compound of the present invention and its pharmacologically acceptable Salts of CB1 can be used to treat, prevent or alleviate diseases mediated by CB1 receptors, such as obesity, diabetes, drug dependence, cognitive deficits, nervous system diseases, gastrointestinal diseases, and liver cirrhosis. Background technique

[0002] Obesity is a complex metabolic disease caused by multiple factors and has become a global health problem. Obesity occurs when the energy intake of the human body is greater than the energy consumed by the human body, which has extremely adverse effects on human health and maintaining a good physical and mental state. According to the...

Claims

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