Preparation method of sustained and controlled release medicine material

A controlled-release material and drug technology, applied in drug combinations, pharmaceutical formulations, chemical instruments and methods, etc., can solve the problems of inability to maintain the blood drug concentration in the target area for a long time, the inability to deliver the drug to the target area, and side effects, etc., to achieve No physiological activity, biocompatibility, short cycle, and simple steps

Inactive Publication Date: 2009-01-07
BEIJING UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Several major problems in drug treatment include: (1) the drug cannot be delivered to the target area accurately; (2) the effective blood drug concentration in the target area cannot be maintained for a long time; (3) the blood drug concentration in the non-target area is relatively low. High, there is a risk of side effects

Method used

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  • Preparation method of sustained and controlled release medicine material
  • Preparation method of sustained and controlled release medicine material
  • Preparation method of sustained and controlled release medicine material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Synthesis experiment: Dissolve 2.61g of cetyltrimethylammonium bromide in 104g of distilled water, stir until dissolved, pipette 8ml of tetraethyl orthosilicate into the solution, add fresh ammonia water, adjust the pH to 9, and maintain the stirring rate 500pm / min until a white blocky gel is produced, suction filtered, washed, filtered, and the resulting white powder is dried. After drying, the product is heated to 550°C and baked for 6 hours to obtain a 3nm primary pore structure and a 20nm secondary pore structure. Dual-model mesoporous molecular sieve;

[0038] Molecular sieve functionalization: Add 0.002 mol of triaminotriethoxysilane to 100 ml of absolute ethanol to make the concentration of triaminotriethoxysilane 0.02 mol / L to obtain solution A1. The dual-model mesoporous molecular sieves were vacuum activated at 150 °C for 5 hours. Take 1 g of the activated dual-model mesoporous molecular sieve and add it to solution A1, stir at room temperature for 5 hours, t...

Embodiment 2

[0043] Synthesis experiment: Dissolve 2.61g of cetyltrimethylammonium bromide in 104g of distilled water, stir until dissolved, pipette 8ml of tetraethyl orthosilicate into the solution, add fresh ammonia water, adjust the pH to 9, and maintain the stirring rate 500pm / min until a white blocky gel is produced, suction filtered, washed, filtered, and the resulting white powder is dried. After drying, the product is heated to 550°C and baked for 6 hours to obtain a 3nm primary pore structure and a 20nm secondary pore structure. Dual-model mesoporous molecular sieve;

[0044] Molecular sieve functionalization: 0.005 mol of triaminotriethoxysilane was added to 100 ml of methanol so that the concentration of triaminotriethoxysilane was 0.05 mol / L to obtain solution A1. The dual-model mesoporous molecular sieves were vacuum activated at 150 °C for 5 hours. Take 1 g of the activated dual-model mesoporous molecular sieve and add it to solution A1, stir at room temperature for 5 hours,...

Embodiment 3

[0048] Synthesis experiment: Dissolve 2.61g of cetyltrimethylammonium bromide in 104g of distilled water, stir until dissolved, pipette 8ml of tetraethyl orthosilicate into the solution, add fresh ammonia water, adjust the pH to 9, and maintain the stirring rate 500pm / min until a white blocky gel is produced, suction filtered, washed, filtered, and the resulting white powder is dried. After drying, the product is heated to 550°C and baked for 6 hours to obtain a 3nm primary pore structure and a 20nm secondary pore structure. Dual-model mesoporous molecular sieve;

[0049] Molecular sieve functionalization: Add 0.01 mol of triaminotriethoxysilane to 100 ml of absolute ethanol to make the concentration of triaminotriethoxysilane 0.1 mol / L to obtain solution A1. The dual-model mesoporous molecular sieves were vacuum activated at 150 °C for 5 hours. Take 1 g of the activated dual-model mesoporous molecular sieve and add it to solution A1, stir at room temperature for 5 hours, the...

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Abstract

The invention relates to a method for preparing the medical sustained and controlled release material, which belongs to the field of the mesoporous molecular sieve. The preparation method comprises the following steps: preparing pure silicon-based double-model mesoporous molecular sieve with double-pore structure and controllable pore canal size; dissolving silane coupler in the organic solvent, and obtaining solution A by adjusting the concentration of the silane coupler; activating the double-model mesoporous molecular sieve for 5 hours in the vacuum at 150 DEG C, then adding the molecular sieve to the solution A by a certain proportion, mixing the molecular sieve and the solution A for 5 hours at the room temperature, filtering and washing, drying the solid obtained from filtering, and then obtaining the functionalized double-model mesoporous molecular sieve; adding the medicine to the organic solvent, and obtaining solution B by adjusting the concentration of the medicine; adding the functionalized molecular sieve into the solution B according to certain proportion, mixing the molecular sieve with the solution B for 8 to 12 hours at the room temperature, filtering and washing, drying the solid obtained from washing at 60-80 DEG C, and obtaining solid powder. The preparation method has the advantages of stable structure, physiological non-toxicity, high medicine load, long medicine release time and stable medicine release rate.

Description

technical field [0001] The invention relates to a preparation method of a drug sustained and controlled release material, in particular to the preparation of a functionalized pure silicon-based dual-model mesoporous molecular sieve with a dual-pore structure and controllable channel size according to the chemical and physical properties of the drug. technical background [0002] Several major problems in drug treatment include: (1) the drug cannot be delivered to the target area accurately; (2) the effective blood drug concentration in the target area cannot be maintained for a long time; (3) the blood drug concentration in the non-target area is relatively low. High, there is a hidden danger of side effects. In order to solve this problem, sustained-release and controlled-release agents have emerged. In recent years, research on sustained-release and controlled-release preparations has developed rapidly. In 1999, the global sales of such products were close to 10 billion ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/02C01B39/00A61K31/192A61K31/616A61P29/00
Inventor 孙继红高琳
Owner BEIJING UNIV OF TECH
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