Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Dextran in situ forming eye gel

A dextran and gel technology, which is applied in the field of dextran ophthalmic ready-to-use gels, can solve the problems of large loss of eye drops, short retention time, and limit the wide use of the curative effect of dextran eye drops, so as to prolong the retention time, improve the curative effect, Enriching the effect of pharmaceutical dosage forms

Inactive Publication Date: 2009-01-21
肖正连
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Dextran eye drops is a commonly used ophthalmic preparation, but clinically there is a large loss of eye drops instilled into the eye and a short residence time. These problems limit the curative effect and wider use of dextran eye drops

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Dextran in situ forming eye gel
  • Dextran in situ forming eye gel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Prescription: 1 gram of dextran, 400 ml of hydrochloric acid (0.05mol / L)

[0025] Sodium Citrate 8.7g Methylcellulose 5.0g Phenylethyl Alcohol 0.5g

[0026] Ethanol 5ml Sodium Chloride 1.0g PEG-1000 20g

[0027] PEG-400 5g water for injection appropriate amount

[0028] Preparation method: Heat water for injection to boil, cool to 80°C, add dextran, dissolve phenylethyl alcohol in ethanol, add dropwise to the above solution while stirring, add sodium citrate, stir for more than 30 minutes, then add hydrochloric acid and stir, Filter through a microporous membrane (0.22 μm), heat the filtrate to 40°C, add sodium chloride, methylcellulose, PEG-1000 and PEG-400 while it is hot, stir to room temperature (18-25°C), and then Add water for injection to make up the weight to 1000 ml, stir to make it form a uniform gel, and aseptically pack it.

Embodiment 2

[0030] Prescription: 1.2 grams of dextran, 200 milliliters of sulfuric acid (0.05mol / L)

[0031] Sodium Citrate 8.7g Methylcellulose 5.0g Benzyl Alcohol 0.5g

[0032] Ethanol 5ml Sodium Chloride 2.0g PEG-1000 70g

[0033] Appropriate amount of water for injection

[0034] Preparation method: heat water for injection to boil, cool to 80°C, add dextran, dissolve benzyl alcohol in ethanol, add dropwise to the above solution while stirring, add sodium citrate, stir for more than 30 minutes, then add sulfuric acid and stir, Filter through a microporous membrane (0.22μm), heat the filtrate to 40°C, add sodium chloride, methylcellulose and PEG-1000 while hot, stir to room temperature (18-25°C), add water for injection to make up The weight is up to 1000 milliliters, stirred to form a uniform gel, and aseptically packed.

Embodiment 3

[0036] Prescription: Dextran 1.3g Sodium Hydroxide (0.1mol / L) 200ml

[0037] Boric acid 5.6g Methylcellulose 5.0g Sodium benzoate 0.5g

[0038] Ethanol 5ml Sodium Chloride 5.0g PEG-4000 100g

[0039] Appropriate amount of water for injection

[0040] Preparation method: heat and boil water for injection, cool to 80°C, add dextran, sodium citrate, sodium hydroxide and sodium benzoate, stir for more than 30 minutes, then add boric acid and stir, pass through a microporous membrane (0.22μm) Filtrate, heat the filtrate to 40°C, add PEG-4000 and methylcellulose while hot, stir to room temperature (18-25°C), add water for injection to make up the weight to 1000 ml, stir to form a uniform gel , aseptically packaged.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a dextran forming gel for eye use and a preparation method thereof. 1,000ml dextran forming gel for eye use of the invention contains 0.5 to 1.5g of dextran, 0.05 to 1g of antiseptic, 1.0 to 7.5g of osmoregulator, 30 to 150g of gel matrix and the rest of acid-base buffering agent and injection water. The invention, with the optimization of auxiliary materials and the improvement of process, enriches the dosage forms of dextran, greatly extends the staying time in eyes of the medicine and improves the curing effect without adverse stimulus responses.

Description

【Technical field】 [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a dextran ophthalmic instant gel. 【Background technique】 [0002] Ophthalmic instant gel is also called ophthalmic in-situ gel or ophthalmic in-situ gel. Its preparation is liquid when placed at room temperature. Gel-like, it can stay in the eye for a long time, so as to prolong the treatment time, enhance the treatment effect and reduce the loss of medicine. [0003] Instant ophthalmic gel is not yet a very mature pharmaceutical preparation, and instant ophthalmic gel, which depends on the principles of temperature, pH value and ionic strength, is not yet mature in commercialization, because the dosage form is not only It requires fine technology, appropriate excipients, and the proper matching of drugs, processes and excipients in ophthalmic ready-to-use gels. Otherwise, it cannot be placed in a liquid state at room temperature, and it will b...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/721A61K9/00A61K47/32A61K47/34A61K47/38A61P27/02A61K47/10
Inventor 肖正连
Owner 肖正连
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com