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Multichannel surface plasma wave sensing detection system

A surface plasmon wave and detection system technology, applied in the field of biosensors, can solve the problems of high false positive rate, complicated operation, poor specificity, etc., achieve high detection sensitivity, simplify the detection process, and ensure consistency

Inactive Publication Date: 2009-01-21
THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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  • Abstract
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Problems solved by technology

[0005] In view of this, the purpose of the present invention is to provide a multi-channel surface plasmon wave sensing and detection system, which can overcome the complex operation and false positive rate existing in the prior art High and low throughput, poor specificity and other shortcomings, and various detection items, less time-consuming, high sensitivity, easy to carry, especially can fully meet the needs of use in complex environments, and has broad application prospects

Method used

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  • Multichannel surface plasma wave sensing detection system
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  • Multichannel surface plasma wave sensing detection system

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Embodiment Construction

[0033]1-reaction cell; 2-lens I; 3-substrate; 4-metal film; 5-biological probe placement point; 6-polarized light source; 7-control system; 8-converging lens; 9-photodetector; Signal amplification circuit; 11-A / D conversion circuit, 12-signal analysis / processing circuit; 13-display circuit; 14-light transmitter; 15-lens II; 16-filter; 17-polarizer; 18-column surface lens; 19-temperature control device; 20-sample liquid inlet; 21-sample liquid outlet; 22-intelligent analysis platform; 23-stepping motor; 24-subdivision driving device; 25-stepping motor controller.

[0034] figure 1 It is a structural schematic diagram of the present invention; figure 2 Schematic diagram for the coating of biological probes; image 3 It is a schematic diagram of photoelectric signal transmission; Figure 4 It is a schematic diagram of the control structure of the cruising adjustable light source. As shown in the figure, the present invention includes an SPR biosensing detection device, an in...

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Abstract

The invention discloses a multi-channel surface plasma wave sensing-monitoring system, which comprises a SPR biological sensing-monitoring device, an incident light channel, an exit light channel and an intelligent analysis processing platform, wherein the SPR biological sensing-monitoring device comprises a SPR biological sensor and an adjustable detecting light source, the incident light channel comprises a cruising adjustable polarized light source which comprises a polarized light source and a control system, and the exit light channel comprises a convergent lens and a photodetector. The multi-channel surface plasma wave sensing-monitoring system can accurately analyze the interaction (the function of multiple factors) of various matters in specimens, avoids system deviation which is brought by single measurement, greatly reduces monitoring time, and improves monitoring efficiency. The invention has the advantages of compact structure, convenient carrying, convenient employment and high sensitiveness, which can be applied in a plurality of fields and various environments, and has wide application prospect.

Description

technical field [0001] The invention relates to the field of biosensors, in particular to a multi-channel surface plasmon wave sensing and detection system. Background technique [0002] Surface plasmon resonance (SPR) is a physical optics phenomenon. Surface plasmon resonance detection is a detection technology using surface plasmon waves (SPW, Surface Plasma Wave), which has the advantages of no labeling, high speed, specificity, high sensitivity, and a large number of parallel screening. Surface plasmons (SP) are formed by electromagnetic waves propagating along the interface between a metal and a dielectric. When the polarized light parallel to the surface is incident on the interface at an angle called surface plasmon resonance, when attenuated total reflection occurs, the incident light is coupled into the surface plasmon, and a large amount of light energy is absorbed. At this angle, due to the surface plasmon resonance Causes a significant reduction in reflected li...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/55G01N21/41G01N21/552
Inventor 王珏罗阳府伟灵
Owner THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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