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Medicament for treating encephalitis b and preparation method thereof

A type of Japanese encephalitis and ethanol technology, which is applied in drug delivery, pharmaceutical formulations, and resistance to media-borne diseases, etc., can solve the difficulty of universal vaccination, and the Japanese encephalitis human immunoglobulin has not been seen to treat Japanese encephalitis, and it cannot be effectively treated JE drugs and other issues, to achieve the effect of good quality, high yield and purity, and high virus safety

Active Publication Date: 2011-06-08
SICHUAN YUANDASHUYANG PHARM CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preventive effect of live attenuated Japanese encephalitis vaccine is good, but it is difficult to vaccinate the whole population. Therefore, effective therapeutic drugs after the onset of Japanese encephalitis have become the focus of research in this field
[0003] At present, there is no relevant report on the drug that can effectively treat JE, let alone the relevant report on the use of JE human immunoglobulin in the treatment of JE

Method used

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  • Medicament for treating encephalitis b and preparation method thereof

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Comparison scheme
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Embodiment 1

[0056] The preparation of embodiment 1 Japanese encephalitis human immunoglobulin intravenous injection

[0057] 1. Before production, each bag of plasma should be re-examined for infectious pathogenic microbial markers such as hepatitis B surface antigen (HBsAg), HCV antibody, HIV (1+2) antibody, syphilis, and ALT with diagnostic reagents approved by the state. The results should be is negative. Eliminate unqualified plasma and strictly prevent cross-contamination between unqualified plasma bags and normal plasma during the melting operation.

[0058] 2. Disinfect the surface of the plasma bag, break the bag, melt the plasma temperature to 0-4°C, and separate the components according to the low-temperature ethanol protein separation method:

[0059] Dilute the plasma protein content with 9g / L sodium chloride solution to 45-55g / L, adjust the pH value to 7.0±0.4, add 95% ethanol until the ethanol concentration of the reaction solution is 8%. The temperature of the reaction so...

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Abstract

The invention relates to a drug used for treating Japanese encephalitis and a preparation method thereof, belonging to the field of blood products. The invention provides a drug which can effectively treat Japanese encephalitis, thus solving the technical problem. The drug for treating Japanese encephalitis of the invention is a preparation prepared by taking Japanese encephalitis human immunoglobulin as an active ingredient and adding medicinally acceptable accessories. The drug can effectively cure Japanese encephalitis and provides a novel drug choice for Japanese encephalitis patients. Inaddition, the Japanese encephalitis human immunoglobulin intravenous injection prepared by the method of the invention has the advantages of better quality, high yield and purification, high virus safety and great application prospect.

Description

technical field [0001] The invention relates to a medicine for treating Japanese encephalitis and a preparation method thereof, belonging to the field of blood products. Background technique [0002] Epidemic encephalitis B (Epidemic encephalitis B) is referred to as Japanese encephalitis, an acute insect-borne infectious disease with high mortality and disability rates. . Vector control is poor, and the disease is clinically characterized by high fever, disturbance of consciousness, convulsions, and meningeal irritation. In severe patients with central respiratory failure, the mortality rate is as high as 20-50%. After the disease, there may be disturbance of consciousness, dementia, aphasia, paralysis, epilepsy and other neuropsychiatric and mental disabilities, and the incidence rate is 45%. The preventive effect of live attenuated JE vaccine is good, but it is difficult to vaccinate the whole population. Therefore, effective therapeutic drugs after the onset of JE have...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K39/42A61K9/00A61K9/19A61P31/14C07K16/06
CPCY02A50/30
Inventor 魏宪义
Owner SICHUAN YUANDASHUYANG PHARM CO LTD