Use of ilexlutifolia thumb total glycosides and preparation method thereof

A technology of Kudingcha total glycosides and Kudingcha, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, plant raw materials, etc., can solve problems such as organic solvent residues, rising production costs, and affecting separation effects, and achieve production The effect of process safety, cost saving and cost reduction

Inactive Publication Date: 2009-02-11
贺震旦
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The degreasing link will bring many problems in large-scale production: 1) organic solvent residue; 2) petroleum ether is a flammable liquid, which will bring serious safety problems; 3) increase production costs; 4) prolong production time, etc.; But if the fat is not removed, it will seriously affect the separation effect

Method used

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  • Use of ilexlutifolia thumb total glycosides and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1 The effect of total glucosides of Kudingcha on the levels of MDA, GSH and TG in the alcoholic liver of Kunming mice induced by ethanol

[0028] Test sample: the sample is Kudingcha total glycosides.

[0029] Dosage: There are three dosage groups of 0.22, 0.44, and 1.32g / kg BW, which are 5, 10, and 30 times the recommended daily dose for the human body. A blank control group and an ethanol control group are also set up. The doses are: 1) blank control group 0.00g / kg BW; 2) ethanol control group 0.00g / kg BW; 3) low dose group 0.22g / kg BW; 4) medium dose group 0.44g / kg BW; 5) High dose group 1.32g / kg BW.

[0030] Preparation of test substance: Dilute 2.64g of test sample to 40.0ml with purified water every day to prepare the test substance of the high-dose group, then dilute 5.0 and 10.0ml of the test substance of the high-dose group to 30.0ml with purified water respectively. Low and middle dose groups of test substances.

[0031] The route of administration ...

Embodiment 2

[0036] Example 2 Effect of total glucosides of Kudingcha on the levels of ALT and AST in fatty liver of Kunming mice induced by carbon tetrachloride

[0037] Test sample: the sample is Kudingcha total glycosides.

[0038] Dosage: There are three dosage groups of 0.22, 0.44, and 1.32g / kg BW, which are 5, 10, and 30 times the recommended daily dose for the human body. A blank control group and an ethanol control group are also set up. The doses are: 1) blank control group 0.00g / kg BW; 2) ethanol control group 0.00g / kg BW; 3) low dose group 0.22g / kg BW; 4) medium dose group 0.44g / kg BW; 5) High dose group 1.32g / kg BW.

[0039] Preparation of test substance: Dilute 2.64g of test sample to 40.0ml with purified water every day to prepare the test substance of the high-dose group, then dilute 5.0 and 10.0ml of the test substance of the high-dose group to 30.0ml with purified water respectively. Low and middle dose groups of test substances.

[0040] The way of giving the test subs...

Embodiment 3

[0046] Embodiment 3 The preparation method of Kudingcha total glycosides of the present invention comprises the following steps:

[0047] A, weigh and pulverize the purchased Kudingcha that meets the quality standard requirements, and pass through a 20-mesh sieve to obtain raw materials;

[0048] B. Use 5 times the amount of 80% edible alcohol to reflux extract twice at 60°C, the first extraction time is 2 hours, the second extraction time is 1.5 hours, and the two extractions are combined;

[0049] C. Filter the above extract, concentrate under reduced pressure, control the concentration temperature to be 60°C, and the concentration pressure is -0.085mPa, and concentrate to ethanol extract with a relative density of 1.1 to 1.2;

[0050] D, the obtained concentrated extract, add 5 times the amount of pure water and fully stir for 15 minutes, after standing for 45 minutes, pour out the supernatant night, do this twice, combine the two aqueous solutions, and carry out centrifuga...

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Abstract

The invention relates to an application of broadleaf holly leaf glycosides and a preparation method thereof. Researches show that the broadleaf holly leaf glycosides can lower level of malondialdehyde (MDA) and triglyceride (TG) in liver tissues, increase level of reduced glutathione(GSH) of each dosage group in liver tissues, lower level of Alanine Aminotransferase (ALT) and Aspertate Aminotransferase (AST) in liver tissues; the broadleaf holly leaf glycosides has the activity of anti-alcoholic hepatitis and anti-adiposis hepatica. Compared with the prior art, the invention has the advantages of: 1. providing a new application of broadleaf holly leaf glycosides, in particular to an application on preparing medicines for curing adiposis hepatica and alcoholic hepatitis; 2. providing a preparation method for broadleaf holly leaf glycosides, and the preparation method is safe in production technics, economic in cost, high in efficacy, easy for quality control and more simple in preparation; and 3. providing a preparation of broadleaf holly leaf glycosides.

Description

【Technical field】 [0001] The invention relates to total glycosides of kudingcha, in particular to its new application in pharmacy and its preparation method, which belongs to the field of pharmacy. 【Background technique】 [0002] Kudingcha is a unique resource species in China. So far, it has been drunk as a folk traditional tea for more than 2,000 years, and it is a unique and large resource species in my country. As listed in the table, the original plant of Kudingcha belongs to 5 families, 5 genera and 10 species [Yunnan Botanical Research 1992; 14(3): 328 336]. [0003] The original plant of Kudingcha in various parts of my country [0004] Chinese name Latin scientific name Branch name 1 privet Ligustrum pedunculare Rehd. Oleaceae 2 Amethyst privet L. purpurascens Y.C. Yang Oleaceae 3 japanese hairy privet L. japonicum Thunb var. pubescens Koidz. Oleaceae 4 thick privet L. robustum (Roxb.) B1. Oleaceae ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61K9/08A61K9/10A61K9/16A61K9/20A61K9/48A61P1/16
Inventor 贺震旦
Owner 贺震旦
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